Tolerability of Selective Serotonin Reuptake Inhibitors

The Serotonin Syndrome

2005 • 1,720 citations

Adverse Drug Events in Ambulatory Care

2003 • 1,343 citations

CYP2D6 Genotype, Antidepressant Use, and Tamoxifen Metabolism During Adjuvant Breast Cancer Treatment

2005 • 910 citations

Central Nervous System–Active Medications and Risk for Falls in Older Women

2002 • 614 citations

Rhabdomyolysis

2005 • 587 citations

Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs

2002 • 551 citations

Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials

2005 • 505 citations

Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine

2001 • 485 citations

Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study

1999 • 445 citations

CYP2D6 and CYP2C19 genotype‐based dose recommendations for antidepressants: a first step towards subpopulation‐specific dosages

2001 • 429 citations

Relative Toxicity of Selective Serotonin Reuptake Inhibitors (SSRIs) in Overdose

2004 • 418 citations

Allelic Variation in the Serotonin Transporter Promoter Affects Onset of Paroxetine Treatment Response in Late-Life Depression

2000 • 410 citations

Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people

1998 • 382 citations

Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture

2007 • 380 citations

Use of Selective Serotonin Reuptake Inhibitors and Risk of Upper Gastrointestinal Tract Bleeding

2003 • 378 citations

Movement Disorders Associated With the Serotonin Selective Reuptake Inhibitors

1996 • 360 citations

Discontinuation of Use and Switching of Antidepressants

2002 • 357 citations

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1997 • 357 citations

Suicide prevention — a medical breakthrough?

2000 • 351 citations

Comparison of Citalopram, Perphenazine, and Placebo for the Acute Treatment of Psychosis and Behavioral Disturbances in Hospitalized, Demented Patients

2002 • 330 citations

Association between antidepressant prescribing and suicide in Australia, 1991-2000: trend analysis

2003 • 326 citations

Selective Serotonin Reuptake Inhibitors and Myocardial Infarction

2001 • 307 citations

Pharmacogenetics of Antidepressant Medication Intolerance

2003 • 284 citations

Antidepressants for depressed elderly

2006 • 282 citations

Effects of the Serotonin Transporter Gene Promoter Polymorphism onMirtazapine and Paroxetine Efficacy and Adverse Events in Geriatric MajorDepression

2004 • 275 citations

Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort

2001 • 265 citations

Effect of Antidepressants and Their Relative Affinity for the Serotonin Transporter on the Risk of Myocardial Infarction

2003 • 246 citations

Hyponatremia Associated with Selective Serotonin-Reuptake Inhibitors in Older Adults

2006 • 243 citations

A Review of Serotonin Toxicity Data: Implications for the Mechanisms of Antidepressant Drug Action

2006 • 239 citations

Depression Treatment in a Sample of 1,801 Depressed Older Adults in Primary Care

2003 • 231 citations

The Clinical Pharmacokinetics of Escitalopram

2007 • 227 citations

Adverse Reactions of Selective Serotonin Reuptake Inhibitors

1999 • 219 citations

Incidence and Duration of Side Effects and Those Rated as Bothersome With Selective Serotonin Reuptake Inhibitor Treatment for Depression

2004 • 218 citations

Paroxetine decreases platelet serotonin storage and platelet function in human beings

2000 • 216 citations

Cyp2d6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants—a pilot study

2004 • 198 citations

Exposure to Tricyclic and Selective Serotonin Reuptake Inhibitor Antidepressants and the Risk of Hip Fracture

2003 • 194 citations

Antidepressant studies in Parkinson's disease: A review and meta‐analysis

2005 • 190 citations

Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment

2003 • 181 citations

Expanding the Black Box — Depression, Antidepressants, and the Risk of Suicide

2007 • 169 citations

Hyponatraemia and selective serotonin re‐uptake inhibitors in elderly patients

2001 • 162 citations

The role of psychological factors in alopecia areata and the impact of the disease on the quality of life

2004 • 155 citations

The Risk of Suicide With Selective Serotonin Reuptake Inhibitors in the Elderly

2006 • 153 citations

Antidepressant-Associated Mania and Psychosis Resulting in Psychiatric Admissions

2001 • 150 citations

General population based study of the impact of tricyclic and selective serotonin reuptake inhibitor antidepressants on the risk of acute myocardial infarction

2005 • 147 citations

The Evolution of Drug Metabolism

2000 • 146 citations

Hyponatraemia in elderly psychiatric patients treated with Selective Serotonin Reuptake Inhibitors and venlafaxine: a retrospective controlled study in an inpatient unit

2002 • 144 citations

Use of antidepressants and risk of colorectal cancer: a nested case-control study

2006 • 131 citations

Falls among frail older people in residential care

2002 • 128 citations

Does Fluoxetine Have Any Effect on the Cognition of Patients With Mild Cognitive Impairment?

2007 • 127 citations

Antidepressant Medication Use and Breast Cancer Risk

2000 • 126 citations

Severe Adverse Drug Reactions of Antidepressants: Results of the German Multicenter Drug Surveillance Program AMSP

2004 • 126 citations

Paroxetine in Parkinson’s disease: Effects on motor and depressive symptoms

2000 • 126 citations

Paroxetine and Fluoxetine Effects On Mood and Cognitive Functions in Depressed Nondemented Elderly Patients

2002 • 120 citations

SSRIs Do Not Worsen Parkinson's Disease: Evidence from an Open-Label, Prospective Study

2001 • 117 citations

Tolerability of paroxetine in Parkinson's disease: A prospective study

2000 • 111 citations

Efficacy and Tolerability of Citalopram in the Treatment of Late-Life Anxiety Disorders: Results From an 8-Week Randomized, Placebo-Controlled Trial

2004 • 110 citations

Clinical effects of pharmacological variations in selective serotonin reuptake inhibitors: an overview

2005 • 109 citations

Effect of Depression on Stroke Morbidity and Mortality

2003 • 106 citations

Pharmacological Differences of Serotonin Reuptake Inhibitors and Possible Clinical Relevance

1992 • 105 citations

A comparison of side effects of selective serotonin reuptake inhibitors and tricyclic antidepressants in older depressed patients: a meta‐analysis

2004 • 104 citations

Serum Levels and Cardiovascular Effects of Tricyclic Antidepressants and Selective Serotonin Reuptake Inhibitors in Depressed Patients

2001 • 100 citations

Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective -demethylation and reduces the hypoalgesic effect of tramadol

2005 • 100 citations

Use of selective serotonin reuptake inhibitors and risk of developing first‐time acute myocardial infarction

2001 • 99 citations

Pharmacogenomics and antidepressant drugs

2006 • 99 citations

Does fluoxetine exacerbate Parkinson's disease?

1992 • 97 citations

Increased use of selective serotonin reuptake inhibitors in patients admitted with gastrointestinal haemorrhage: a multicentre retrospective analysis

2006 • 96 citations

Withdrawal reactions with selective serotonin re-uptake inhibitors as reported to the WHO system

1997 • 96 citations

A Randomized, Controlled Trial of the Effectiveness of Cognitive–Behavioral Therapy and Sertraline versus a Waitlist Control Group for Anxiety Disorders in Older Adults

2006 • 95 citations

Pharmacological treatment for unipolar psychotic depression

2006 • 94 citations

Comparison of the tolerability and efficacy of citalopram and?amitriptyline in elderly depressed patients treated in general practice

1998 • 93 citations

Drugs and falls in older people in geriatric care settings

2004 • 91 citations

Current Use of Selective Serotonin Reuptake Inhibitors and Risk of Acute Myocardial Infarction

2004 • 89 citations

Does concurrent prescription of selective serotonin reuptake inhibitors and non‐steroidal anti‐inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding?

2005 • 87 citations

Antidepressant drug use in primary care: a record linkage study in Tayside, Scotland

1996 • 84 citations

Risk Factors for Extrapyramidal Symptoms During Treatment With Selective Serotonin Reuptake Inhibitors, Including Cytochrome P-450 Enzyme, and Serotonin and Dopamine Transporter and Receptor Polymorphisms

2006 • 84 citations

Risk of Breast Cancer According to Use of Antidepressants, Phenothizaines, and Anthistamines

1999 • 81 citations

Selective serotonin reuptake inhibitor‐induced urinary incontinence

2002 • 81 citations

Bleeding and Selective Serotonin Reuptake Inhibitors in Childhood and Adolescence

2000 • 81 citations

Persistence, Switching, and Discontinuation Rates Among Patients Receiving Sertraline, Paroxetine, and Citalopram

2005 • 80 citations

Selective serotonin-reuptake inhibitor antidepressants increase the risk of falls and hip fractures in elderly people by inhibiting cardiovascular ion channels

2001 • 80 citations

Hair loss in psychopharmacology.

2000 • 79 citations

Adverse events and treatment discontinuations in clinical trials of fluoxetine in major depressive disorder: An updated meta-analysis

2000 • 77 citations

Cerebrovascular Effects of Selective Serotonin Reuptake Inhibitors

2004 • 77 citations

Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin

2003 • 76 citations

Drug Interactions of Clinical Significance with Selective Serotonin Reuptake Inhibitors

1997 • 76 citations

Extrapyramidal syndromes associated with selective serotonin reuptake inhibitors: a case???control study using spontaneous reports

2002 • 74 citations

Prognosis of Patients Taking Selective Serotonin Reuptake Inhibitors Before Coronary Artery Bypass Grafting

2006 • 74 citations

Fluoxetine in Elderly Patients: Is There Cause for Concern?

1992 • 72 citations

Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding?

2001 • 70 citations

Outpatient Medications and Hip Fractures in the US

2005 • 70 citations

Antidepressants and risk of first-time hospitalization for myocardial infarction: A population-based case-control study

2004 • 69 citations

Late-Life Depression: A Model for Medical Classification

2005 • 69 citations

Discontinuation symptoms in users of selective serotonin reuptake inhibitors in clinical practice: tapering versus abrupt discontinuation

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Postprandial Systolic Blood Pressure Responses of Older People in Residential Care: Association with Risk of Falling

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Recent Advances in Geriatric Psychopharmacology

1995 • 63 citations

Risk of syncope in the elderly and consumption of drugs: A case-control study

1997 • 63 citations

Paroxetine: population pharmacokinetic analysis in late‐life depression using sparse concentration sampling

2006 • 61 citations

Retrospective Review of Selective Serotonin Reuptake Inhibitors and Falling in Older Nursing Home Residents

2001 • 60 citations

Suicide and self‐harm following prescription of SSRIs and other antidepressants: confounding by indication

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Cisapride for the treatment of nausea produced by selective serotonin reuptake inhibitors

1994 • 57 citations

Antidepressants, Warfarin, and the Risk of Hemorrhage

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Antidepressant use and the risk of breast cancer

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Delayed Recurrent SIADH Associated with SSRIs

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A randomized, placebo-controlled trial of paroxetine in nursing home residents with non-major depression

2002 • 52 citations

Antidepressant medication use and breast cancer risk: a case-control study

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Systematic Overview of Drug Interactions with Antidepressant Medications

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No evidence of increased adverse drug reactions in cytochrome P450 CYP2D6 poor metabolizers treated with fluoxetine or nortriptyline

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Serotonergic innervation of the cerebral vasculature: relevance to migraine and ischaemia

1991 • 50 citations

Newer antidepressants: evaluation of fatal toxicity index and interaction with alcohol based on Finnish postmortem data

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Differential effectiveness of newer and older antidepressants appears mediated by an age effect on the phenotypic expression of depression

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Start of a selective serotonin reuptake inhibitor (SSRI) and increase of antiparkinsonian drug treatment in patients on levodopa

2002 • 48 citations

Nocturia, depression and antidepressant medication

2005 • 48 citations

Weight Outcomes Among Antidepressant Users in Nursing Facilities

2001 • 47 citations

Antidepressant use and breast cancer risk

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Serotonergic Antidepressants and Urinary Incontinence

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Selective serotonin reuptake inhibitors and hyponatraemia: review and proposed mechanisms in the elderly

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The Antidepressant Effects of 5-HT Uptake Inhibitors

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Does increasing dose improve efficacyin patients with poor antidepressantresponse: a review

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A double‐blind comparison of citalopram (Lu 10–171) and amitriptyline in depressed patients

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Escitalopram in clinical practice: Results of an open-label trial in a naturalistic setting

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Use of Selective Serotonin Reuptake Inhibitors and Sleep Disturbances in Community‐Dwelling Older Women

2006 • 32 citations

Paroxetine and Galactorrhea

1997 • 31 citations

Cytochrome P450 2D6 genotype does not predict SSRI (fluoxetine or paroxetine) induced hyponatraemia

2002 • 30 citations

Adverse events in users of sertraline: results from an observational study in psychiatric practice in The Netherlands

2002 • 27 citations

Nausea and Vomiting Associated With Selective Serotonin Reuptake Inhibitors

1997 • 27 citations

Late-Life Depression: Rationalizing Pharmacological Treatment Options

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Alopecia associated with treatment with selective serotonin reuptake inhibitors (SSRIs)

2006 • 26 citations

Fluoxetine in Medically Stable, Depressed Geriatric Patients

1997 • 26 citations

Selective Serotonin Reuptake Inhibitors in Older Patients

1997 • 25 citations

Memory Loss in a Patient Treated with Fluoxetine

2003 • 22 citations

Influence of Histamine and Serotonin Antagonists on the Growth of Xenografted Human Colorectal Tumors<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 20 citations

Length of Therapy with Selective Serotonin Reuptake Inhibitors and Tricyclic Antidepressants in Australia

2004 • 20 citations

Reversal of Citalopram-Induced Junctional Bradycardia with Intravenous Sodium Bicarbonate

2004 • 19 citations

Effect of Nortriptyline and Paroxetine on CYP2D6 Activity in Depressed Elderly Patients

2002 • 19 citations

Effects of serotonin on cerebral circulation after middle cerebral artery occlusion

1997 • 18 citations

Effects of Nortriptyline and Paroxetine on Postural Sway in Depressed Elderly Patients

2002 • 17 citations

Severe Life-Threatening Hyponatremia during Paroxetine Therapy

1999 • 15 citations

Clinical comparison of selective serotonin reuptake inhibitors in the treatment of geriatric depression: a review of literature

2000 • 3 citations

Discontinuation reactions associated with SSRIs.

1998 • 1 citations