Rapid Development of Tolerance to Analgesia During Remifentanil Infusion in Humans

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

The Pharmacokinetics of the New Short-acting Opioid Remifentanil (GI87084B) in Healthy Adult Male Volunteers

1993 • 622 citations

Pharmacokinetics of Remifentanil (GI87084B) and Its Major Metabolite (GI90291) in Patients Undergoing Elective Inpatient Surgery

1993 • 452 citations

Measured Context-sensitive Half-times of Remifentanil and Alfentanil

1995 • 400 citations

Remifentanil

1996 • 224 citations

Acute Tolerance in Morphine Analgesia

1991 • 123 citations

Differential development of acute tolerance to analgesia, respiratory depression, gastrointestinal transit and hormone release in a morphine infusion model

1989 • 123 citations

Endocytosis and recycling of G protein-coupled receptors

1997 • 122 citations

Morphine and ibuprofen compared using the cold pressor test

1988 • 121 citations

A Multicenter Evaluation of Remifentanil for Early Postoperative Analgesia

1996 • 89 citations

Demonstration of tolerance and physical dependence in the dog following a short-term infusion of morphine.

1961 • 77 citations

Magnitude of Acute Tolerance to Opioids Is Not Related to Their Potency

1991 • 67 citations

Acute opiate tolerance in man

1981 • 58 citations

Profile of acute tolerance to three sedative anxiolytics

1983 • 56 citations

Pharmacodynamic model for acute tolerance development to the electroencephalographic effects of alfentanil in the rat.

1995 • 53 citations

Time Course Characteristics of Acute Tolerance Development to Continuously Infused Alfentanil in Rats

1996 • 44 citations

Reversal of spinal cord non-opiate analgesia by conditioned anti-analgesia in the rat

1997 • 20 citations

Selective tolerance of group III and IV somatosympathetic reflexes to the effects of alfentanil

1986 • 11 citations