Postoperative Epidural Opioid Analgesia

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Epidural Anesthesia and Analgesia

1995 • 1,142 citations

Protein kinase C reduces Mg2+ block of NMDA-receptor channels as a mechanism of modulation

1992 • 962 citations

Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives

1983 • 375 citations

Rostral Spread of Epidural Morphine

1982 • 342 citations

The NMDA Receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids

1994 • 279 citations

Statistical analysis of drug combinations for synergism

1992 • 235 citations

Fentanyl Blood Concentration-Analgesic Response Relationship in the Treatment of Postoperative Pain

1988 • 230 citations

A Randomized Double-blind Comparison of Epidural versus Intravenous Fentanyl Infusion for Analgesia after Thoracotomy

1991 • 226 citations

Postoperative Epidural Morphine Is Safe on Surgical Wards

1991 • 215 citations

The development of morphine tolerance and dependence is associated with translocation of protein kinase C

1995 • 212 citations

Continuous Infusion Epidural Analgesia during Labor

1988 • 210 citations

Antinociceptive Synergy Between Intrathecal Morphine and Lidocaine during Visceral and Somatic Nociception in the Rat

1992 • 204 citations

Epidural and Intravenous Fentanyl Infusions Are Clinically Equivalent After Knee Surgery

1990 • 204 citations

A Randomized Comparison of Intravenous Versus Lumbar and Thoracic Epidural Fentanyl for Analgesia after Thoracotomy

1992 • 203 citations

Differential Analgesic Effects of Low-Dose Epidural Morphine and Morphine-Bupivacaine at Rest and During Mobilization After Major Abdominal Surgery

1992 • 197 citations

Use of Patient-Controlled Analgesia to Compare the Efficacy of Epidural to Intravenous Fentanyl Administration

1992 • 197 citations

Pharmacokinetics of fentanyl in lumbar and cervical CSF following lumbar epidural and intravenous administration

1989 • 195 citations

Postoperative Epidural Bupivacaine-Morphine Therapy Experience with 4,227 Surgical Cancer Patients

1994 • 167 citations

Interaction of Intrathecal Morphine with Bupivacaine and Lidocaine in the Rat

1992 • 166 citations

Specific Enhancement by Fentanyl of the Effects of Intrathecal Bupivacaine on Nociceptive Afferent But Not on Sympathetic Efferent Pathways in Dogs

1993 • 164 citations

Physical and Chemical Properties of Drug Molecules Governing their Diffusion Through the Spinal Meninges

1992 • 157 citations

Role of Spinal Opioid Receptors in the Antinociceptive Interactions Between Intrathecal Morphine and Bupivacaine

1992 • 156 citations

Mechanisms of the analgesic actions of opiates and opioids

1991 • 148 citations

A Randomized Double-Blind Comparison of Epidural Versus Intravenous Fentanyl Infusion for Analgesia after Cesarean Section

1990 • 143 citations

A Controlled Study on the Effect of Epidural Analgesia with Local Anaesthetics and Morphine on Morbidity after Abdominal Surgery

1985 • 142 citations

A Randomized, Double-blind Comparison of Lumbar Epidural and Intravenous Fentanyl Infusions for Postthoracotomy Pain Relief

1992 • 140 citations

Patient-controlled Analgesic Therapy, Part II

1982 • 124 citations

Opioid receptor reserve in normal and morphine-tolerant guinea pig ileum myenteric plexus.

1984 • 121 citations

Solubility and related physicochemical properties of narcotic analgesics.

1988 • 114 citations

Cephalad migration of morphine in CSF following lumbar epidural administration in patients with cancer pain

1985 • 108 citations

Pharmacology of Epidural Fentanyl, Alfentanil, and Sufentanil in Volunteers

1994 • 105 citations

Morphine and Hydromorphone Epidural Analgesia

1992 • 98 citations

Epidural Bupivacaine/Sufentanil Therapy for Postoperative Pain Control in Patients Tolerant to Opioid and Unresponsive to Epidural Bupivacaine/Morphine

1994 • 91 citations

COMPARISON OF FOUR NARCOTIC ANALGESICS FOR EXTRADURAL ANALGESIA

1982 • 89 citations

The Medullary Dorsal Horn

1993 • 88 citations

A Randomized Double-Blind Comparison of Epidural Sufentanil Versus Intravenous Sufentanil or Epidural Fentanyl Analgesia After Major Abdominal Surgery

1993 • 88 citations

Patient-controlled lumbar epidural fentanyl compared with patient-controlled intravenous fentanyl for post-thoracotomy pain

1992 • 84 citations

Intravenous Versus Epidural Administration of Hydromorphone

1995 • 77 citations

CSF and blood pharmacokinetics of hydromorphone and morphine following lumbar epidural administration

1991 • 76 citations

Low-Dose Bupivacaine Does Not Improve Postoperative Epidural Fentanyl Analgesia in Orthopedic Patients

1991 • 75 citations

Alfentanil Infusion for Postoperative Pain

1991 • 74 citations

Spinal local anaesthetic actions on afferent evoked responses and wind-up of nociceptive neurones in the rat spinal cord: combination with morphine produces marked potentiation of antinociception

1992 • 74 citations

A Prospective, Randomized, Double-blind Comparison of Epidural and Intravenous Sufentanil Infusions

1994 • 74 citations

Patient-controlled on-demand epidural fentanyl.

1991 • 72 citations

Bupivacaine 0.1% does not improve postoperative epidural fentanyl analgesia after abdominal or thoracic surgery

1992 • 65 citations

Morphine-induced opioid receptor down-regulation detected in intact adult rat brain cells

1986 • 62 citations

Reduction in opiate receptor reserve in morphine tolerant guinea pig ilea

1982 • 53 citations

Equivalence of Postoperative Analgesia with Patient-Controlled Intravenous or Epidural Alfentanil

1993 • 52 citations

A Comparison of Patient Controlled Epidural Analgesia with Sufentanil by the Lumbar Versus Thoracic Route After Thoracotomy

1994 • 49 citations

Computer-controlled Infusion of Alfentanil for Postoperative Analgesia

1993 • 49 citations

Epidural Sufentanil for Acute Pain Control in a Patient with Extreme Opioid Dependency

1992 • 43 citations

CLINICAL ASSESSMENT AND PLASMA PHARMACOKINETICS ASSOCIATED WITH INTRAMUSCULAR OR EXTRADURAL ALFENTANIL

1985 • 35 citations

The practice of medicine in the year 2010

1993 • 19 citations

Pharmacokinetics of Alfentanil after Epidural Administration

1994 • 16 citations

Subdural Block during Attempted Caudal Epidural Analgesia for Labor

1992 • 4 citations