Evidence from Mutation Spectra that the UV Hypermutability of Xeroderma Pigmentosum Variant Cells Reflects Abnormal, Error-Prone Replication on a Template Containing Photoproducts

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986 • 884 citations

Xeroderma Pigmentosum

1974 • 755 citations

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.

1975 • 617 citations

Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells

1976 • 331 citations

(6–4)Photoproducts are removed from the DNA of UV-irradiated mammalian cells more efficiently than cyclobutane pyrimidine dimers

1985 • 280 citations

Xeroderma Pigmentosum: Variants with Normal Dna Repair and Normal Sensitivity to Ultraviolet Light

1972 • 244 citations

The specificity of UV-induced mutations at an endogenous locus in mammalian cells.

1987 • 216 citations

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells.

1986 • 215 citations

Cell Cycle-Dependent Strand Bias for UV-Induced Mutations in the Transcribed Strand of Excision Repair-Proficient Human Fibroblasts but Not in Repair-Deficient Cells

1991 • 169 citations

Amplification and direct nucleotide sequencing of cDNA from the lysate of low numbers of diploid human cells

1989 • 138 citations

Repair of UV-endonuclease-susceptible sites in the 7 complementation groups of xeroderma pigmentosum a through G

1979 • 132 citations

Mechanisms of inhibition of DNA replication by ultraviolet light in normal human and xeroderma pigmentosum fibroblasts

1981 • 121 citations

Pyrimidine Photodimers

1976 • 119 citations

Postreplication repair: questions of its definition and possible alteration in xeroderma pigmentosum cell strains.

1979 • 101 citations

Fidelity of a human cell DNA replication complex.

1988 • 93 citations

Extent of excision repair before DNA synthesis determines the mutagenic but not the lethal effect of UV radiation

1982 • 82 citations

Ultraviolet mutagenesis of normal and xeroderma pigmentosum variant human fibroblasts

1979 • 76 citations

Xeroderma pigmentosum variant cells are less likely than normal cells to incorporate dAMP opposite photoproducts during replication of UV-irradiated plasmids.

1991 • 74 citations

Xeroderma pigmentosum variants have a slow recovery of DNA synthesis after irradiation with ultraviolet light

1979 • 73 citations

In vitro bypass of UV-induced lesions by Escherichia coli DNA polymerase I: specificity of nucleotide incorporation.

1983 • 67 citations

Sequence effect on alkali-sensitive sites in UV-irradiated SV40 DNA

1987 • 65 citations

XERODERMA PIGMENTOSUM FIBROBLASTS INCLUDING CELLS FROM XP VARIANTS ARE ABNORMALLY SENSITIVE TO THE MUTAGENIC AND CYTOTOXIC ACTION OF BROAD SPECTRUM SIMULATED SUNLIGHT

1984 • 51 citations

DNA Strand Specificity for UV-Induced Mutations in Mammalian Cells

1989 • 44 citations

The frequency of mutants in human fibroblasts UV-irradiated at various times during S-phase suggests that genes for thioguanine- and diphtheria toxin-resistance are replicated early

1985 • 19 citations

Modulation of an ultraviolet mutational hotspot in a shuttle vector in Xeroderma cells

1991 • 17 citations