Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

The Metabolic Basis of Inherited Disease

1979 • 2,083 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Receptor-Mediated Control of Cholesterol Metabolism

1976 • 957 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

1976 • 618 citations

Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

1974 • 589 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Disturbances in Lipid and Lipoprotein Metabolism

1978 • 482 citations

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

1975 • 477 citations

Lipoprotein structure and metabolism.

1976 • 429 citations

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

1975 • 382 citations

Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.

1977 • 380 citations

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

1975 • 364 citations

Regulation of Cholesterol Metabolism

1970 • 358 citations

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

1973 • 348 citations

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

1976 • 323 citations

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

1975 • 317 citations

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

1975 • 306 citations

Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia

1974 • 287 citations

HORMONE-PRODUCING CULTURES OF ADRENAL AND PITUITARY TUMOR ORIGIN

1962 • 285 citations

Clonal analysis of differentiated function in animal cell cultures. I. Possible correlated maintenance of differentiated function and the diploid karyotype.

1966 • 278 citations

Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.

1976 • 265 citations

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

1977 • 239 citations

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

1978 • 211 citations

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

1975 • 210 citations

Lipoprotein-mediated regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesteryl ester metabolism in the adrenal gland of the rat.

1977 • 207 citations

Control of Bovine Adrenal Cortical Cell Proliferation by Fibroblast Growth Factor. Lack of Effect of Epidermal Growth Factor

1977 • 201 citations

Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants.

1977 • 195 citations

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle.

1978 • 195 citations

The LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism

1976 • 183 citations

The Origin of Cholesterol in Liver, Small Intestine, Adrenal Gland, and Testis of the Rat: Dietary versus Endogenous Contributions

1959 • 183 citations

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue*

1979 • 173 citations

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. I. Receptor-Mediated Uptake of Low Density Lipoprotein and Utilization of Its Cholesterol for Steroid Synthesis in Cultured Adrenocortical Cells*

1979 • 163 citations

THE BIOLOGICAL CONVERSION OF CHOLESTEROL TO PREGNANEDIOL

1945 • 152 citations

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.

1976 • 150 citations

Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes

1977 • 145 citations

Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia.

1978 • 144 citations

Adrenal cholesterol uptake from plasma lipoproteins: regulation by corticotropin.

1976 • 144 citations

Hormonal Control of Adrenocortical Cell Proliferation

1977 • 124 citations

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.

1976 • 111 citations

Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities.

1977 • 97 citations

Characterization of Adult Bovine Adrenocortical Cells Throughout Their Life Span in Tissue Culture*

1978 • 81 citations

Stimulation of Adrenal Cholesterol Uptake from Plasma by Adrenocorticotrophin

1970 • 78 citations

Evidence for regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in nonhepatic tissues of rat.

1976 • 76 citations

ACTH and the Metabolism of Adrenal Cell Cultures

1970 • 76 citations

Studies on fatty liver induction by 4-aminopyrazolopyrimidine

1963 • 59 citations

Regulation of sterol synthesis in adrenal gland of the rat by both high and low density human plasma lipoproteins

1976 • 57 citations

High levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol synthesis in the ovary of the pregnant rabbit.

1978 • 54 citations

The effect of hypoxia on uptake and degradation of low density lipoproteins by cultured human arterial smooth muscle cells

1976 • 53 citations

Solubilization of apolipoprotein B and its specific binding by the cellular receptor for low density lipoprotein

1977 • 52 citations

Metabolism of adrenal cholesterol in man

1972 • 45 citations

The cyanogen bromide peptides of the apoprotein of low density lipoprotein (apoB): Its molecular weight from a chemical view

1978 • 39 citations

Familial hypercholesterolemia: model for genetic receptor disease.

1979 • 34 citations

Interactions of native and modified human low density lipoproteins with human skin fibroblasts

1978 • 31 citations

Studies of the cyanogen bromide fragments of the apoprotein of human serum low density lipoproteins

1978 • 30 citations

Metabolism of adrenal cholesterol in man

1972 • 25 citations

Equilibration of plasma and adrenal cholesterol in man.

1970 • 22 citations

Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

1977 • 20 citations