Pharmacogenetics

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1998 • 820 citations

Identification of genetic polymorphisms at the glutathione S- transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer

1997 • 749 citations

The clinical pharmacology of 6-mercaptopurine

1992 • 640 citations

Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies

1999 • 626 citations

DRUG REACTIONS, ENZYMES, AND BIOCHEMICAL GENETICS

1957 • 437 citations

Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease

1992 • 414 citations

Nomenclature for human CYP2D6 alleles

1996 • 406 citations

Moderne Probleme der Humangenetik

1959 • 391 citations

Molecular mechanism of slow acetylation of drugs and carcinogens in humans.

1991 • 355 citations

Genetic association between sensitivity to warfarin and expression of CYP2C9*3

1997 • 309 citations

Genetic analysis of the human cytochrome P450 CYP2C9 locus

1996 • 300 citations

Genetic polymorphism of S-mephenytoin hydroxylation

1989 • 292 citations

Molecular mechanisms of drug resistance

1990 • 279 citations

Association of cytochrome P450 1B1 (CYP1B1) polymorphism with steroid receptor status in breast cancer.

1998 • 218 citations

Genetic and environmental factors affecting ethanol metabolism in man

1971 • 207 citations

4. TOXICITY OF PRIMAQUINE IN NEGROES

1952 • 138 citations

BIOCHEMICAL INDIVIDUALITY

1957 • 118 citations

Phenotypic differences in mephenytoin pharmacokinetics in normal subjects.

1985 • 96 citations

Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation

1986 • 87 citations

Pharmacogenetics of aldehyde dehydrogenase (ALDH)

1990 • 74 citations

Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients.

1988 • 42 citations

Molecular Genetics of Drug Resistance

2024 • 29 citations

Inborn Errors of Metabolism

2012 • 17 citations

The Pharmacologic Principles of Medical Practice

1953 • 15 citations

Individual and ethnic differences in ethanol elimination.

1987 • 12 citations

The Molecular Biology Of G6PD Variants And Other Red Cell Enzyme Defects

1992 • 11 citations

Drug interactions with grapefruit juice

1998 • 5 citations