Principles of Pharmacology

Prediction of Creatinine Clearance from Serum Creatinine

1976 • 15,066 citations

Prevention of Stroke by Antihypertensive Drug Treatment in Older Persons With Isolated Systolic Hypertension

1991 • 2,850 citations

Compliance in Health Care

1980 • 1,829 citations

Longitudinal Studies on the Rate of Decline in Renal Function with Age

1985 • 1,531 citations

The Effect of Age on Creatinine Clearance in Men: A Cross-sectional and Longitudinal Study

1976 • 1,111 citations

A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women

1991 • 1,024 citations

Psychotropic Drug Use and the Risk of Hip Fracture

1987 • 1,013 citations

Atrial Fibrillation: A Major Contributor to Stroke in the Elderly

1987 • 1,005 citations

Risk Factors for Intracranial Hemorrhage in Outpatients Taking Warfarin

1994 • 926 citations

Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors

1993 • 795 citations

Dose-Response Effect of Adjuvant Chemotherapy in Breast Cancer

1981 • 765 citations

Risk Factors for Complications of Chronic Anticoagulation: A Multicenter Study

1993 • 682 citations

A Metaanalysis of Controlled Trials of Neuroleptic Treatment in Dementia

1990 • 653 citations

Serum Albumin Level and Physical Disability as Predictors of Mortality in Older Persons

1994 • 635 citations

Comparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee

1991 • 633 citations

Reduced β‐adrenoceptor sensitivity in the elderly

1979 • 621 citations

Drug Disposition in Old Age

1982 • 589 citations

Benzodiazepines of Long and Short Elimination Half-life and the Risk of Hip Fracture

1989 • 551 citations

The Exclusion of the Elderly and Women From Clinical Trials in Acute Myocardial Infarction

1992 • 506 citations

Association of Acetaminophen Hepatotoxicity With Fasting and Ethanol Use

1994 • 443 citations

A Randomized Trial of a Program to Reduce the Use of Psychoactive Drugs in Nursing Homes

1992 • 401 citations

Withdrawal Reaction after Long-Term Therapeutic Use of Benzodiazepines

1986 • 371 citations

Prescribing for the Elderly Part I: Sensitivity of the Elderly to Adverse Drug Reactions*

1988 • 330 citations

Adverse Drug Reactions Associated with Global Cognitive Impairment in Elderly Persons

1987 • 328 citations

The Ambiguous Relation between Aging and Adverse Drug Reactions

1991 • 323 citations

Increased sensitivity to nitrazepam in old age.

1977 • 323 citations

Antipyrine metabolism in man: Influence of age, alcohol, caffeine, and smoking

1975 • 320 citations

Duodenal and Gastric Ulcer Prevention with Misoprostol in Arthritis Patients Taking NSAIDs

1993 • 300 citations

A study of antipsychotic drug use in nursing homes: epidemiologic evidence suggesting misuse.

1980 • 296 citations

Clinical trials and drug toxicity in the elderly. The experience of the eastern cooperative oncology group

1983 • 282 citations

Treatment for glaucoma: adherence by the elderly.

1993 • 274 citations

Influence of Age on Pain Relief From Analgesics

1971 • 265 citations

Age as a determinant of sensitivity to warfarin.

1977 • 263 citations

Sensitivity to Triazolam in the Elderly

1991 • 261 citations

Toxicity of high‐dose flurazepam in the elderly

1977 • 243 citations

Aging and the Anticoagulant Response to Warfarin Therapy

1992 • 240 citations

Chemotherapy of Metastatic Breast Cancer in the Elderly

1992 • 201 citations

Changes in Antipsychotic Drug Use in Nursing Homes During Implementation of the OBRA-87 Regulations

1994 • 197 citations

Age and morphine analgesia in cancer patients with postoperative pain

1980 • 195 citations

Is digoxin really important in treatment of compensated heart failure?

1982 • 193 citations

Psychoactive Medication Use in Intermediate-Care Facility Residents

1988 • 180 citations

Clinical Pharmacokinetics of Anxiolytics and Hypnotics in the Elderly

1991 • 177 citations

Clinical Pharmacokinetics of Anxiolytics and Hypnotics in the Elderly

1991 • 175 citations

Fatal cholestatic jaundice in elderly patients taking benoxaprofen.

1982 • 165 citations

Reducing Antipsychotic Drug Use in Nursing Homes

1993 • 163 citations

Improving Medication Prescribing and Utilization in the Nursing Home

1990 • 161 citations

Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs

1981 • 153 citations

Resident Behavior and Staff Distress in the Nursing Home

1991 • 151 citations

Medication Usage in an Elderly Population

1985 • 142 citations

Increased Antidepressant Use in Patients Prescribed β-Blockers

1986 • 140 citations

Importance of Protein Binding for the Interpretation of Serum or Plasma Drug Concentrations

1982 • 133 citations

Medication Use By Ambulatory Elderly

1986 • 133 citations

Central Nervous System Reactions to Histamine-2 Receptor Blockers

1991 • 133 citations

Nonsteroidal Anti-inflammatory Drug—Associated Azotemia in the Very Old

1990 • 126 citations

The Impact of Research Quality and Study Design on Epidemiologic Estimates of the Effect of Nonsteroidal Anti-inflammatory Drugs on Upper Gastrointestinal Tract Disease

1992 • 124 citations

Psychotropic Drug Practice In Nursing Homes

1988 • 123 citations

The Effect of Age On Serum Albumin in Healthy Males: Report From The Normative Aging Study

1988 • 121 citations

The impact of antipsychotic drug regulations on psychotropic prescribing practices in nursing homes

1992 • 120 citations

Effects of discontinuing maintenance digoxin therapy in patients with ischemic heart disease and congestive heart failure in sinus rhythm

1983 • 117 citations

Implications of Altered Drug Disposition in the Elderly: Studies of Benzodiazepines

1989 • 99 citations

Effect of Gradual Withdrawal on the Rebound Sleep Disorder after Discontinuation of Triazolam

1987 • 94 citations

The Impact of OBRA on Medical Practice within Nursing Facilities

1992 • 94 citations

Knowledge of and Compliance with Drug Regimens in the Elderly

1982 • 93 citations

Increased Prescribing of Antidepressants Subsequent to ß-Blocker Therapy

1990 • 91 citations

Determinants of anticoagulant control in patients receiving warfarin.

1977 • 91 citations

Neuroleptic drug exposure and treatment of parkinsonism in the elderly: A case-control study

1995 • 87 citations

A Survey of the Prescribing and Administration of Drugs in a Long‐Term Care Institution for the Elderly

1975 • 82 citations

Correlation of Estimated Renal Function Parameters Versus 24‐Hour Creatinine Clearance in Ambulatory Elderly

1989 • 74 citations

Need for a large randomized trial to evaluate the effects of digitalis on morbidity and mortality in congestive heart failure

1992 • 72 citations

The Effects of Drug Counseling and Other Educational Strategies on Drug Utilization of the Elderly

1985 • 69 citations

Nursing Home Resources and Tranquilizer Use among the Institutionalized Elderly

1991 • 61 citations

Guideline-based Consultation To Prevent Anticoagulant-related Bleeding

1992 • 55 citations

Physician Visits to Nursing Homes

1982 • 48 citations

Diphenhydramine: Kinetics and psychomotor effects in elderly women

1982 • 45 citations

Antithrombotic Therapy

1995 • 43 citations

Protein Intake and Serum Albumin Levels in the Elderly

1977 • 42 citations

THE EFFECT OF AGEING ON DRUG ABSORPTION FROM THE GUT

1977 • 42 citations

Clinical Assessment of Extrapyramidal Signs in Nursing Home Patients Given Antipsychotic Medication

1994 • 41 citations

Clinical Geriatric Psychopharmacology

1985 • 38 citations

Clinical Issues Related to Discontinuing Digoxin Therapy in Elderly Nursing Home Patients

1991 • 30 citations

The nonpharmacologic basis of therapeutics

1972 • 30 citations

OBRA 87 ‐ A Commentary

1991 • 15 citations

WITHDRAWAL OF ANTIHYPERTENSIVE DRUGS IN MILD HYPERTENSION

1981 • 6 citations