Stereochemical Factors in Biological Activity

Methods of Biochemical Analysis

1956 • 4,535 citations

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

Einfluss der Configuration auf die Wirkung der Enzyme

1894 • 1,695 citations

The Specificity of Serological Reactions

1945 • 1,104 citations

Steric effects in organic chemistry

1957 • 1,102 citations

STERIC EFFECTS IN ORGANIC CHEMISTRY

1962 • 1,091 citations

Determination of Serum Glycoproteins

1955 • 1,078 citations

STEREOCHEMISTRY AND THE MECHANISM OF ENZYMATIC REACTIONS

1953 • 971 citations

Enzymes: Units of Biological Structure and Function

1956 • 526 citations

Studies on the relationship between chemical constitution and physiological action

1933 • 437 citations

The Mechanism of Enzyme Action

1954 • 429 citations

Interpretation of Experiments on Metabolic processes, using Isotopic Tracer Elements

1948 • 425 citations

YEAST ALCOHOL DEHYDROGENASE: MOLECULAR WEIGHT, COENZYME BINDING, AND REACTION EQUILIBRIA

1954 • 373 citations

PURIFICATION AND PROPERTIES OF 5-NUCLEOTIDASE

1951 • 357 citations

Synthetic Analgesics: Stereochemical Considerations

1954 • 331 citations

THE INHIBITION OF ARGINASE BY AMINO ACIDS

1945 • 327 citations

Untersuchungen über den Stoffwechsel der Aminosäuren im Tierkörper. Mit 2 Figuren im Text.

1933 • 294 citations

BACTERIAL PERMEASES

1957 • 257 citations

THE ENZYMATIC TRANSFER OF HYDROGEN

1953 • 240 citations

The free-energy changes for the reduction of diphosphopyridine nucleotide and the dehydrogenation of <scp>l</scp>-malate and <scp>l</scp>-glycerol 1-phosphate

1953 • 234 citations

Chemistry of the Carbohydrates

1948 • 210 citations

Natural Products Related to Phenanthrene

1950 • 201 citations

Optical Isomerism and Pharmacological Action, a Generalization

1956 • 194 citations

A New Series of Potent Analgesics

1957 • 181 citations

Biosynthesis and Structure of Lipoic Acid Derivatives¹

1956 • 180 citations

STUDIES ON LACTIC DEHYDROGENASE OF HEART

1952 • 176 citations

Antibiotics and chemotherapy.

1953 • 176 citations

The Interaction of Purified Antibody with Optically Isomeric Haptens^1,2

1956 • 168 citations

PROGRESS IN STEREOCHEMISTRY

1962 • 165 citations

Cyto-active amino-acid and peptide derivatives. Part I. Substituted phenylalanines

1954 • 163 citations

Stereochemistry of Amino Acids

1948 • 162 citations

THE BIOLOGICAL CONVERSION OF l-SERINE TO GLYCINE

1946 • 157 citations

Influence of Optically Active Acyl Groups on the Enzymatic Hydrolysis of N-Acylated-L-amino Acids

1954 • 157 citations

THE STEREOSPECIFICITY OF ENZYMATIC HYDROGEN TRANSFER FROM DIPHOSPHOPYRIDINE NUCLEOTIDE

1957 • 146 citations

PHYTOHORMONES: STRUCTURE AND PHYSIOLOGICAL ACTIVITY. I

1938 • 135 citations

Progress in Stereochemistry.

1955 • 134 citations

l-AMINO ACID OXIDASE OF PROTEUS VULGARIS

1944 • 132 citations

Studies of the Enzyme Fumarase. III.¹ The Dependence of the Kinetic Constants at 25° upon the Concentration and pH of Phosphate Buffers

1954 • 130 citations

ON THE STRUCTURE OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE

1954 • 129 citations

ON PROTEOLYTIC ENZYMES

1937 • 119 citations

A Tissue Culture from Potato Tuber: The Synergistic Action of 2,4-D and of Coconut Milk

1951 • 119 citations

STUDIES ON THE ENZYME ENOLASE

1957 • 119 citations

The Relation of Chemical Structure to Bio-Logical Activity in Growth Substances

1953 • 114 citations

SOME SYNTHETIC AND HYDROLYTIC EXPERIMENTS WITH CHYMOTRYPSIN

1938 • 112 citations

Protein Structure in Relation to Function and Biosynthesis

1956 • 106 citations

ON THE MECHANISM OF ACTION OF PHOSPHOGLUCOSE ISOMERASE AND PHOSPHOMANNOSE ISOMERASE

1957 • 104 citations

Oxidative Degradation of Testosterone by Adaptive Enzymes

1952 • 104 citations

ACETYLCHOLINESTERASE

1950 • 99 citations

Oxidation of alcohols by yeast alcohol dehydrogenase and by the living cell. The thiol groups of the enzyme

1952 • 99 citations

Über eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen, I

1949 • 96 citations

Azaserine, A New Tumour-Inhibitory Substance: Studies with Crocker Mouse Sarcoma 180

1954 • 95 citations

THE ENZYMATIC TRANSFER OF HYDROGEN

1953 • 91 citations

Biological Relations of Optically Isomeric Substances.

1926 • 90 citations

The Breakdown of Naphthalene by a Soil Bacterium

1953 • 85 citations

ON THE MECHANISM OF ENZYMATIC CYCLIZATION OF SQUALENE

1957 • 84 citations

Amides of vegetable origin. Part V. Stereochemistry of conjugated dienes

1955 • 83 citations

PHARMACOLOGY OF METHADONE AND RELATED COMPOUNDS

1948 • 81 citations

THE EFFECT OF pH ON FUMARASE ACTIVITY IN ACETATE BUFFER

1955 • 77 citations

Biosynthesis of Asymmetric Citric Acid: a Substantiation of the Ogston Concept

1949 • 77 citations

A Comparative Study of the Three Stereoisomeric 1,4-Diphenylbutadienes

1948 • 76 citations

THE SPECIFICITY OF CARBOXYPEPTIDASE

1946 • 75 citations

INHIBITION OF PROSTATIC ACID PHOSPHATASE BY α-HYDROXYCARBOXYLIC ACIDS

1957 • 75 citations

Analgesics and their Antagonists: Some Steric and Chemical Considerations

1956 • 73 citations

Antispasmodics. I. Bicyclic Basic Alcohols^*

1952 • 73 citations

OPTICAL PURITY OF AMINO ACID ENANTIOMORPHS

1951 • 70 citations

Analgesics and their Antagonists: Some Steric and Chemical Considerations: P<scp>art</scp>

1956 • 69 citations

Quantitative observations on thyroxine and allied substances

1930 • 69 citations

The Optical Rotation and Configuration of a Pure Enantiomorph of Ethanol-1-d^1,2,3

1957 • 67 citations

PIPERIDINE DERIVATIVES. V. 1,3-DIALKYL-4-ARYL-4-ACYLOXYPIPERIDINES

1947 • 65 citations

Analgesics and their antagonists: some steric and chemical considerations. III. The influence of the basic group on the biological response.

1956 • 65 citations

Analgesics and their Antagonists: Some Steric and Chemical Considerations

1956 • 65 citations

A Method for the Determination of the Configuration of Organic Molecules using ‘Stereo-selective Adsorbents’

1957 • 65 citations

Pharmacology of Lysergic Acid Diethylamide and Some of Its Related CompoundS

1957 • 64 citations

The pH-dependence of enzymic ester hydrolysis

1956 • 62 citations

STUDIES ON THE SPECIFICITY OF CHOLINE ESTERASE

1938 • 62 citations

THE BIOSYNTHESIS OF CHOLINE FROM SERINE AND RELATED COMPOUNDS

1955 • 60 citations

CHEMISTRY AND PHARMACOLOGY OF THE METHADOLS¹ AND ACETYLMETHADOLS²

1952 • 59 citations

MICROBIOLOGICAL METHODS FOR THE DETERMINATION OF AMINO ACIDS

1945 • 58 citations

Liver arginase. IV. Effect of pH on kinetics of manganese-activated enzyme

1956 • 57 citations

The Stereoisomerism of Cyclohexane Derivatives.

1954 • 56 citations

The chemistry of the steroids

1957 • 56 citations

A NONENZYMATIC ILLUSTRATION OF “CITRIC ACID TYPE” ASYMMETRY: THE MESO-CARBON ATOM

1954 • 55 citations

Molecular structure and biological specificity

1947 • 55 citations

Yeast Alcohol Dehydrogenase. III. Relation of Alcohol Structure to Activity¹

1957 • 53 citations

181. Long-range effects in alicyclic systems. Part II. The rates of condensation of some triterpenoid ketones with benzaldehyde

1957 • 53 citations

l(—)-Cysteic acid decarboxylase

1942 • 53 citations

Enzymatic Racemization of β-Hydroxybutyryl-S-CoA and the Stereospecificity of Enzymes of the Fatty Acid Cycle¹

1955 • 52 citations

MICROBIOLOGICAL METHODS FOR THE DETERMINATION OF AMINO ACIDS

1946 • 51 citations

A NOTE ON THE ASYMMETRICAL METABOLISM OF GLYCEROL

1954 • 50 citations

Chemical Preparation of Asymmetrically Labeled Citric Acid¹

1950 • 50 citations

THE RELATIVE THYROIDAL POTENCY OF 1- AND d,1-THYROXINE¹

1945 • 50 citations

ENZYME CATALYSIS AND ENZYME SPECIFICITY-COMBINATION OF AMINO ACIDS AT THE ACTIVE SITE OF PHOSPHOGLUCOMUTASE¹

1957 • 49 citations

Synthetic Penicillin

1946 • 49 citations

Synthesis of (+)-α-Lipoic Acid and its Optical Antipode¹

1955 • 47 citations

ON THE MECHANISM OF THE ACONITASE AND ISOCITRIC DEHYDROGENASE REACTIONS

1957 • 47 citations

Wirkstoffprinzip und Pflanzenwachstum

1937 • 47 citations

Morphinantagonisten

1952 • 46 citations

STUDIES ON PLANT GROWTH‐REGULATING SUBSTANCES

1952 • 45 citations

A CHEMICAL REACTION OF HYDROXYLAMINE WITH DIPHOSPHOPYRIDINE NUCLEOTIDE

1954 • 44 citations

Die Totalsynthese des Tetrahydro‐desoxycodeins

1949 • 43 citations

The Specificity of Serological Reactions

1945 • 42 citations

STUDY ON THE CONFIGURATION OF EPHEDRINE¹

1932 • 41 citations

Beiträge zur Kenntnis der Arginase.

1925 • 41 citations

The Site of Enzymatic Hydrogen Transfer in Diphosphopyridine Nucleotide¹

1955 • 40 citations

The Acetylcholinesterase Surface. VI. Further Studies with Cyclic Isomers as Inhibitors and Substrates^1,2

1956 • 40 citations

Puromycin. Synthetic Studies. X. A Novel Breakdown of the Purine Ring System

1955 • 40 citations

Progress in Stereochemistry.

1958 • 39 citations

Isotopic exchange criteria for enzyme mechanisms

1955 • 39 citations

Optically Active Compounds Related to Methadon

1949 • 38 citations

Studies of the Enzyme Fumarase. VI.¹ Study of the Incorporation of Deuterium into L-Malate during the Reaction in Deuterium Oxide^2,3

1957 • 37 citations

MODE OF ACTION OF CHLORAMPHENICOL II

1954 • 37 citations

The Preparation and Properties of Some Benzohydryl Sulfones

1948 • 36 citations

SEROLOGICAL DIFFERENTIATION OF STERIC ISOMERS (ANTIGENS CONTAINING TARTARIC ACIDS)

1929 • 35 citations

196. Long-range effects in alicyclic systems. Part I. The rates of rearrangement of some steroidal dibromides

1956 • 35 citations

Strong Analgesics. The Preparation of Some Ethyl 1-Aralkyl-4-phenylpiperidine-4-carboxylates¹

1957 • 34 citations

The Synthesis and Resolution of 3-Hydroxy-N-methylisomorphinan¹

1958 • 33 citations

426. The configuration of adrenaline and of its p-hydroxyphenyl analogue

1958 • 33 citations

The Pharmacology of Tropane Compounds in Relation to Their Steric Structure

1957 • 32 citations

THE SYNTHESIS AND METABOLISM OF ENANTIOMORPHIC FORMS OF GLYCEROL-1-C14

1957 • 32 citations

The Reactions of Antiserum Homologous to the p-Azosuccinanilate Ion Group^1a

1948 • 31 citations

Zur Kenntnis der optischen Isomeren des Arginins und Ornithins.

1906 • 30 citations

The Mechanism of the Stereospecific Enzymatic Hydration of Fumarate to L-Malate¹

1957 • 30 citations

The Preparation of Hydroxyphenylserines from Benzyloxybenzaldehydes and Glycine¹

1954 • 29 citations

SPECIFICITY OF PAPAIN-CATALYZED TRANSAMIDATION REACTIONS

1957 • 29 citations

The antibacterial activity of the isomers of chloramphenicol.

1954 • 29 citations

Piperidine Derivatives. IV. 1,3-Disubstituted-4-aryl-4-acyloxy Piperidines^*1

1957 • 29 citations

The Stereochemistry of Asymmetric Phosphorus Compounds. II. Stereospecificity in the Irreversible Inactivation of Cholinesterases by the Enantiomorphs of an Organophosphorus Inhibitor

1958 • 28 citations

Alpha- and Beta-Prodine Type Compounds

1959 • 28 citations

Configurational studies in synthetic analgesics

1955 • 28 citations

Stereochemistry of Certain Analgesics

1954 • 27 citations

SERINE METABOLISM IN RAT LIVER SLICES

1957 • 26 citations

Separation of cis and trans Stilbenes by Application of the Chromatographic Brush Method

1942 • 26 citations

Partially hydrogenated naphthoic acids and α‐alkyl‐phenylacetic acids: Researches on plant growth regulators XIX. Structure/activity IV

1951 • 25 citations

The Resolution of Methadone and Related Compounds

1948 • 25 citations

STUDIES ON THE BIOSYNTHESIS OF ARTERENOL. ENZYMATIC DECARBOXYLATION OF DIASTEREO-ISOMERS OF HYDROXYPHENYLSERINES¹

1955 • 25 citations

Ueber das Verhalten stereo-isomerer Substanzen im Thierkörper. I. Mittheilung. Ueber das Schicksal der 3 Arabinosen im Kaninchenleibe.

1902 • 24 citations

A SYNTHESIS OF l(+)-GLUTAMINE

1946 • 24 citations

Coplanarity and Chromatographic Adsorbability of Some Isomeric Naphthyl-cycloalkenes and Polycyclic Aromatic Hydrocarbons^1,2

1957 • 23 citations

Optical Isomers of Amidone, with a Note on isoAmidone

1947 • 23 citations

Eine einfache enzymatische Methode zur Herstellung von <scp>D</scp>‐ und <scp>L</scp>‐Tryptophan

1948 • 22 citations

THE CARBOHYDRATES OF GONOCOCCUS AND MENINGOCOCCUS

1934 • 21 citations

Über die Antipoden der α-(β′ Indolyl)-propionsäure und ihre verschieden starke physiologische Wirksamkeit. 38. Mitteilung über pflanzliche Wachstumsstoffe

1944 • 21 citations

Remarks on chemical specificity

1950 • 21 citations

THE SYNTHESIS AND ENZYMATIC HYDROLYSIS OF POLY-d-LYSINE

1956 • 21 citations

AMINO ALCOHOLS. XII. OPTICAL ISOMERS IN THE EPHEDRINE SERIES OF COMPOUNDS (1)

1943 • 21 citations

Biotin. VII. A Stereochemical Correlation of dl-Biotin, dl-Allobiotin and dl-epi-Allobiotin

1945 • 20 citations

The origin of steric hindrance in cyclohexane derivatives

1953 • 19 citations

Resolution of Isopropyl Nor-Adrenaline into Optical Isomers and Their Pharmacological Potency Ratio

1953 • 19 citations

Alpha- and Beta-Prodine Type Compounds: Configurational Studies

1957 • 19 citations

Kinetics and Equilibria in Flavoprotein Systems. III. The Effects of Chemical Modifications of the Apoprotein on the Dissociation and Reassociation of the Old Yellow Enzyme.

1955 • 19 citations

Spaltung des Leucinesters durch Pankreasferment.

1906 • 18 citations

The Enzymatic Synthesis of N-Acyl-D- and L-Phenylalanylphenylhydrazides¹

1950 • 18 citations

Biological Activity of Synthetic d, 1-Desthiobiotin

1945 • 18 citations

On the Stereochemistry of the Isocitric and Alloisocitric Lactones

1955 • 18 citations

STUDIES ON THE INCORPORATION OF C14 ADMINISTERED AS l-SORBOSE INTO l-ASCORBIC ACID AND d-GLUCOSE IN RATS

1955 • 17 citations

196. Über den enzymatischen Abbau von l‐α‐Oxysäuren)

1946 • 16 citations

The Separation of Substituted threo- and erythro-Phenylserines by Paper Chromatography. The Configuration of Arterenol and Epinephrine

1955 • 16 citations

The Correlation of Configurations of Chloroamphenicol and D-Serine

1956 • 15 citations

2‐Phenyl‐cyclopropane‐1‐carboxylic acids: Researches on plant growth regulators XX. Structure/activity V

1951 • 14 citations

The Isomethadols and their Acetyl Derivatives

1952 • 14 citations

Über Steroide. 52. Mitteilung. Die Spaltung des Racemates der n‐Bisdehydro‐doisynolsäure. Über östrogene Carbonsäuren X

1946 • 14 citations

Geometrical Isomers in a Series of Antihistamines

1951 • 13 citations

The Resolution of Ethyl 1,1-Diphenyl-3-dimethylaminobutyl Sulfone

1948 • 13 citations

Strong Analgesics. The Preparation of Some 4-Acyloxy-1-aralkyl-4-phenylpiperidines

1958 • 13 citations

Optical Activity of Excreted Mepacrine

1945 • 12 citations

The Acetylcholinesterase Surface. VII. Interference with the Surface Binding as Reflected by Enzymatic Response to Turicine, Betonicine and Related Heterocycles¹

1957 • 12 citations

Analgesics. II. A New Synthesis of Aminophthalidylalkanes

1948 • 11 citations

The Metabolic Fate of a Hexamethylenimine Analgesic*†*Wyeth Institute for Medical Research, Radnor, Pa.†Ethoheptazine, Wyeth Laboratories.

1958 • 11 citations

Biological Oxidations

1956 • 10 citations

A New Species of the Genus Bacillus Exhibiting Mobile Colonies on the Surface of Nutrient Agar

1935 • 10 citations

RESOLUTION OF RACEMIC PHENYLALANINE

1950 • 10 citations

Specific Action of Optical Isomers of Mepacrine upon Dextral and Sinistral Strains of Bacillus mycoides Flügge

1946 • 10 citations

Synthesis of Azacycloheptane Derivatives Related to Piperidine Analgesics^1,2

1957 • 10 citations

Plant Growth Substances

1938 • 10 citations

Transformation of 1-Bromosinameneine into (+)-Morphine

1957 • 9 citations

The Configuration of Alphaprodine and Betaprodine

1955 • 9 citations

Die Linksmandelsäure und das optische Drehungsvermögen derselben

1883 • 8 citations

600. Configurational studies in synthetic analgesics. Part III. The configuration of (–)-phenadoxone

1957 • 8 citations

162. Configurational studies in synthetic analgesics : the synthesis of (–)-methadone from<scp>D</scp>-(–)-alanine

1957 • 8 citations

Sweetness and Configuration in Rhamnose

1954 • 8 citations

Studies on Diastereoisomeric α-Amino Acids and Corresponding α-Hydroxy Acids. III. Configuration of the β-Asymmetric Center of Isoleucine

1955 • 8 citations

Optical isomers of cysteine in the prevention of leukopenia induced by nitrogen mustard.

1954 • 6 citations

REACTIONS OF ALKOXIDES WITH CERTAIN HYDROGENATED ALKALOIDS OF THE MORPHINE SERIES

1951 • 6 citations

Chloromycetin.¹ The Synthesis of p-Phenoxy and p-Methoxy Compounds

1952 • 6 citations

310. The selective absorption of optical antipodes by proteins. Part II

1953 • 5 citations

The Steric Configuration of β-Benzoylpropionate Ion in Aqueous Solution as Determined by Immunochemical Means^1,2

1953 • 5 citations

Relative Activities of l- and dl-Thyroxine

1947 • 4 citations

Metabolism of 5 : 5-Diphenylhydantoin in the Rabbit

1957 • 4 citations

Chemical Specificity in Biological Reactions

1955 • 4 citations

Selective Absorption of Optical Antipodes by Proteins

1954 • 2 citations