Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression.

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase

1988 • 4,259 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

1987 • 924 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Mechanism of glucose-induced insulin secretion.

1980 • 425 citations

Functional antagonism between c-Jun and MyoD proteins: A direct physical association

1992 • 424 citations

Glucoreceptor mechanisms and the control of insulin release and biosynthesis

1980 • 280 citations

Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression.

1992 • 250 citations

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures.

1990 • 174 citations

Definition of the carbohydrate response element of the rat S14 gene. Evidence for a common factor required for carbohydrate regulation of hepatic genes.

1992 • 165 citations

INSULIN BIOSYNTHESIS IN THE RAT: DEMONSTRATION OF TWO PROINSULINS

1969 • 155 citations

Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin Enhancer

1991 • 150 citations

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

1991 • 130 citations

c-Jun represses the human insulin promoter activity that depends on multiple cAMP response elements.

1992 • 109 citations

Control of insulin gene expression by glucose

1992 • 82 citations

Mutagenesis of the Rat Insulin II 5′-Flanking Region Defines Sequences Important for Expression in HIT Cells

1989 • 49 citations

Pancreatic β-Cell-Type-Specific Transcription of the Insulin Gene Is Mediated by Basic Helix-Loop-Helix DNA-Binding Proteins

1991 • 37 citations

c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control.

1994 • 37 citations

How are the regulators regulated?

1991 • 35 citations

Structure and Evolution of the Insulin Gene

1985 • 24 citations

A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer

1990 • 3 citations

Genetics Of Early Neurogenesis In Drosophila Melanogaster

1990 • 2 citations