Cytokine-Inducible SH2-Containing Protein Suppresses PRL Signaling by Binding the PRL Receptor

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

High-Efficiency Transformation of Mammalian Cells by Plasmid DNA

1987 • 729 citations

Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription.

1994 • 599 citations

Stat5 Is Required for IL-2-Induced Cell Cycle Progression of Peripheral T Cells

1999 • 554 citations

CIS, a Cytokine Inducible SH2 Protein, Is a Target of the JAK-STAT5 Pathway and Modulates STAT5 Activation

1997 • 538 citations

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

1999 • 531 citations

Gigantism in mice lacking suppressor of cytokine signalling-2

2000 • 492 citations

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

2000 • 465 citations

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

1999 • 428 citations

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

2000 • 393 citations

SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis

1999 • 372 citations

SOCS/CIS Protein Inhibition of Growth Hormone-stimulated STAT5 Signaling by Multiple Mechanisms

1999 • 364 citations

CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2

2000 • 339 citations

Suppression of STAT5 Functions in Liver, Mammary Glands, and T Cells in Cytokine-Inducible SH2-Containing Protein 1 Transgenic Mice

1999 • 269 citations

Cloning and Characterization of Novel CIS Family Genes

1997 • 259 citations

Prolactin-induced proliferation of Nb2 cells involves tyrosine phosphorylation of the prolactin receptor and its associated tyrosine kinase JAK2.

1994 • 226 citations

Negative regulators of cytokine signal transduction

1999 • 224 citations

Inhibition and Restoration of Prolactin Signal Transduction by Suppressors of Cytokine Signaling

1999 • 197 citations

Cutting Edge: SOCS-1 Is a Potent Inhibitor of IL-4 Signal Transduction

1999 • 183 citations

STAT5A-Deficient Mice Demonstrate a Defect in Granulocyte-Macrophage Colony-Stimulating Factor–Induced Proliferation and Gene Expression

1997 • 180 citations

Dual effects of suppressor of cytokine signaling (SOCS‐2) on growth hormone signal transduction

1999 • 127 citations

Comparative Endocrinology of Prolactin

1980 • 124 citations

Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone

2000 • 123 citations

TRANSGENIC MODELS OF GROWTH HORMONE ACTION

1999 • 121 citations

Antagonistic Properties of Human Prolactin Analogs That Show Paradoxical Agonistic Activity in the Nb2 Bioassay

1996 • 118 citations

Tyrosine Docking Sites of the Rat Prolactin Receptor Required for Association and Activation of Stat5

1997 • 95 citations

CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells

1998 • 93 citations

Suppressor of Cytokine Signaling (SOCS)-3 Protein Interacts with the Insulin-like Growth Factor-I Receptor

2000 • 88 citations

Cytokine‐inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor‐mediated STAT5 signaling

1998 • 87 citations

Mechanism of Inhibition of Growth Hormone Receptor Signaling by Suppressor of Cytokine Signaling Proteins

1999 • 61 citations

SOCS-1, -2, -3: selective targets and functions downstream of the prolactin receptor

1999 • 59 citations

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation

1996 • 53 citations

Human growth hormone-variant demonstrates a receptor binding profile distinct from that of normal pituitary growth hormone.

1990 • 53 citations

Functional activity of the human prolactin receptor and its ligands

1995 • 20 citations