Antiangiogenic agents

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types.

1999 • 1,044 citations

Reduced angiogenesis and tumor progression in gelatinase A-deficient mice.

1998 • 887 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

Endostatin Induces Endothelial Cell Apoptosis

1999 • 594 citations

Angiostatin binds ATP synthase on the surface of human endothelial cells

1999 • 520 citations

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

1998 • 477 citations

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

1998 • 431 citations

Kringle Domains of Human Angiostatin

1996 • 366 citations

Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

1999 • 332 citations

Matrix metalloproteinases

1998 • 267 citations

Manipulating Angiogenesis

1997 • 260 citations

Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials

1999 • 234 citations

Preclinical Safety Evaluation of rhuMAbVEGF, an Antiangiogenic Humanized Monoclonal Antibody

1999 • 198 citations

Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor.

1993 • 108 citations

Efficacy and Concentration-Response of Murine Anti-VEGF Monoclonal Antibody in Tumor-Bearing Mice and Extrapolation to Humans

1999 • 80 citations

Molecular mechanisms of tumor metastasis and angiogenesis

1999 • 77 citations

Small Molecule Inhibitors of Tumor-Promoted Angiogenesis, Including Protein Tyrosine Kinase Inhibitors

1999 • 67 citations

Angiostatic activity of synthetic inhibitors of urokinase type plasminogen activator.

1999 • 51 citations

Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody

1999 • 49 citations

Angiostatin inhibits endothelial and melanoma cellular invasion by blocking matrix-enhanced plasminogen activation

1999 • 45 citations

A novel animal model for hemangiomas: inhibition of hemangioma development by the angiogenesis inhibitor TNP-470.

1999 • 40 citations

Emerging therapeutic targets in angiogenesis

1998 • 1 citations

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