Evidence for the Involvement of Fas Ligand and Perforin in the Induction of Vascular Leak Syndrome

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

1985 • 2,616 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2.

1986 • 534 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

1981 • 446 citations

Clinical effects and toxicity of interleukin-2 in patients with cancer

1986 • 359 citations

Interleukin 2-activated human lymphocytes exhibit enhanced adhesion to normal vascular endothelial cells and cause their lysis.

1987 • 219 citations

Neutrophils Kill Pulmonary Endothelial Cells by a Hydrogen-Peroxide-Dependent Pathway

1984 • 213 citations

IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity.

1994 • 198 citations

Dissection of an inflammatory process induced by CD8+ T cells

1990 • 187 citations

Role of Complement, Chemokines, & Regulatory Cytokines in Acute Lung Injury

1996 • 152 citations

Clinical Toxicity of Cytokines Used As Haemopoietic Growth Factors

1995 • 139 citations

T-cell-receptor-independent activation of cytolytic activity of cytotoxic T lymphocytes mediated through CD44 and gp90MEL-14.

1991 • 112 citations

Vasculitis in primary vasculitides, granulomatoses, and connective tissue diseases

1983 • 111 citations

Toxicity and therapeutic efficacy of high-dose interleukin 2. In vivo infusion of antibody to NK-1.1 attenuates toxicity without compromising efficacy against murine leukemia.

1989 • 103 citations

IL-2-activated human killer lymphocytes but not their secreted products mediate increase in albumin flux across cultured endothelial monolayers. Implications for vascular leak syndrome.

1989 • 90 citations

Activation of the complement system during immunotherapy with recombinant IL-2. Relation to the development of side effects.

1990 • 87 citations

Antibodies to CD44 trigger effector functions of human T cell clones.

1993 • 87 citations

The role of neutrophil membrane glycoprotein 150 (Gp-150) in neutrophil-mediated endothelial cell injury in vitro.

1985 • 71 citations

Double-negative T cells from MRL-lpr/lpr mice mediate cytolytic activity when triggered through adhesion molecules and constitutively express perforin gene.

1993 • 65 citations

CD44 is a cytotoxic triggering molecule in human peripheral blood NK cells.

1994 • 62 citations

Enhancement of natural killer activity by an antibody to CD44.

1993 • 61 citations

Tumor Necrosis Factor-α Plays a Central Role in Interleukin-2-Induced Pulmonary Vascular Leak and Lymphocyte Accumulation

1994 • 53 citations

Perforin expression localizing cytotoxic lymphocytes in the intimas of coronary arteries with transplant-related accelerated arteriosclerosis

1993 • 45 citations

Sequential study of vasculitis in MRL mice

1987 • 45 citations

Cytotoxicity of T cells for cerebral endothelium in multiple sclerosis

1993 • 32 citations

Interleukin-2-induced lung injury. The role of complement.

1994 • 28 citations

Evidence for major alterations in the thymocyte subpopulations in murine models of autoimmune diseases

1990 • 25 citations

Characterization of factors regulating successful immunotherapy using a tumor‐specific cytotoxic T lymphocyte clone: Role of interleukin‐2, cycling pattern of lytic activity and adhesion molecules

1995 • 20 citations

MEDIATION OF INCREASED VASCULAR PERMEABILITY IN INFLAMMATION

1973 • 20 citations

Nonspecific Cytotoxicity of Recombinant Interleukin-2 Activated Lymphocytes

1989 • 17 citations

Interleukin-2-Induced Lymphocyte Infiltration of Multiple Organs Is Differentially Suppressed by Soluble Tumor Necrosis Factor Receptor

1994 • 15 citations

Interleukin‐2 activated human killer lymphocytes: Lack of involvement of interferon in the development of IL‐2‐activated killer lymphocytes

1987 • 13 citations

Interleukin-la Reduces the Severity of the Vascular Leak Syndrome Produced by Interleukin-2 and Interleukin-2 Plus Interferon-a

1994 • 12 citations

Fas and FasL Interactions in Cytotoxicity and its Role in Lymphoproliferative Disease

1996 • 7 citations