Developmental Regulation of α-Fetoprotein Genes in Transgenic Mice

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

1980 • 8,711 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes

1983 • 1,449 citations

Genetic transformation of mouse embryos by microinjection of purified DNA.

1980 • 1,428 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

1982 • 1,338 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Immunoglobulin gene transcription is activated by downstream sequence elements

1983 • 830 citations

Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs

1981 • 681 citations

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

1983 • 659 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

Introduction of a rabbit β-globin gene into the mouse germ line

1981 • 458 citations

Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring

1982 • 379 citations

Transcriptional control of the murine albumin/alpha-fetoprotein locus during development.

1982 • 371 citations

Chromosomal position and activation of retroviral genomes inserted into the germ line of mice

1981 • 344 citations

Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes.

1984 • 305 citations

Introduction of a μ immunoglobulin gene into the mouse germ line: Specific expression in lymphoid cells and synthesis of functional antibody

1984 • 304 citations

α-Fetoprotein in Cancer and Fetal Development

1979 • 299 citations

The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.

1981 • 285 citations

Polyadenylic acid-containing RNA in Xenopus laevis oocytes

1974 • 259 citations

A foreign β-globin gene in transgenic mice: Integration at abnormal chromosomal positions and expression in inappropriate tissues

1983 • 245 citations

Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice

1984 • 239 citations

The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.

1981 • 206 citations

Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

1983 • 202 citations

Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene

1984 • 187 citations

Structure of two related rat pancreatic trypsin genes.

1984 • 177 citations

Transmission distortion and mosaicism in an unusual transgenic mouse pedigree

1984 • 169 citations

Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line

1983 • 161 citations

The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.

1981 • 151 citations

Genetic control of alpha-fetoprotein synthesis in the mouse.

1977 • 135 citations

Increase in level of functional messenger RNA coding for phosphoenolpyruvate carboxykinase (GTP) during induction by cyclic adenosine 3':5'-monophosphate.

1977 • 133 citations

alpha-Fetoprotein and albumin genes are in tandem in the mouse genome.

1981 • 127 citations

Expression of the chicken transferrin gene in transgenic mice

1983 • 126 citations

Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation

1980 • 121 citations

Tissue-specific activation of a cloned α-fetoprotein gene during differentiation of a transfected embryonal carcinoma cell line

1984 • 120 citations

Epithelial layer formation in differentiating aggregates of F9 embryonal carcinoma cells.

1983 • 117 citations

High expression of cloned immunoglobulin k gene in transgenic mice is restricted to B lymphocytes

1984 • 114 citations

Human β-Globin Gene Sequences Injected into Mouse Eggs, Retained in Adults, and Transmitted to Progeny

1982 • 90 citations

Role of laminin in epithelium formation by F9 aggregates.

1983 • 89 citations

Synthesis of secretory proteins in developing mouse yolk sac

1982 • 49 citations

Genetic Analysis of α-Fetoprotein Synthesis in Mice

1982 • 39 citations

Transient Expression of a Mouse α-Fetoprotein Minigene: Deletion Analyses of Promoter Function

1983 • 36 citations

Stability of α-fetoprotein messenger RNA in mouse yolk sac

1982 • 35 citations

Induction of α-Fetoprotein Synthesis in Differentiating F9 Teratocarcinoma Cells Is Accompanied by a Genome-Wide Loss of DNA Methylation

1984 • 25 citations