Cytokines in autoimmunity

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Localization of Tumor Necrosis Factor α in Synovial Tissues and at the Cartilage–Pannus Junction in Patients With Rheumatoid Arthritis

1991 • 585 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

Interleukin-10

1992 • 303 citations

Expression of granulocyte‐macrophage colony‐stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor‐α

1991 • 290 citations

Soluble cytokine receptors: their role in immunoregulation

1991 • 289 citations

Autoimmune diabetes as a consequence of locally produced interleukin-2

1992 • 242 citations

Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.

1991 • 226 citations

Localization of tumor necrosis factor receptors in the synovial tissue and cartilage‐pannus junction in patients with rheumatoid arthritis. Implications for local actions of tumor necrosis factor α

1992 • 216 citations

Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.

1991 • 204 citations

Alpha 4/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes.

1992 • 202 citations

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia.

1991 • 198 citations

LOCALIZATION OF INTERLEUKIN-1α, TYPE 1 INTERLEUKIN-1 RECEPTOR AND INTERLEUKIN-1 RECEPTOR ANTAGONIST IN THE SYNOVIAL MEMBRANE AND CARTILAGE/PANNUS JUNCTION IN RHEUMATOID ARTHRITIS

1992 • 187 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β

1991 • 167 citations

Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritis.

1989 • 166 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium.

1992 • 124 citations

Engagement of major histocompatibility complex class II molecules by superantigen induces inflammatory cytokine gene expression in human rheumatoid fibroblast-like synoviocytes.

1992 • 103 citations

GMP‐140 (P‐selectin/CD62) binds to chronically stimulated but not resting CD4⁺ T lymphocytes and regulates their production of proinflammatory cytokines

1992 • 93 citations

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

1992 • 93 citations

Transforming growth factor-β1 in rheumatoid synovial membrane and cartilage pannus junction

1991 • 93 citations

Cytokine Assays: Role in Evaluation of the Pathogenesis of Autoimmunity

1991 • 83 citations

Cytokines in sera from insulin-dependent diabetic patients at diagnosis

1991 • 78 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis

1992 • 70 citations

Lymphocyte homing to sites of inflammation

1992 • 55 citations

Aberrant expression of HLA-DR antigens by insulin-containing beta-cells in recent-onset type I diabetes mellitus

1986 • 44 citations

Interleukin 2 receptor targeted fusion toxin (DAB₄₈₆‐IL‐2) treatment blocks diabetogenic autoimmunity in non‐obese diabetic mice

1992 • 41 citations

Interleukin-1 enhances the development of type II collagen-induced arthritis only in susceptible and not in resistant mice

1992 • 33 citations

Flare-up of experimental arthritis in mice with murine recombinant IL-1

1992 • 32 citations

Inhibitors of interleukin 1 activity in synovial fluids and in cultured synovial fluid mononuclear cells.

1992 • 32 citations

Granulocyte–macrophage colony‐stimulating factor augments neutrophil‐mediated cartilage degradation and neutrophil adherence

1991 • 31 citations

Increased in vivo production of tumor necrosis factor after development of diabetes in nontreated, long-term diabetic BB rats

1992 • 30 citations