Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

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Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

1999 • 1,256 citations

Leptin-Replacement Therapy for Lipodystrophy

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Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.

1999 • 891 citations

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

2001 • 728 citations

The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

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Regulation of fatty acid homeostasis in cells: Novel role of leptin

1999 • 442 citations

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

2000 • 439 citations

Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients.

2000 • 435 citations

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2000 • 301 citations

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects

1999 • 298 citations

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1998 • 293 citations

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2000 • 193 citations

Mechanism of troglitazone action in type 2 diabetes.

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Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

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Generalized lipodystrophy: In vivo evidence for hypermetabolism and insulin-resistant lipid, glucose, and amino acid kinetics

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Proton spectroscopy of human stroke: Assessment of transverse relaxation times and partial volume effects in single volume STEAM MRS

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