G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

Accumulation of Nuclear p53 and Tumor Progression in Bladder Cancer

1994 • 828 citations

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1996 • 806 citations

Nuclear Overexpression of p53 Protein in Transitional Cell Bladder Carcinoma: A Marker for Disease Progression

1993 • 544 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

Growth suppression by p16ink4 requires functional retinoblastoma protein.

1995 • 441 citations

Cyclin D1 Is Dispensable for G₁ Control in Retinoblastoma Gene-Deficient Cells Independently of cdk4 Activity

1995 • 370 citations

Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer.

1993 • 367 citations

Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

1995 • 355 citations

Altered Expression of the Retinoblastoma Gene Product: Prognostic Indicator in Bladder Cancer

1992 • 348 citations

Cyclin D1 and prognosis in human breast cancer

1996 • 318 citations

Over‐expression of p53 nuclear oncoprotein in transitional‐cell bladder cancer and its prognostic value

1993 • 264 citations

Altered Expression of Retinoblastoma Protein and Known Prognostic Variables in Locally Advanced Bladder Cancer

1992 • 254 citations

p53 mutations in human bladder cancer: Genotypicversus phenotypic patterns

1994 • 250 citations

Deletion of the p16 and p15 Genes in Human Bladder Tumors

1995 • 185 citations

p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer

1995 • 178 citations

Unrestricted cell cycling and cancer

1995 • 164 citations

Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancer.

1994 • 156 citations

Expression of Epidermal Growth Factor Receptor in Invasive Transitional Cell Carcinoma of the Urinary Bladder:A Multivariate Survival Analysis

1994 • 133 citations

Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study

1996 • 128 citations

Immunohistochemical Analysis of the p16INK4 Cyclin-Dependent Kinase Inhibitor in Malignant Mesothelioma

1995 • 127 citations

Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features

1997 • 104 citations

Aberrations of p16^Ink4 and retinoblastoma tumour‐suppressor genes occur in distinct sub‐sets of human cancer cell lines

1995 • 102 citations

Prevalence and Clinical Significance of Her-2/neu, p53 and Rb Expression in Primary Superficial Bladder Cancer

1996 • 90 citations

Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

1997 • 83 citations

Relationship of p53 and bcl-2 to Prognosis in Muscle-Invasive Transitional Cell Carcinoma of the Bladder

1996 • 60 citations

p53 and Rb Immunostaining in Locally Advanced Bladder Cancer: Relation to Prognostic Variables and Predictive Value for the Local Response to Radical Radiotherapy

1995 • 50 citations

Reduced expression of retinoblastoma (Rb) gene protein is related to cell proliferation and prognosis in transitional-cell bladder cancer

1995 • 38 citations

Homozygous deletions but no sequence mutations in coding regions of p15 or p16 in human primary bladder tumors

1995 • 34 citations

p16 INK4 Mutations and Altered Expression in Human Tumors and Cell Lines

1994 • 32 citations