A three-dimensional model to analyze drug-drug interactions

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1984 • 6,841 citations

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1979 • 912 citations

The problem of synergism and antagonism of combined drugs.

1953 • 906 citations

Analysis of combined drug effects: a new look at a very old problem

1983 • 593 citations

The expected effect of a combination of agents: the general solution

1985 • 516 citations

ENZYME AND METABOLIC INHIBITORS

1964 • 504 citations

Criteria for Analyzing Interactions between Biologically Active Agents

1981 • 454 citations

ANTAGONISTS OF NUCLEIC ACID DERIVATIVES

1954 • 427 citations

Percent Agreement, Pearson's Correlation, and Kappa as Measures of Inter-examiner Reliability

1986 • 270 citations

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon

1987 • 237 citations

The employment of combinations of drugs in the chemotherapy of neoplasia: a review.

1957 • 122 citations

The Use of Combinations of Antimicrobial Drugs

1968 • 118 citations

Synergistic antiviral effects of ribavirin and the C-nucleoside analogs tiazofurin and selenazofurin against togaviruses, bunyaviruses, and arenaviruses

1984 • 101 citations

A rapid and automated colorimetric assay for evaluating the sensitivity of herpes simplex strains to antiviral drugs

1986 • 98 citations

A Statistical Approach to the Construction and Analysis of Isobolograms

1988 • 88 citations

Synergism and potentiation with special reference to the combination of structural analogues.

1956 • 86 citations

A Straightforward Method for the Study of Drug Interactions: An Isobolographic Analysis Primer

1988 • 71 citations

Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition.

1985 • 63 citations

Automated, quantitative cytopathic effect reduction assay for interferon

1982 • 56 citations

Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis

1986 • 52 citations

AN ANALYSIS OF FUNCTIONAL ANTAGONISM AND SYNERGISM

1981 • 51 citations

Broad-spectrum synergistic antiviral activity of selenazofurin and ribavirin

1984 • 48 citations

Combination therapy: some concepts and results.

1974 • 45 citations

Structure-Activity Relationships among -(N)-Heterocyclic Acyl Thiosemicarbazones and Related Compounds as Inhibitors of Herpes Simplex Virus Type 1-specified Ribonucleoside Diphosphate Reductase

1986 • 42 citations

[71] Objective antiviral assay of the interferons by computer assisted data collection and analysis

1986 • 37 citations

Synergism between anti-rhinovirus antivirals: Various human interferons and a number of synthetic compounds

1986 • 34 citations

A kinetic model of regulation of the deoxyribonucleoside triphosphate pool composition

1984 • 31 citations

Isobolographic, Algebraic, and Search Methods in the Analysis of Multiagent Synergy

1988 • 31 citations

Isolation of herpes simplex virus clones and drug resistant mutants in microcultures

1975 • 31 citations

Evaluation of the anti-herpesvirus drug combinations: Virazole plus arabinofuranosylhypoxanthine and Virazole plus arabinofuranosyladenine

1982 • 26 citations

Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1

1988 • 23 citations

Enhanced efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine in combination with gamma interferon against herpes simplex virus type 2 in mice

1985 • 20 citations

The interaction of radiations of different LET

1987 • 19 citations

Quantitation of dye binding by cell monolayers in a microtiter system

1986 • 19 citations

The need for new antiviral agents

1985 • 15 citations

Application of response surface methodology to the assay of gamma-glutamyltransferase.

1982 • 14 citations

Effects of N-Trifluoroacetyladriamycin-14-O-Hemiadipate and Radiation on L1210 Cells

1986 • 13 citations

Synergistic Inhibition of Anatid Herpesvirus Replication by Acyclovir and Phosphonocompounds

1987 • 8 citations

The interaction between full and partial inhibitors acting on a single enzyme. A theoretical analysis.

1983 • 7 citations

Interaction between drugs using three-dimensional isobolographic interpretation.

1973 • 7 citations

A rapid antiviral drug test by enzyme-linked immunoassay.

1983 • 5 citations

Application of Response Surface Methods for Evaluating the Interactions of Soman, Atropine, and Pralidioxime Chloride

1985 • 2 citations