Disease proteomics

Molecular portraits of human breast tumours

2000 • 15,445 citations

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

2001 • 10,602 citations

A Gene-Expression Signature as a Predictor of Survival in Breast Cancer

2002 • 6,428 citations

A proteomic view of the Plasmodium falciparum life cycle

2002 • 1,310 citations

Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissues

2001 • 1,151 citations

Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front

2001 • 954 citations

A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens

1998 • 712 citations

Endoplasmic Reticulum-Mediated Phagocytosis Is a Mechanism of Entry into Macrophages

2002 • 682 citations

Autoantigen microarrays for multiplex characterization of autoantibody responses

2002 • 680 citations

Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry

2002 • 657 citations

Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

2002 • 565 citations

Clinical proteomics: translating benchside promise into bedside reality

2002 • 555 citations

Global Profiling of the Cell Surface Proteome of Cancer Cells Uncovers an Abundance of Proteins with Chaperone Function

2003 • 519 citations

Detection technologies in proteome analysis

2002 • 478 citations

Contribution of Human α-Defensin 1, 2, and 3 to the Anti-HIV-1 Activity of CD8 Antiviral Factor

2002 • 475 citations

2D Differential In-gel Electrophoresis for the Identification of Esophageal Scans Cell Cancer-specific Protein Markers

2002 • 393 citations

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

2002 • 344 citations

Fingerprinting the circulating repertoire of antibodies from cancer patients

2002 • 334 citations

An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer

2001 • 311 citations

Proteomic profiling of the cancer microenvironment by antibody arrays

2001 • 308 citations

Bacillus subtilisfunctional genomics: global characterization of the stringent response by proteome and transcriptome analysis

2002 • 295 citations

Chemical Approaches for Functionally Probing the Proteome

2002 • 293 citations

Identification of Novel MAP Kinase Pathway Signaling Targets by Functional Proteomics and Mass Spectrometry

2000 • 246 citations

Functional Proteomic Analysis of Protein Kinase C ε Signaling Complexes in the Normal Heart and During Cardioprotection

2001 • 201 citations

Individually addressable parallel peptide synthesis on microchips

2002 • 190 citations

Diagnosis of cellular states of microbial organisms using proteomics

1999 • 186 citations

Immunoproteomics of Helicobacter pylori infection and relation to gastric disease

2002 • 169 citations

Zooming-in on the proteome: Very narrow-range immobilised pH gradients reveal more protein species and isoforms

2001 • 159 citations

Preparative two-dimensional gel electrophoresis at alkaline pH using narrow range immobilized pH gradients

2002 • 152 citations

Identification of Surface Proteins of Helicobacter pylori by Selective Biotinylation, Affinity Purification, and Two-dimensional Gel Electrophoresis

2002 • 151 citations

Two-dimensional map of the proteome ofHaemophilus influenzae

2000 • 150 citations

Comprehensive analysis of complex proteomes using microscale solution isoelectrofocusing prior to narrow pH range two-dimensional electrophoresis

2002 • 142 citations

Protein based microarrays: A tool for probing the proteome of cancer cells and tissues

2001 • 126 citations

Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients

1995 • 113 citations

Integrated Microfluidic System Enabling (Bio)chemical Reactions with On-Line MALDI-TOF Mass Spectrometry

2002 • 110 citations

The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy

1996 • 109 citations

Proteomic Analysis of Pharmacologically Preconditioned Cardiomyocytes Reveals Novel Phosphorylation of Myosin Light Chain 1

2001 • 109 citations

Effects of Calcium, Inorganic Phosphate, and pH on Isometric Force in Single Skinned Cardiomyocytes From Donor and Failing Human Hearts

2001 • 98 citations

A Functional Proteomics Screen of Proteases In Colorectal Carcinoma

2000 • 95 citations

Stabilization of cell wall proteins in Bacillus subtilis: A proteomic approach

2002 • 85 citations

Protein changes observed in pacing‐induced heart failure using two‐dimensional electrophoresis

1998 • 82 citations

Construction of HSC‐2DPAGE: A two‐dimensional gel electrophoresis database of heart proteins

1997 • 81 citations

Identification of novel targets for cancer therapy using expression proteomics

2002 • 78 citations

Detection of auto-antibodies against L-myc oncogene products in sera from lung cancer patients

1996 • 63 citations

Contribution of proteomics to tumor immunology

2001 • 52 citations

Postgenomic Analysis of Four Novel Antigens of Group A Streptococcus : Growth Phase-Dependent Gene Transcription and Human Serologic Response

2002 • 50 citations

A two-dimensional electrophoresis database of rat heart proteins

1999 • 45 citations

Molecular profiling of breast cancer: portraits but not physiognomy.

2001 • 35 citations

Functional proteomics using chromophore- assisted laser inactivation

2002 • 29 citations

Bacterial Proteomics and Vaccine Development

2002 • 26 citations

Functional proteomics to study protection of the ischaemic myocardium

2002 • 6 citations