CRE-decoy oligonucleotide-inhibition of gene expression and tumor growth

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

CREB: a Ca ²⁺ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases

1991 • 1,476 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity.

1994 • 718 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

Common DNA binding site for Fos protein complexesand transcription factor AP-1

1988 • 613 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Specific Recognition of Cruciform DNA by Nuclear Protein HMG1

1989 • 596 citations

A gene therapy strategy using a transcription factor decoy of the E2F binding site inhibits smooth muscle proliferation in vivo.

1995 • 490 citations

Therapeutic Applications of Oligonucleotides

1992 • 438 citations

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

1986 • 427 citations

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

1989 • 416 citations

MINIREVIEW: Cyclic AMP Response Element Binding Proteins: A Cornucopia of Transcription Factors

1990 • 394 citations

Regulation of Gene Expression with Double-Stranded Phosphorothioate Oligonucleotides

1990 • 373 citations

Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription.

1988 • 342 citations

Does antisense exist?

1995 • 257 citations

Mixed-backbone oligonucleotides as second generation antisense oligonucleotides: In vitro and in vivo studies

1997 • 225 citations

Oligonucleotide analogues as potential chemotherapeutic agents.

1988 • 221 citations

Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence

1988 • 218 citations

The inducible Iac operator-repressor system is functional in mammalian cells

1987 • 207 citations

Antisense therapeutics

1998 • 190 citations

DNA Bending by Fos and Jun: The Flexible Hinge Model

1991 • 186 citations

Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus

1988 • 169 citations

The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB.

1995 • 157 citations

Lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells

1987 • 141 citations

Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide

1999 • 125 citations

Involvement of p53 Expression in cAMP-Mediated Apoptosis in Immortalized Granulosa Cells

1995 • 103 citations

A dominant repressor of cyclic adenosine 3',5'-monophosphate (cAMP)- regulated enhancer-binding protein activity inhibits the cAMP-mediated induction of the somatostatin promoter in vivo

1992 • 99 citations

An E. coli Promoter That Regulates Transcription by DNA Superhelix-Induced Cruciform Extrusion

1988 • 95 citations

Specific sequences and a hairpin structure in the template strand are required for N4 virion RNA polymerase promoter recognition

1992 • 78 citations

Protein-Induced Bending as a Transcriptional Switch

1993 • 73 citations

Response of the human T-cell leukemia virus type 1 long terminal repeat to cyclic AMP

1989 • 72 citations

SV40 enhancer-binding factors are required at the establishment but not the maintenance step of enhancer-dependent transcriptional activation

1986 • 56 citations

Cross-talk between cAMP and p53-generated signals in induction of differentiation and apoptosis in steroidogenic granulosa cells

1996 • 48 citations

Hairpin formation within the enhancer region of the human enkephalin gene.

1991 • 46 citations

Differential activation of the 21-base-pair enhancer element of human T-cell leukemia virus type 1 by its owntrans-activator and cyclic AMP

1989 • 45 citations

CRE-Transcription Factor Decoy Oligonucleotide Inhibition of MCF-7 Breast Cancer Cells: Cross-Talk with p53 Signaling Pathway

2000 • 34 citations

Modulation of tax and PKA‐mediated expression of HTLV‐I promoter via cAMP response element binding and modulator proteins CREB and CREM

1995 • 25 citations

Electron microscopy reveals that transcription factor TFIIIA bends 5S DNA.

1989 • 20 citations

Multistep regulation of enhancer activity of the 21-base-pair element of human T-cell leukemia virus type I

1992 • 16 citations

A novel cyclic AMP response element-binding protein-1 (CREB-1) splice product may down-regulate CREB-1 activity

1995 • 10 citations