Activated Platelets and Monocytes Generate Four Hydroxyphosphatidylethanolamines via Lipoxygenase

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

1999 • 835 citations

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice

1999 • 518 citations

Myeloperoxidase Functions as a Major Enzymatic Catalyst for Initiation of Lipid Peroxidation at Sites of Inflammation

2002 • 427 citations

The role of selenium peroxidases in the protection against oxidative damage of membranes

1987 • 386 citations

A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense

2005 • 306 citations

Electrospray ionization tandem mass spectrometry of glycerophosphoethanolamine plasmalogen phospholipids

2004 • 262 citations

Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages

1996 • 249 citations

A lipoxygenase in rabbit reticulocytes which attacks phospholipids and intact mitochondria

1975 • 202 citations

Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

1990 • 164 citations

Resistance to type 1 diabetes induction in 12-lipoxygenase knockout mice

1999 • 157 citations

Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids

1987 • 152 citations

Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation

2006 • 137 citations

Membrane Translocation of 15-Lipoxygenase in Hematopoietic Cells Is Calcium-Dependent and Activates the Oxygenase Activity of the Enzyme

1998 • 132 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis

1995 • 120 citations

Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia

2002 • 104 citations

Separation of phospholipids by high-performance liquid chromatography: All major classes, including ethanolamine and choline plasmalogens, and most minor classes, including lysophosphatidylethanolamine

1986 • 95 citations

Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages.

1982 • 93 citations

Substitution of 15-hydroxyeicosatetraenoic acid in the phosphoinositide signaling pathway.

1991 • 88 citations

12/15-Lipoxygenase Translocation Enhances Site-specific Actin Polymerization in Macrophages Phagocytosing Apoptotic Cells

2001 • 74 citations

IL-4 Induces Apoptosis in A549 Lung Adenocarcinoma Cells: Evidence for the Pivotal Role of 15-Hydroxyeicosatetraenoic Acid Binding to Activated Peroxisome Proliferator-Activated Receptor γ Transcription Factor

2003 • 74 citations

Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate

1987 • 64 citations

Esterification of monohydroxyfatty acids into the lipids of a macrophage cell line

1983 • 60 citations

Platelet 12-Lipoxygenase Activation via Glycoprotein VI

2004 • 54 citations

Conversion of 15-hydroxyeicosatetraenoic acid to 11-hydroxyhexadecatrienoic acid by endothelial cells

1988 • 53 citations

Elevated Endothelial Nitric Oxide Bioactivity and Resistance to Angiotensin-Dependent Hypertension in 12/15-Lipoxygenase Knockout Mice

2005 • 50 citations

Cellular and Molecular Mechanisms of the Selective Regulation of IL-12 Production by 12/15-Lipoxygenase

2006 • 49 citations

The Hepoxilins

1999 • 45 citations

Interleukin-4 Enhances 15-Lipoxygenase Activity and Incorporation of 15(S)-HETE into Cellular Phospholipids in Cultured Pulmonary Epithelial Cells

1999 • 41 citations

Modulation of the beta-adrenergic response of cardiomyocytes by specific lipoxygenase products involves their incorporation into phosphatidylinositol and activation of protein kinase C.

1994 • 38 citations

Human Tracheal Epithelial Cells Selectively Incorporate 15-Hydroxyeicosatetraenoic Acid into Phosphatidylinositol

1993 • 27 citations

Lipoxygenase metabolism of endogenous and exogenous arachidonate in leukocytes: GC-MS analyses of incubations in H218O buffers

1986 • 23 citations

Composition and metabolism of phospholipids of human leukocytes

1982 • 23 citations

Preferential Esterification of Endogenously Formed 5‐Hydroxyeicosatetraenoic Acid to Phospholipids in Activated Polymorphonuclear Leukocytes

1997 • 21 citations

15-HETE: Selective incorporation into inositol phospholipids of MDCK cells

1994 • 21 citations

Interactions of 12‐lipoxygenase with phospholipase A₂ isoforms following platelet activation through the glycoprotein VI collagen receptor

2004 • 16 citations

Incorporation of 12(S) -hydroxyeicosatetraenoic acid into phospholipids and active diacylglycerols in rat liver epithelial cells: effects on DNA synthesis

1996 • 11 citations

Phospholipid composition of human monocytes and alterations occurring due to culture and stimulation by C3b

1984 • 11 citations

Incorporation of 12(S)-hydroxyeicosatetraenoic acid into the phosphatidylcholine signaling pathway

1996 • 9 citations

Substitution of 15(S)hydroxyeicosatetraenoic acid in phosphatidylinositol alters the growth of liver epithelial cells

1997 • 6 citations