Wild-Type V(D)J Recombination in scid Pre-B Cells

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

DNA cloning : a practical approach

1985 • 2,302 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

Preparative and analytical purification of DNA from agarose.

1979 • 1,585 citations

The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition

1986 • 772 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency

1986 • 558 citations

V(D)J recombination: a functional definition of the joining signals.

1989 • 467 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription

1989 • 432 citations

Evidence of functional lymphocytes in some (leaky) scid mice.

1988 • 347 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

Functional status of cells from lymphoid and myeloid tissues in mice with severe combined immunodeficiency disease.

1984 • 229 citations

Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains.

1987 • 187 citations

Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts

1988 • 177 citations

Novel strand exchanges in V(D)J recombination

1988 • 174 citations

Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

1988 • 174 citations

DNA Elements Are Asymmetrically Joined During the Site-Specific Recombination of Kappa Immunoglobulin Genes

1985 • 152 citations

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

1989 • 128 citations

Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector.

1987 • 125 citations

Joining of VK to JK gene segments in a retroviral vector introduced into lymphoid cells

1984 • 110 citations

Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus.

1989 • 97 citations

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.

1988 • 94 citations

Inducible transcription of the unrearranged kappa constant region locus is a common feature of pre-B cells and does not require DNA or protein synthesis.

1985 • 79 citations

Aberrant immunoglobulin gene rearrangement in scid mouse bone marrow cells.

1988 • 65 citations

Unusual Immunoglobulin Gene Rearrangement Leads to Replacement of Recombinational Signal Sequences

1988 • 61 citations

Abnormal recombination of Igh D and J gene segments in transformed pre-B cells of scid mice.

1988 • 55 citations

Detection and characterization of functional T cells in mice with severe combined immune deficiency

1988 • 52 citations

Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.

1990 • 49 citations

T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.

1990 • 46 citations