Regulation of isocitrate dehydrogenase by phosphorylation involves no long-range conformational change in the free enzyme.

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

PROTEIN SERINE/THREONINE KINASES

1987 • 1,457 citations

Traitement statistique des erreurs dans la determination des structures cristallines

1952 • 1,284 citations

Interactive computer graphics: FRODO

1985 • 848 citations

The role and control of the glyoxylate cycle in Escherichia coli

1966 • 594 citations

Structural changes in glycogen phosphorylase induced by phosphorylation

1988 • 302 citations

Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate.

1987 • 300 citations

Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase.

1989 • 205 citations

Phosphorylation of isocitrate dehydrogenase as a demonstration of enhanced sensitivity in covalent regulation

1983 • 192 citations

The branch point effect. Ultrasensitivity and subsensitivity to metabolic control.

1984 • 181 citations

Purification and properties of phosphorylated isocitrate dehydrogenase of Escherichia coli.

1979 • 160 citations

Synthesis of C4-dicarboxylic acids from acetate by a “glyoxylate bypass” of the tricarboxylic acid cycle

1957 • 148 citations

Evidence for protein kinase activities in the prokaryote Salmonella typhimurium

1978 • 114 citations

Regulation of Isocitrate Dehydrogenase Activity in Escherichia coli on Adaptation to Acetate

1971 • 110 citations

Phosphorylation Inactivates Escherichia coli Isocitrate Dehydrogenase by Preventing Isocitrate Binding

1989 • 73 citations

The phosphorylation of Escherichia coli isocitrate dehydrogenase in intact cells

1984 • 67 citations

The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium

1982 • 40 citations