Sequence and Regulation of a Gene Encoding a Human 89-Kilodalton Heat Shock Protein

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression

1987 • 2,333 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis

1986 • 524 citations

The nucleotide sequence of the human β-globin gene

1980 • 502 citations

Germline Transformation Used to Define Key Features of Heat-Shock Response Elements

1988 • 451 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins.

1983 • 431 citations

Purification of the major mammalian heat shock proteins.

1982 • 369 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins.

1986 • 338 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

Sequence and organization of genes encoding the human 27 kDa heat shock protein

1986 • 299 citations

A mouse tumor-specific transplantation antigen is a heat shock-related protein.

1986 • 295 citations

Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions

1980 • 286 citations

Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells

1983 • 278 citations

Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

1987 • 267 citations

Structure and expression of a human gene coding for a 71 kd heat shock ‘cognate’ protein

1987 • 254 citations

A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock protein.

1981 • 246 citations

Transcription of the human hsp70 gene is induced by serum stimulation.

1985 • 235 citations

[66] Mapping of gene transcripts by nuclease protection assays and cDNA primer extension

1987 • 228 citations

The dynamic state of heat shock proteins in chicken embryo fibroblasts.

1986 • 227 citations

Interspecific nucleotide sequence comparisons used to identify regulatory and structural features of the Drosophila hsp82 gene

1986 • 223 citations

Regulation of Human Histone Gene Expression: Kinetics of Accumulation and Changes in the Rate of Synthesis and in the Half-Lives of Individual Histone mRNAs During the HeLa Cell Cycle

1983 • 218 citations

Eukaryotic Mr 83,000 heat shock protein has a homologue in Escherichia coli.

1987 • 211 citations

Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells.

1987 • 193 citations

Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphorylated in vitro by casein kinase II

1989 • 190 citations

Complete sequence of the heat shock-inducible HSP90 gene of Saccharomyces cerevisiae.

1984 • 189 citations

Transformation of glucocorticoid and progesterone receptors to the DNA‐binding state

1987 • 187 citations

Nucleotide sequence of a cDNA for a member of the human 90-kDa heat-shock protein family

1987 • 176 citations

[8] Electrophoresis in agarose and acrylamide gels

1987 • 175 citations

Heat shock but not other stress inducers leads to the disruption of a sub-set of snRNPs and inhibition of in vitro splicing in HeLa cells.

1988 • 168 citations

Calmodulin-regulated binding of the 90-kDa heat shock protein to actin filaments.

1986 • 165 citations

Modulation of heat shock polypeptide synthesis in HeLa cells during hyperthermia and recovery

1982 • 162 citations

Xenopus hsp 70 genes are constitutively expressed in injected oocytes.

1984 • 159 citations

Steroid hormone antagonists at the receptor level: A role for the heat‐shock protein MW 90,000 (hsp 90)

1987 • 143 citations

Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts.

1985 • 143 citations

The 90-kilodalton peptide of the heme-regulated eIF-2.alpha. kinase has sequence homology with the 90-kilodalton heat shock protein

1987 • 130 citations

Molecular cloning of sequences encoding the human heat-shock proteins and their expression during hyperthermia

1986 • 129 citations

The Genome of Trypanosoma cruzi Contains a Constitutively Expressed, Tandemly Arranged Multicopy Gene Homologous to a Major Heat Shock Protein

1987 • 129 citations

Selective Induction of Human Heat Shock Gene Transcription by the Adenovirus E1A Gene Products, Including the 12S E1A Product

1987 • 123 citations

Evidence that the 90-Kilodalton Heat Shock Protein is Associated with Tubulin-Containing Complexes in L Cell Cytosol and in Intact PtK Cells

1988 • 122 citations

Molecular cloning and analysis of DNA complementary to three mouse Mr = 68,000 heat shock protein mRNAs.

1986 • 116 citations

Locus Encoding a Family of Small Heat Shock Genes in Caenorhabditis elegans: Two Genes Duplicated to Form a 3.8-Kilobase Inverted Repeat

1985 • 110 citations

Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products

1986 • 110 citations

Conserved Sequences and Transcription of the hsp70 Gene Family in Trypanosoma brucei

1986 • 108 citations

Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein.

1987 • 102 citations

Cloning and nucleotide sequence of the murine hsp84 cDNA and chromosome assignment of related sequences

1987 • 97 citations

Mitogen activation induces the enhanced synthesis of two heat-shock proteins in human lymphocytes.

1988 • 80 citations

Posttranscriptional Regulation of hsp70 Expression in Human Cells: Effects of Heat Shock, Inhibition of Protein Synthesis, and Adenovirus Infection on Translation and mRNA Stability

1987 • 77 citations

Effect of heat shock on RNA metabolism in HeLa cells

1988 • 76 citations

Quantitation and Intracellular Localization of the 85K Heat Shock Protein by Using Monoclonal and Polyclonal Antibodies

1984 • 67 citations

A DNA sequence analysis package for the IBM personal computer

1984 • 63 citations

DNA sequence analysis on the IBM-PC

1984 • 61 citations

Estrogenic Regulation of Uterine 90-Kilodalton Heat Shock Protein *

1988 • 58 citations

Expression of intron-containingC. elegansheat shock genes in mouse cells demonstrates divergence of 3' splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus

1987 • 54 citations

Altered Expression of Heat Shock Proteins in Embryonal Carcinoma and Mouse Early Embryonic Cells

1984 • 48 citations

Metabolite regulation of heat shock protein levels.

1983 • 45 citations

Mouse and Drosophila Genes Encoding the Major Heat Shock Protein (hsp70) Are Highly Conserved

1983 • 39 citations

Association of the Transforming Proteins of Rous, Fujinami, and Y73 Avian Sarcoma Viruses with the Same Two Cellular Proteins

1982 • 37 citations

Translational activation of maternal mRNA encoding the heat-shock protein hsp90 during sea urchin embryogenesis

1986 • 35 citations

Cellular localization of Drosophila 83-kilodalton heat shock protein in normal, heat-shocked, and recovering cultured cells with a specific antibody

1986 • 32 citations

Molecular cloning of a steroid-regulated 108K beat shock protein gene from hen oviduct

1986 • 26 citations

Sequence analysis of the nonsteroid binding component of the calf uterine estrogen receptor

1988 • 22 citations

Effect of the 90 kDa heat shock protein, HSP90, on glucocorticoid receptor binding to DNA-cellulose

1988 • 22 citations

Purification and characterization of a major component from the cytoplasmic matrix of cultured murine L cells

1979 • 18 citations

Chapter 21. Isolation of Histone Messenger RNA and Its Translationin Vitro

1978 • 9 citations