Phylogenetic Footprinting Reveals a Nuclear Protein Which Binds to Silencer Sequences in the Human y and e Globin Genes

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

1980 • 2,034 citations

Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide

1971 • 1,371 citations

Transcriptional repression by YY1, a human GLI-Krüippel-related protein, and relief of repression by adenovirus E1A protein

1991 • 1,023 citations

A simple phase-extraction assay for chloramphenicol acyltransferase activity

1988 • 1,006 citations

HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression

1982 • 655 citations

The "beta-like-globin" gene domain in human erythroid cells.

1985 • 634 citations

Erythroid-specific expression of human beta-globin genes in transgenic mice.

1985 • 436 citations

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

1988 • 432 citations

The Molecular Genetics of Human Hemoglobin

1984 • 420 citations

A developmentally stable chromatin structure in the human beta-globin gene cluster.

1986 • 391 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Embryonic ε and γ globin genes of a prosimian primate (Galago crassicaudatus)

1988 • 368 citations

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

1990 • 364 citations

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

1991 • 357 citations

Developmental regulation of β-globin gene switching

1988 • 328 citations

Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.

1991 • 303 citations

Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

1990 • 301 citations

Increased γ-globin expression in a nondeletion HPFH mediated by an erythroid-specif ic DNA-binding factor

1989 • 298 citations

Human gamma- to beta-globin gene switching in transgenic mice.

1990 • 291 citations

Regulated expression of human Aγ-, β-, and hybrid γβ-globin genes in transgenic mice: Manipulation of the developmental expression patterns

1986 • 275 citations

A single erythroid-specific DNase I super-hypersensitive site activates high levels of human beta-globin gene expression in transgenic mice.

1989 • 269 citations

Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits.

1990 • 264 citations

An embryonic pattern of expression of a human fetal globin gene in transgenic mice

1986 • 204 citations

A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast.

1991 • 198 citations

Human γ-globin genes silenced independently of other genes in the β-globin locus

1991 • 191 citations

DNasel hypersensitive sites 1, 2 and 3 of the human β-globin dominant control region direct position-independent expression

1990 • 186 citations

Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.

1989 • 158 citations

Identification of a stage selector element in the human gamma-globin gene promoter that fosters preferential interaction with the 5′ HS2 enhancer when in competition with the beta-promoter.

1992 • 148 citations

Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site.

1989 • 122 citations

Cooperative interactions between transcription factors Sp1 and OTF-1.

1990 • 114 citations

Nuclear Proteins That Bind the Human ϒ-Globin Gene Promoter: Alterations in Binding Produced by Point Mutations Associated with Hereditary Persistence of Fetal Hemoglobin

1988 • 112 citations

Site-independent expression of the chicken βA-globin gene in transgenic mice

1990 • 106 citations

The effects of HPFH mutations in the human γ-globin promoter on binding of ubiquitous and erythroid specific nuclear factors

1988 • 91 citations

Demonstration of a human epsilon-globin gene silencer with studies in transgenic mice

1992 • 53 citations

The upstream region of the human gamma-globin gene promoter. Identification and functional analysis of nuclear protein binding sites

1991 • 48 citations

Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02

1991 • 44 citations

Interaction of Sp1 with the human gamma globin promoter: binding and transactivation of normal and mutant promoters

1991 • 42 citations

Mutations in two regions upstream of the^Aγ globin gene canonical promoter affect gene expression

1989 • 39 citations

HLA antigen structural gene mutants selected with an allospecific monoclonal antibody.

1982 • 36 citations

The -175T----C mutation increases promoter strength in erythroid cells: correlation with evolutionary conservation of binding sites for two trans-acting factors

1990 • 28 citations

The β globin gene cluster of the prosimian primate Galago crassicaudatus: Nucleotide sequence determination of the 41-kb cluster and comparative sequence analyses

1992 • 26 citations