Prognostic significance of proliferative activity, DNA‐ploidy, p53 and Ki‐ras point mutations in colorectal liver metastases

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Regression Models and Life-Tables

1972 • 27,145 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Cancer: Principles and Practice of Oncology

1997 • 1,408 citations

MATHEMATICAL ANALYSIS OF DNA DISTRIBUTIONS DERIVED FROM FLOW MICROFLUOROMETRY

1974 • 795 citations

The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins.

1993 • 756 citations

Surgery of the liver and biliary tract

2001 • 389 citations

Cell cycle dependent expression and stability of the nuclear protein detected by Ki‐67 antibody in HL‐60 cells

1992 • 368 citations

Association of p53 mutations with short survival in colorectal cancer

1994 • 357 citations

‘Cold SSCP’: a simple, rapid and non-radioactive method for optimized single-strand conformation polymorphism analyses

1993 • 335 citations

Technical and Biological Factors in Disease-Free Survival After Hepatic Resection for Colorectal Cancer Metastases

1992 • 270 citations

Modalities of synthesis of Ki67 antigen during the stimulation of lymphocytes

1991 • 193 citations

Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells.

1989 • 183 citations

Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival

1995 • 183 citations

Consensus review of the clinical utility of dna flow cytometry in colorectal cancer

1993 • 112 citations

Prognostic significance of the MIB-1 proliferation index for patients with squamous cell carcinoma of the esophagus

1995 • 104 citations

Prognostic value of TP53 and K-ras-2 mutational analysis in stage III carcinoma of the colon

1996 • 81 citations

Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.

1995 • 79 citations

Ki67 Index and S-Phase Fraction in Human Breast Carcinomas: Comparison and Correlations with Prognostic Factors

1990 • 78 citations

A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma.

1994 • 77 citations

Thymidine Labeling Index, Flow Cytometric S-Phase Measurement, and DNA Index in Human Tumors: Comparisons and Correlations

1988 • 77 citations

MIB-1, Ki67, and PCNA scores and DNA flow cytometry in intermediate grade malignant lymphomas.

1994 • 75 citations

Nonisotopic SSCP detection in PCR products by ethidium bromide staining

1992 • 74 citations

Tumor DNA Content in Primary and Metastatic Colorectal Carcinoma

1986 • 53 citations

Interlaboratory reproducibility of semiautomated cell cycle analysis of flow cytometric DNA-histograms obtained from fresh material of 1,295 breast cancer cases

1996 • 49 citations

Comparison of MIB-1 proliferation index with S-phase fraction in human breast carcinomas

1996 • 43 citations

Formal Hepatic Resection of Colorectal Liver Metastases Ploidy and Prognosis

1992 • 43 citations

Quality control for evaluation of the S-phase fraction by flow cytometry: A multicentric study

1994 • 36 citations

Prognostic significance of cell kinetics in laryngeal squamous cell carcinoma: clinicopathological associations.

1995 • 34 citations

Cell kinetics: prognostic and therapeutic implications in human tumours

1994 • 33 citations

Flow-Cytometric Analysis of Colorectal Cancer with Hepatic Metastases and Its Relationship to Metastatic Characteristics and Prognosis

1990 • 20 citations

Reproducibility of semi-automated cell cycle analysis of flow cytometric DNA-histograms of fresh breast cancer material.

1995 • 19 citations

Colorectal cell kinetics

1996 • 16 citations

Image analysis of in situ cell cycle related changes of PCNA and Ki‐67 proliferating antigen expression

1994 • 16 citations

Patterns of DNA‐ploidy in operable colorectal carcinoma: A prospective study of 100 cases

1991 • 14 citations

Cell Kinetics of Hepatic Metastases as a Prognostic Marker in Patients With Advanced Colorectal Carcinoma

1990 • 14 citations

ras and myc analysis in primary and metastatic colorectal carcinomas

1997 • 11 citations

p53 Mutations in primary colorectal adenocarcinomas and liver metastases

1996 • 11 citations

Optimization of RNA and DNA purification procedures from human colorectal carcinomas.

1993 • 7 citations

Point mutation of the c-Ki-ras proto-oncogene and the p53 tumour suppressor gene in distal colonic adenocarcinomas

1996 • 4 citations