Mutations affecting the binding, internalization, and lysosomal hydrolysis of low density lipoprotein in cultured human fibroblasts, lymphocytes, and aortic smooth muscle cells

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

THE SMOOTH MUSCLE CELL

1971 • 1,571 citations

Atherosclerosis and the Arterial Smooth Muscle Cell

1973 • 1,503 citations

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

The Metabolic Basis of Inherited Disease.

1972 • 1,407 citations

Receptor-Mediated Control of Cholesterol Metabolism

1976 • 957 citations

Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts

1977 • 688 citations

Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans

1976 • 618 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

1975 • 477 citations

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

1975 • 382 citations

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

1975 • 364 citations

Localization of low density lipoprotein receptors on plasma membrane of normal human fibroblasts and their absence in cells from a familial hypercholesterolemia homozygote.

1976 • 323 citations

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

1975 • 317 citations

Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia

1974 • 287 citations

Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.

1976 • 265 citations

Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man

1974 • 253 citations

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

1975 • 245 citations

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein

1976 • 221 citations

Familial Hypercholesterolemia: A Genetic Defect in the Low-Density Lipoprotein Receptor

1976 • 220 citations

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

1975 • 210 citations

The LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism

1976 • 183 citations

Deficiency of an Acid Lipase in Wolman's Disease

1969 • 182 citations

Transiently Reduced Activity of Carbamyl Phosphate Synthetase and Ornithine Transcarbamylase in Liver of Children with Reye's Syndrome

1976 • 143 citations

Lipoprotein uptake by cultured human arterial smooth muscle cells

1975 • 135 citations

Binding, internalization, and hydrolysis of low density lipoprotein in long-term lymphoid cell lines from a normal subject and a patient with homozygous familial hypercholesterolemia.

1976 • 111 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and the esterification of cholesterol in human long term lymphoid cell lines

1976 • 78 citations

Heterozygous familial hypercholesterolemia: Failure of normal allele to compensate for mutant allele at a regulated genetic locus

1976 • 74 citations

Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts.

1976 • 54 citations