DISTRIBUTION OF PUTATIVE NEUROTRANSMITTERS IN THE NEOCORTEX

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE

1962 • 2,684 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

The autoradiographic demonstration of axonal connections in the central nervous system

1972 • 1,596 citations

An unidentified depressor substance in certain tissue extracts

1931 • 1,565 citations

The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami

1973 • 1,501 citations

The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine‐B‐hydroxylase as a marker

1975 • 1,454 citations

Topographic atlas of catecholamine and acetylcholinesterase‐containing neurons in the rat brain. I. Forebrain (telencephalon, diencephalon)

1974 • 1,255 citations

Frontiers in Catecholamine Research

1973 • 1,252 citations

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

1976 • 1,247 citations

Muscarinic Cholinergic Binding in Rat Brain

1974 • 1,214 citations

Ascending Monoamine Neurons to the Telencephalon and Diencephalon

1966 • 1,205 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method.

1974 • 1,130 citations

THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS

1967 • 1,116 citations

Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain

1974 • 1,097 citations

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

1977 • 887 citations

Ascending projections of the locus coeruleus in the rat. II. Autoradiographic study

1977 • 835 citations

Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

1978 • 809 citations

Psychopharmacology: A generation of progress

1978 • 785 citations

Isolation of a Sialogogic Peptide from Bovine Hypothalamic Tissue and Its Characterization as Substance P

1970 • 689 citations

The raphe nuclei of the cat brain stem: A topographical atlas of their efferent projections as revealed by autoradiography

1976 • 658 citations

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

1975 • 637 citations

The glyoxylic acid fluorescence histochemical method: a detailed account of the methodology for the visualization of central catecholamine neurons

1974 • 563 citations

Aspinous and sparsely-spinous stellate neurons in the visual cortex of rats contain glutamic acid decarboxylase

1978 • 549 citations

Serotonin nerve terminals in adult rat neocortex

1975 • 504 citations

Mesencephalic dopamine neurons projecting to neocortex

1974 • 503 citations

Dopaminergic Terminals in the Rat Cortex

1973 • 502 citations

A radioautographic study of the efferent pathways of the nucleus locus coeruleus

1974 • 500 citations

Serotonin and lysergic acid diethylamide binding in rat brain membranes: relationship to postsynaptic serotonin receptors.

1976 • 494 citations

A glutamatergic corticostriatal path?

1977 • 487 citations

Magnocellular nuclei of the basal forebrain project to neocortex, brain stem, and olfactory bulb. Review of some functional correlates

1975 • 482 citations

High affinity uptake of glutamate in terminals of corticostriatal axons

1977 • 480 citations

Vasoactive Intestinal Polypeptide: Abundant Immunoreactivity in Neural Cell Lines and Normal Nervous Tissue

1976 • 471 citations

Taurine and Neurological Disorders

1978 • 470 citations

Peptides in Neurobiology

1977 • 450 citations

Acetylcholine released from cerebral cortex in relation to state of activation

1966 • 432 citations

Acetylcholinesterase-rich projections from the basal forebrain of the rhesus monkey to neocortex

1976 • 417 citations

Acetylcholine‐sensitive cells in the cerebral cortex

1963 • 416 citations

Organization of catecholamine neurons projecting to the frontal cortex in the rat

1978 • 415 citations

The amino acid sequence of a hypothalamic peptide, neurotensin.

1975 • 415 citations

Structure of the Porcine Vasoactive Intestinal Octacosapeptide

1974 • 402 citations

Dopaminergic innervation of the rat prefrontal cortex: A fluorescence histochemical study

1976 • 375 citations

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

1972 • 371 citations

Biology of cholinergic function

1977 • 368 citations

The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat.

1948 • 363 citations

Axonal migration of proteins in the central nervous system and peripheral nerves as shown by radioautography

1963 • 354 citations

Calcium-dependent release of somatostatin and neurotensin from rat brain in vitro

1978 • 352 citations

Neurotensin: immunohistochemical localization in rat central nervous system.

1977 • 341 citations

Metabolism of amines in the brain.

1969 • 321 citations

Vasoactive intestinal polypeptide and the nervous system: Immunohistochemical evidence for localization in central and peripheral neurons, particularly intracortical neurons of the cerebral cortex

1977 • 310 citations

BINDING OF [³H]KAINIC ACID, AN ANALOGUE OF <scp>l</scp>‐GLUTAMATE, TO BRAIN MEMBRANES

1976 • 308 citations

Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid

1974 • 306 citations

Aspartate and glutamate as possible transmitters of excitatory hippocampal afferents

1976 • 300 citations

Distribution of noradrenaline nerve terminals in cortical areas of the rat

1968 • 298 citations

Dopamine Nerve Terminals in the Rat Limbic Cortex: Aspects of the Dopamine Hypothesis of Schizophrenia

1974 • 290 citations

The origin and distribution of dopamine-containing afferents to the rat frontal cortex

1978 • 285 citations

The origin of the dopamine nerve terminals in limbic and frontal cortex. Evidence for meso-cortico dopamine neurons

1974 • 284 citations

Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.

1971 • 283 citations

ACTIONS OF CERTAIN AMINES ON CEREBRAL CORTICAL NEURONES

1963 • 280 citations

Histochemical confirmation for dopaminergic innervation of the rat cerebral cortex after destruction of the noradrenergic ascending pathways

1974 • 278 citations

Biochemical mapping of noradrenergic nerves arising from the rat locus coeruleus

1974 • 268 citations

Noradrenaline neuron innervation of the neocortex in the rat

1978 • 265 citations

Impaired Learning and Decreased Cortical Norepinephrine after Bilateral Locus Coeruleus Lesions

1973 • 262 citations

Stimulation and destruction of the locus coeruleus: Opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex

1973 • 258 citations

Cholecystokinin and its COOH-terminal octapeptide in the pig brain.

1977 • 254 citations

Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques

1976 • 251 citations

Converging projections from the mediodorsal thalamic nucleus and mesencephalic dopaminergic neurons to the neocortex in three species

1978 • 250 citations

Localisation of gastrins to neuro- and adenohypophysis

1978 • 243 citations

Glutamic acid as a synaptic transmitter in the nervous system. A review

1972 • 243 citations

Regional and subcellular distributions of brain neurotensin

1976 • 237 citations

DISTRIBUTION OF VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IN THE PORCINE CENTRAL NERVOUS SYSTEM

1978 • 235 citations

Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: Correlations with serotonin levels and histochemical fluorescence

1972 • 232 citations

Projections ascendantes du locus coeruleus et d'autres neurones aminergiques pontiques au niveau du prosencéphale du rat

1972 • 232 citations

Some evidence for the existence of dopaminergic neurons in the rat cortex

1973 • 230 citations

Glutamate as transmitter of hippocampal perforant path

1977 • 227 citations

Evaluation of a radioautographic neuroanatomical tracing method

1968 • 227 citations

Mesencephalic Reticular Activating System and Cortical Acetylcholine Output

1965 • 225 citations

Convergent thalamic and mesencephalic projections to the anterior medial cortex in the rat

1976 • 219 citations

Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy

1977 • 215 citations

Neuropharmacology of Amino Acid Inhibitory Transmitters

1978 • 212 citations

Histamine as a transmitter in brain

1975 • 208 citations

Primary Structure of Somatostatin, A Hypothalamic Peptide That Inhibits the Secretion of Pituitary Growth Hormone

1973 • 203 citations

Subcellular distribution of radioimmunoassayable somatostatin in rat brain

1977 • 202 citations

The release of γ‐aminobutyric acid during inhibition in the cat visual cortex

1971 • 201 citations

Selective Destruction of Neurons by a Transmitter Agonist

1977 • 193 citations

Identification and Distribution of β-Phenylethylamine in the Rat

1973 • 192 citations

Effects of serotonin on central neurons: microiontophoretic administration.

1972 • 190 citations

Fine structure of labelled axons in the cerebellar cortex and nuclei of rodents and primates after intraventricular infusions with tritiated serotonin

1975 • 189 citations

Regional distribution of mast cells containing histamine, dopamine, or 5‐hydroxytryptamine in the mammalian brain

1977 • 189 citations

Neurotransmitter Receptors in the Brain: Biochemical Identification

1976 • 186 citations

H1 and H2 receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices

1975 • 182 citations

Ascending projections of presumed dopamine-containing neurons in the ventral tegmentum of the rat as demonstrated by horseradish peroxidase

1977 • 178 citations

Acetylcholine release from the cerebral cortex: Its role in cortical arousal

1968 • 178 citations

Iontophoresis and transmitter mechanisms in the mammalian central nervous system

1978 • 176 citations

GABA receptor binding with 3H (+) bicuculline–methiodide in rat CNS

1977 • 175 citations

Differential localization of N-acetylated indolealkylamines in CNS and the Harderian gland using immunohistology

1976 • 174 citations

Pharmaco-histochemical evidence of the existence of dopamine nerve terminals in the limbic cortex

1974 • 173 citations

Histaminergic Pathway in Rat Brain Evidenced by Lesions of the Medial Forebrain Bundle

1974 • 171 citations

UPTAKE AND RELEASE OF TAURINE FROM RAT BRAIN SLICES

1972 • 168 citations

Biological Activities of Synthetic Peptides Corresponding to Fragments of and to the Entire Sequence of the Vasoactive Intestinal Peptide

1973 • 167 citations

Vasoactive intestinal polypeptide (VIP): vesicular localization and potassium evoked release from rat hypothalamus

1978 • 166 citations

The mast cells of the mammalian central nervous system

1974 • 162 citations

Modification of the Falck-Hillarp formaldehyde fluorescence method using the vibratome®: simple, rapid and sensitive localization of catecholamines in sections of unfixed or formalin fixed brain tissue

1972 • 158 citations

Neostriatum and functions of prefrontal cortex.

1972 • 157 citations

Classification of monoamine neurones in the rat mesencephalon: Distribution of a new monoamine neurone system

1971 • 154 citations

Identification and Distribution of p-Tyramine in the Rat

1974 • 153 citations

Noradrenergic axon terminals in the cerebral cortex of rat. II. Quantitative data revealed by light and electron microscope radioautography of the frontal cortex

1973 • 147 citations

Histochemical Demonstration of Adrenergic Nerves in Cortex‐Pia of Rabbit

1965 • 146 citations

ENZYMATIC ISOTOPIC ASSAY FOR AND PRESENCE OF β‐PHENYLETHYLAMINE IN BRAIN

1974 • 146 citations

The depression of brain stem neurones by taurine and its interaction with strychnine and bicuculline

1973 • 145 citations

The use of neurotoxic dihydroxytryptamines as tools for morphological studies and localized lesioning of central indolamine neurons

1973 • 145 citations

LOCALIZATION OF GABAERGIC, CHOLINERGIC AND AMINERGIC STRUCTURES IN THE MESOLIMBIC SYSTEM

1977 • 143 citations

Effect of Undercutting on the Acetylcholinesterase and Choline Acetyltransferase Activity in the Cat's Cerebral Cortex

1963 • 142 citations

Human brain substance P: distribution in controls and Huntington's chorea

1978 • 137 citations

An improved histofluorescence procedure for freeze-dried paraffin-embedded tissue based on combined formaldehyde-glyoxylic acid perfusion with high magnesium content and acid pH

1976 • 137 citations

Cholinergic mechanisms in the rat somatosensory cerebral cortex

1972 • 136 citations

Quantitative data on serotonin nerve terminals in adult rat neocortex

1976 • 135 citations

Identification and Distribution of Tryptamine in the Rat

1974 • 135 citations

Adenylate‐Cyclase Receptors for Adrenergic Neurotransmitters in Rat Cerebral Cortex

1973 • 133 citations

Histochemical studies on the distribution of catecholamines and 5-hydroxytryptamine after intraventricular injections

1968 • 132 citations

Choline acetyltransferase localization in the central nervous system by immunohistochemistry

1974 • 132 citations

Catecholamines in the Median Eminence: New Evidence for a Major Noradrenergic Input

1973 • 131 citations

Amino Acids in the Cobalt-Induced Epileptogenic and Nonepileptogenic Cat's Cortex

1972 • 129 citations

Immunohistochemical localization in rabbit brain of a peptide resembling the COOH-terminal octapeptide of cholecystokinin.

1977 • 128 citations

The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat

1976 • 127 citations

Noradrenergic axon terminals in the cerebral cortex of rat. I. Radioautographic visualization after topical application of dl-[3H]norepinephrine

1973 • 126 citations

Dual localization of histamine in an ascending neuronal pathway and in non-neuronal cells evidenced by lesions in the lateral hypothalamic area

1976 • 125 citations

Substance P excitation of cerebral cortical Betz cells

1974 • 125 citations

Central actions of histamine: Microelectrophoretic studies

1977 • 125 citations

DISTRIBUTION AND TURNOVER OF OCTOPAMINE IN TISSUES

1972 • 119 citations

Putative Peptide Neurotransmitters

1977 • 114 citations

Catecholamines in neocortex of rhesus monkeys: regional distribution and ontogenetic development

1977 • 113 citations

CNS at the Cellular Level: Identity of Transmitter Agents

1970 • 113 citations

Specific release of endogenous glutamate from piriform cortex stimulated in vitro

1976 • 112 citations

Amino Acids as Central Neurotransmitters

1975 • 112 citations

Histamine synthesis in the developing rat brain: Evidence for a multiple compartmentation

1975 • 111 citations

DISTRIBUTION OF γ‐AMINOBUTYRIC ACID IN THE LAYERS OF THE CEREBRAL AND CEREBELLAR CORTEX. IMPLICATIONS FOR ITS PHYSIOLOGICAL ROLE*

1962 • 110 citations

The projections of the nucleus locus coeruleus: An autoradiographic study

1973 • 109 citations

A specific and sensitive enzymatic assay for tryptamine in tissues.

1972 • 95 citations

Identification and Distribution of m-Tyramine in the Rat

1975 • 95 citations

Noradrenaline sensitive cells in cat cerebral cortex

1969 • 94 citations

Distribution of Dopamine in the rat cerebral cortex

1976 • 94 citations

Glial uptake of taurine in the rabbit retina

1973 • 93 citations

Antibody to bovine choline acetyltransferase and immunofluorescent localisation of the enzyme in neurones

1974 • 92 citations

Assay by multiple ion detection of phenylethylamine and phenylethanolamine in rat brain

1974 • 89 citations

Silver impregnation of dopaminergic systems after radiofrequency and 6-OHDA lesions of the rat ventral tegmentum

1976 • 89 citations

Differential Labeling of Glial Cells and GABA-inhibitory Interneurons and Nerve Terminals following the Microinjection of [ -3H]Alanine, [3H]DABA and [3H]GABA into Single Folia of the Cerebellum

1976 • 89 citations

Acetylcholinesterase-containing neurons in the neostriatum and substantia nigra revealed after punctate intracerebral injection of di-isopropylfluorophosphate

1975 • 85 citations

Neurochemical and morphological changes during the development of cobalt-induced epilepsy in the rat

1975 • 84 citations

Identification and quantitation of a new indolealkylamine in rat hypothalamus

1973 • 83 citations

Mapping of central noradrenaline pathways with 6-Hydroxy-DOPA

1973 • 83 citations

Synthesis and release of histamine studied on slices from rat hypothalamus

1975 • 78 citations

Enzymatic-isotopic method for octopamine at the picogram level

1974 • 74 citations

The uptake of 5-hydroxytryptamine-3H from the cerebral ventricles: autoradiographic localization

1966 • 72 citations

Demonstration and Distribution of Phenylethanolamine in Brain and Other Tissues

1973 • 71 citations

NORADRENALINE NERVE TERMINALS IN THE CEREBRAL CORTEX: EFFECTS ON NORADRENALINE UPTAKE AND STORAGE FOLLOWING AXONAL LESION WITH 6-HYDROXYDOPAMINE

1974 • 70 citations

Release of amino acids from the maturing cobalt-induced epileptic focus

1976 • 69 citations

Biochemistry and neurology

1977 • 69 citations

Projections to the gyrus proreus from the brain stem tegmentum (locus coeruleus, raphe nuclei) in the cat, demonstrated by retrograde transport of horseradish peroxidase

1975 • 67 citations

Perspectives in Neuropharmacology: A Tribute to Julius Axelrod.

1973 • 66 citations

Detailed noradrenaline pathways of locus coeruleus neuron to the cerebral cortex with use of 6-hydroxydopa

1974 • 65 citations

Immunohistochemical evidence for substance P-containing nerve endings in the human cortex

1976 • 64 citations

Brain levels of tryptamine

1972 • 64 citations

γ-Aminobutyric acid, bicuculline, and post-synaptic binding sites

1973 • 64 citations

Phenethylamines in brain and liver of rats with experimentally induced phenylketonuria-like characteristics

1973 • 63 citations

Centrifugal cholinergic connections in the olfactory system of rats

1977 • 62 citations

OPIOID PEPTIDES

1977 • 61 citations

Demonstration of mast cells in the albino rat brain

1974 • 60 citations

AN ASSAY PROCEDURE FOR TRYPTAMINE IN BRAIN AND SPINAL CORD USING ITS [³H]DANSYL DERIVATIVE

1973 • 58 citations

Immunohistochemical localization of choline acetyltransferase: Real of artefact?

1975 • 57 citations

Evidence for a specific uptake of dopamine by dopaminergic terminals of the rat cerebral cortex

1974 • 55 citations

Microspectrofluorimetric Characterization of Monoamines in the Central Nervous System: Evidence for a New Neuronal Monoamine-like Compound

1971 • 55 citations

Organization of mesencephalic dopamine neurons projecting to neocortex and septum.

1977 • 54 citations

TAURINE IN DEVELOPING RAT BRAIN: SUBCELLULAR DISTRIBUTION AND ASSOCIATION WITH SYNAPTIC VESICLES OF [³⁵S]TAURINE IN MATERNAL, FETAL AND NEONATAL RAT BRAIN

1977 • 51 citations

On the possible existence of a new intraneuronal monoamine in the spinal cord of the rat.

1970 • 51 citations

The normal occurrence of octopamine in the central nervous system of the rat

1977 • 50 citations

A Further Study of the Motoneuron-Depolarizing Peptide Extracted from Dorsal Roots of Bovine Spinal Nerves

1972 • 50 citations

Neurochemical evidence for histamine acting as a transmitter in mammalian brain.

1976 • 50 citations

EFFECTS OF LESIONS AND DRUGS ON BRAIN TRYPTAMINE

1974 • 49 citations

Chemical Transmission and Cortical Arousal

1967 • 47 citations

A dopamine-sensitive adenylate cyclase in anterior limbic cortex and mesolimbic region of primate brain

1975 • 47 citations

[3H]epinephrine and [3H]norepinephrine binding to α-noradrenergic receptors in calf brain membranes

1977 • 40 citations

β-adrenergic receptors in rat cerebral cortex: histochemical localization by a fluorescent β-blocker

1977 • 40 citations

Regional distribution of α-noradrenergic receptor binding in calf brain

1977 • 38 citations

The effect of microelectrophoretically applied mescaline on cortical neurones

1974 • 37 citations

Mast cells in the mammalian area postrema

1972 • 35 citations

The influence of psychotropic drugs on the levels of endogenous 2-phenylethylamine in rabbit brain.

1974 • 35 citations

EFFECTS OF IPRINDOLE ON RESPONSES OF SINGLE CORTICAL AND CAUDATE NEURONES TO MONOAMINES AND ACETYLCHOLINE

1975 • 33 citations

Electrically induced release of [3H]dopamine from slices obtained from different rat brain cortex regions. Evidence for a widespread dopaminergic innervation of the neocortex

1977 • 30 citations

Lesions of the locus ceruleus and noradrenaline metabolism in cerebral cortex

1973 • 29 citations

5-Methoxytryptamine: a possible central nervous system transmitter.

1974 • 29 citations

Molecular Properties of Choline Acetyltransferase and Their Importance for the Compartmentation of Acetylcholine Synthesis

1972 • 28 citations

Amino acid transmitters

2012 • 27 citations

Distribution of Transmitter-Related Enzymes in the Rat Sensorimotor Cortex

1975 • 21 citations

Excitatory Amino Acid Receptors in the Central Nervous System

1975 • 19 citations

Amino Acid Receptors in CNS. II. GABA in Supraspinal Regions

1975 • 19 citations

Identification of the -isomer of tyramine in rat brain

1973 • 18 citations

Intraneuronal indolamines in the central nervous system.

1976 • 15 citations

A histochemical study of catecholamines in the somatosensory area of rat cerebral cortex.

1966 • 14 citations

Choline acetyltransferase and acetylcholinesterase activities in limbic nuclei of the rat brain

1978 • 13 citations

Amine-responsive adenylate cyclase activity from brain: comparisons between rat and rhesus monkey and demonstration of dopamine-stimulated adenylate cyclase in monkey neocortex.

1976 • 8 citations

Some Biochemical Changes in the Isolated Cortex of the Rat

1976 • 5 citations