Hemoglobin-Based Red Blood Cell Substitutes

Semipermeable Microcapsules

1964 • 983 citations

Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin

1998 • 427 citations

SEMIPERMEABLE AQUEOUS MICROCAPSULES: I. PREPARATION AND PROPERTIES

1966 • 342 citations

The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery

1998 • 334 citations

Therapeutic applications of polymeric artificial cells

2005 • 306 citations

Expression of fully functional tetrameric human hemoglobin in Escherichia coli.

1990 • 234 citations

The Life-Sustaining Capacity of Human Polymerized Hemoglobin When Red Cells Might Be Unavailable

2002 • 219 citations

Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties

1998 • 208 citations

Current status of blood substitute research: towards a new paradigm

2003 • 207 citations

Stablisation of enzymes by microencapsulation with a concentrated protein solution or by microencapsulation followed by cross-linking with glutaraldehyde

1971 • 176 citations

The Use of Bovine Hemoglobin Glutamer-250 (Hemopure®) in Surgical Patients: Results of a Multicenter, Randomized, Single-Blinded Trial

2002 • 174 citations

The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution

2000 • 135 citations

Transfusions of Polymerized Bovine Hemoglobin in a Patient with Severe Autoimmune Hemolytic Anemia

2000 • 122 citations

Future generations of red blood cell substitutes

2003 • 104 citations

Analysis of Polyethylene‐glycol‐polylactide Nano‐Dimension Artificial Red Blood Cells in Maintaining Systemic Hemoglobin Levels and Prevention of Methemoglobin Formation

2003 • 78 citations

Submicron Polymer Membrane Hemoglobin Nanocapsules as Potential Blood Substitutes: Preparation and Characterization

1996 • 77 citations

Red blood cell substitutes

2000 • 70 citations

Crosslinked Hemoglobin-Superoxide Dismutase-Catalase Scavenges Free Radicals in a Rat Model of Intestinal Ischemia-Reperfusion Injury

1997 • 50 citations

Submicron Biodegradable Polymer Membrane Hemoglobin Nanocapsules as Potential Blood Substitutes: A Preliminary Report

1994 • 45 citations

Absence of Hemoprotein-Associated Free Radical Events Following Oxidant Challenge of Crosslinked Hemoglobin–Superoxide Dismutase Catalase

1998 • 42 citations

Nitric oxide scavengers in the treatment of shock associated with systemic inflammatory response syndrome

1999 • 38 citations

Artificial Cell Bioencapsulation in Macro, Micro, Nano, and Molecular Dimensions: Keynote Lecture

2004 • 21 citations

Bioartificial Organs: Risks and Requirements

1999 • 9 citations