Control of Adenovirus Late Promoter Expression in Two Human Cell Lines

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Expression of a β-globin gene is enhanced by remote SV40 DNA sequences

1981 • 1,677 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene

1982 • 1,406 citations

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982 • 1,371 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

In vivo sequence requirements of the SV40 early promoter region

1981 • 1,156 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Promoter Sequences of Eukaryotic Protein-Coding Genes

1980 • 971 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Spliced early mRNAs of simian virus 40

1978 • 817 citations

An adenovirus type 5 early gene function regulates expression of other early viral genes.

1979 • 791 citations

Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II

1983 • 779 citations

The SV40 72 base repair repeat has a striking effect on gene expression both in SV40 and other chimeric recombinants

1981 • 776 citations

Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs

1979 • 756 citations

DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo

1983 • 692 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Host-specific activation of transcription by tandem repeats from simian virus 40 and Moloney murine sarcoma virus.

1982 • 625 citations

Simian Virus 40 Deoxyribonucleic Acid Synthesis: the Viral Replicon

1972 • 609 citations

Mechanism of activation of early viral transcription by the adenovirus E1A gene product

1981 • 604 citations

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 • 586 citations

Enhancer elements

1983 • 576 citations

The adenovirus type 5 E1A transcriptional control region contains a duplicated enhancer element

1983 • 467 citations

Simian virus 40 tandem repeated sequences as an element of the early promoter.

1981 • 462 citations

Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription

1984 • 458 citations

Regulation of tumor antigen synthesis by simain virus 40 gene A

1975 • 435 citations

Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue

1978 • 408 citations

Coincidence of the promoter and capped 5′ terminus of RNA from the adenovirus 2 major late transcription unit

1978 • 390 citations

Specific interaction between enhancer-containing molecules and cellular components

1984 • 374 citations

Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

1983 • 373 citations

Adenovirus E1a proteins repress transcription from the SV40 early promoter

1985 • 366 citations

Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site

1982 • 353 citations

A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairs

1981 • 339 citations

Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin

1984 • 329 citations

Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication

1984 • 292 citations

cis and trans activation of globin gene transcription in transient assays.

1983 • 257 citations

Activation of gene expression by adenovirus and herpesvirus regulatory genes acting in trans and by a cis-acting adenovirus enhancer element

1983 • 250 citations

Expression of early adenovirus genes requires a viral encoded acidic polypeptide.

1981 • 237 citations

Regulated expression of human growth hormone genes in mouse cells

1982 • 219 citations

DNA sequence required for initiation of transcription in vitro from the major late promoter of adenovirus 2.

1981 • 216 citations

Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen.

1984 • 207 citations

Control of adenovirus early gene expression: A class of immediate early products

1980 • 182 citations

Sequences upstream from the T-A-T-A box are required in vivo and in vitro for efficient transcription from the adenovirus serotype 2 major late promoter.

1982 • 178 citations

Adenovirus 5 DNA sequences present and RNA sequences transcribed in transformed human embryo kidney cells (HEK-Ad-5 or 293)

1979 • 176 citations

SV40 T antigen binding site mutations that affect autoregulation

1983 • 145 citations

Viral DNA Synthesis in Cells Infected by Temperature-Sensitive Mutants of Simian Virus 40

1974 • 144 citations

Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional level.

1984 • 138 citations

Characterization of the immediate-early functions of pseudorabies virus

1983 • 135 citations

An enhancer element is located 340 base pairs upstream from the adenovirus-2 E1A capsite

1983 • 116 citations

Stimulation ofin vitrotranscription by the upstream element of the adenovirus-2 major late promoter involves a specific factor

1984 • 113 citations

In vitro transcription from the adenovirus 2 major late promoter utilizing templates truncated at promoter-proximal sites.

1984 • 90 citations

The E4 transcilpilonal unit of Ad2: far upstream sequences are required for its transactivation by E1A

1984 • 86 citations

Enhancers and eukaryotic gene expression

1984 • 83 citations

Bovine Papilloma Virus Contains an Activator of Gene Expression at the Distal End of the Early Transcription Unit

1983 • 77 citations

Generation and functional analyses for base-substitution mutants of the adenovirus 2 major late promoter

1984 • 64 citations

S1 sensitive sites in adenovirus DNA

1983 • 56 citations

Analysis of the Expression of Genes Encoding Animal mRNA by in Vitro Techniques

1983 • 50 citations

Regulation of Transcription of the Adenovirus EII Promoter by EIa Gene Products: Absence of Sequence Specificity

1984 • 50 citations

DNA sequences affecting specific initiation of transcription in vitro from the EIII promoter of adenovirus 2.

1982 • 46 citations

Functional analysis of the nucleotide sequence surrounding the cap site for adenovirus type 5 region E1A messenger RNAs

1983 • 39 citations

RNA Sequence Containing Hexanucleotide AAUAAA Directs Efficient mRNA Polyadenylation In Vitro

1985 • 35 citations

Localization of Active Promoters for Eucaryotic RNA Polymerase II in the Long Terminal Repeat of Avian Sarcoma Virus DNA

1983 • 17 citations