Pharmacological Characterization of Contractile Responses Induced by α1-Agonists, Norepinephrine and Clonidine, by Selective Antagonists of Their Subtypes in Rabbit Thoracic Aorta

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.

1988 • 566 citations

α1Adrenoceptor subtypes linked to different mechanisms for increasing intracellular Ca2+ in smooth muscle

1987 • 482 citations

Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.

1990 • 417 citations

Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.

1991 • 401 citations

α1-Adrenoceptor subclassification in vascular smooth muscle

1986 • 215 citations

Subclassification of α₁‐adrenoceptor recognition sites by urapidil derivatives and other selective antagonists

1989 • 213 citations

5-Methyl-urapidil discriminates between subtypes of the α1-adrenoceptor

1988 • 208 citations

(+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors

1989 • 173 citations

Subtypes of α1adrenoceptors in rat blood vessels

1990 • 141 citations

Identification of a single α₁‐adrenoceptor corresponding to the α_1A‐subtype in rat submaxillary gland

1989 • 110 citations

Lack of cross-desensitization between structurally dissimilar α-adrenoceptor agonists

1977 • 97 citations

RECEPTOR INTERACTIONS OF IMIDAZOLINES: α‐ADRENOCEPTORS OF RAT AND RABBIT AORTAE DIFFERENTIATED BY RELATIVE POTENCIES, AFFINITIES AND EFFICACIES OF IMIDAZOLINE AGONISTS

1982 • 68 citations

Differential Interactions of Clonidine and Methoxamine with the Postsynaptic α-Adrenoceptor of Rabbit Main Pulmonary Artery

1983 • 61 citations

?1B- but not ?1A-adrenoceptors mediate inositol phosphate generation

1990 • 59 citations

Two distinct α₁‐adrenoceptor subtypes involved in noradrenaline contraction of the rabbit thoracic aorta

1990 • 58 citations

Alpha adrenergic receptor subtype associated with receptor binding, Ca++ influx, Ca++ release and contractile events in the rabbit aorta.

1983 • 39 citations

Demonstration of α1A-and α1B-adrenoceptor binding sites in human brain tissue

1989 • 37 citations

Differences in α₁-adrenoceptor mechanisms for phenylephrine and tizanidine in rabbit thoracic aorta and common iliac artery

1991 • 32 citations

Receptor interactions of imidazolines. II. Affinities and efficacies of hydroxy-substituted tolazoline derivatives in rat aorta.

1979 • 27 citations

Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.

1990 • 25 citations

.ALPHA.1B-Adrenoceptor Mechanisms in Rabbit Iris Dilator.

1992 • 21 citations

Interaction of a chemically reactive prazosin analog with alpha-1 adrenoceptors of rat tissues.

1989 • 21 citations

Interaction of imidazolines with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.

1991 • 18 citations

Newly synthesized α1-adrenoceptor blockers (SM911 and SM2470) and characterization of α-adrenoceptors in rat aortic strips, rat vas deferens preparations and rabbit aortic strips

1985 • 14 citations

A Difference in Receptor Mechanisms for Muscarinic Full and Partial Agonists.

1991 • 12 citations

α1A-Adrenoceptors in rabbit bronchus

1991 • 12 citations

Propylbenzilylcholine Mustard(PrBCM)-Sensitive Cholinoceptors and Contractile Response to Partial Agonist in Guinea Pig Ileal Muscle.

1991 • 9 citations

Effects of Calcium Channel Activators on the Response of Rabbit Aortic Rings to Alpha<sub>1</sub>-Receptor Agonists: Evidence for Two Modes of Action

1989 • 6 citations

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