Effects of endothelin-1 on bacterial clearance in rabbits

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart.

1993 • 198 citations

Involvement of endothelin in the regulation of human vascular tonus. Potent vasoconstrictor effect and existence in endothelial cells.

1990 • 119 citations

Acute pro‐inflammatory actions of endothelin‐1 in the guinea‐pig lung: involvement of ET_A and ET_B receptors

1995 • 108 citations

THE RELATIONSHIP BETWEEN THE VASCULAR MANIFESTATIONS OF SHOCK PRODUCED BY ENDOTOXIN, TRAUMA, AND HEMORRHAGE

1957 • 108 citations

THE ROLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN HEMORRHAGIC SHOCK

1959 • 107 citations

Endothelins and pulmonary diseases

1994 • 94 citations

Endothelin-1-induced Bronchoconstriction in Asthma

1997 • 93 citations

Production of transforming growth factor-alpha by normal rat small intestine

1991 • 87 citations

Hypoxia stimulates endothelial cell angiotensin-converting enzyme antigen synthesis

1989 • 79 citations

Endothelin production in sepsis and the adult respiratory distress syndrome

1996 • 68 citations

Circulating endothelin-1 reduces splanchnic and renal blood flow and splanchnic glucose production in humans

1995 • 50 citations

Potent selective vasoconstrictor effects of endothelin in the pig kidney in vivo

1988 • 47 citations

Activated neutrophil by endothelin-1 caused tissue damage in human umbilical cord

1995 • 44 citations

Tissue Expression of Endothelin-1 mRNA in Endotoxaemia

1996 • 42 citations

The two-step conversion of big endothelin 1 to endothelin 1 and degradation of endothelin 1 by subcellular fractions from human polymorphonuclear leukocytes.

1992 • 39 citations

Endothelin-Stimulated Human Monocytes Produce Prostaglandin E2 but Not Leukotriene B4

1993 • 34 citations

Cardiovascular Effects of the Endothelins

1990 • 30 citations

Alterations of bacterial clearance induced by endotoxin and tumor necrosis factor

1993 • 30 citations

Endothelin-1 and thromboxane A2 increase pulmonary vascular resistance in granulocyte-mediated lung injury

1998 • 29 citations

Effects of Hemorrhage on Inflammatory Response

1984 • 27 citations

Effect of volume support, antibiotic therapy, and monoclonal antiendotoxin antibodies on mortality rate and blood concentrations of endothelin and other mediators in fulminant intra-abdominal sepsis in rats

1995 • 24 citations

Effects of hemorrhage, hypoxia, and intravascular coagulation on bacterial clearance and translocation

1993 • 21 citations

Stimulation of mitogenesis in human thyroid epithelial cells by endothelin

1993 • 20 citations

Sublethal Hemorrhage Impairs the Acute Peritoneal Inflammatory Response in the Rat

1985 • 18 citations

Endothelin Immunoreactivity in Mice with Gram-Negative Bacteraemia: Relationship to Tumour Necrosis Factor-α

1990 • 17 citations

Endothelin produces systemic vasodilation independent of the state of consciousness

1989 • 12 citations