The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch Signaling

1995 • 1,282 citations

Expression of a Delta homologue in prospective neurons in the chick

1995 • 1,019 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta

1995 • 669 citations

Jagged: A mammalian ligand that activates notch1

1995 • 617 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

Notch is required for successive cell decisions in the developing Drosophila retina.

1989 • 473 citations

Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta

1995 • 458 citations

Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells

1992 • 452 citations

Maintenance of neuroepithelial progenitor cells by Delta–Notch signalling in the embryonic chick retina

1997 • 425 citations

In Vitro Maintenance of Highly Purified, Transplantable Hematopoietic Stem Cells

1997 • 390 citations

Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo

1997 • 380 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila

1991 • 372 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Notch2: a second mammalian Notch gene

1992 • 346 citations

A homolog of Drosophila Notch expressed during mammalian development

1991 • 338 citations

A Chick Homologue ofSerrateand Its Relationship withNotchandDeltaHomologues during Central Neurogenesis

1996 • 323 citations

The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium

1994 • 318 citations

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

1996 • 316 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

Regulation of neuronal diversity in the Xenopus retina by Delta signalling

1997 • 274 citations

Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc

1997 • 261 citations

Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila

1994 • 260 citations

Jagged2: A Serrate-like Gene Expressed during Rat Embryogenesis

1996 • 243 citations

Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells

1996 • 225 citations

Isolation and Functional Analysis of a cDNA for Human Jagged2, a Gene Encoding a Ligand for the Notch1 Receptor

1997 • 192 citations

Characterization and partial purification of a haemopoietic cell growth factor in WEHI-3 cell conditioned medium

1983 • 192 citations

Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo

1995 • 159 citations

Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila

1997 • 156 citations

Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila

1997 • 147 citations

Developmental Signalling: Vertebrate ligands for Notch

1995 • 107 citations

A dominant-negative form of Serrate acts as a general antagonist of Notch activation

1997 • 80 citations

A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

1994 • 16 citations