Identification of Allosteric Peptide Agonists of CXCR4

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

1996 • 4,184 citations

Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene

1996 • 2,883 citations

CC CKR5: A RANTES, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1

1996 • 2,735 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors

1998 • 2,421 citations

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1996 • 2,374 citations

Human Chemokines: An Update

1997 • 2,235 citations

The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

1998 • 1,535 citations

A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

1996 • 1,482 citations

The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

1997 • 1,414 citations

Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors

2000 • 1,199 citations

Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry

1998 • 990 citations

G Protein-Coupled Receptor Allosterism and Complexing

2002 • 910 citations

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

1998 • 755 citations

Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1

1997 • 724 citations

CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

1996 • 669 citations

In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression

1997 • 642 citations

Structure, Function, and Inhibition of Chemokines

2002 • 599 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

A Low-Molecular-Weight Inhibitor against the Chemokine Receptor CXCR4: A Strong Anti-HIV Peptide T140

1998 • 298 citations

Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor

2001 • 260 citations

Trafficking of the HIV Coreceptor CXCR4

1999 • 258 citations

A Point Mutation That Confers Constitutive Activity to CXCR4 Reveals That T140 Is an Inverse Agonist and That AMD3100 and ALX40-4C Are Weak Partial Agonists

2002 • 246 citations

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

2001 • 236 citations

Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions

1999 • 229 citations

Control of Yeast Mating Signal Transduction by a Mammalian β ₂ -adrenergic Receptor and G _s α Subunit

1990 • 224 citations

Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker

1995 • 209 citations

Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent

1997 • 183 citations

Structural requirements for interleukin-8 function identified by design of analogs and CXC chemokine hybrids.

1994 • 182 citations

Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein ?-subunit chimeras

2000 • 170 citations

Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity

1998 • 167 citations

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast

1998 • 155 citations

Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1α, a potent ligand for the HIV-1 “fusin” coreceptor

1998 • 151 citations

N-terminal Peptides of Stromal Cell-derived Factor-1 with CXC Chemokine Receptor 4 Agonist and Antagonist Activities

1998 • 148 citations

Determinants for Sensitivity of Human Immunodeficiency Virus Coreceptor CXCR4 to the Bicyclam AMD3100

1998 • 142 citations

Functional Coupling of a Mammalian Somatostatin Receptor to the Yeast Pheromone Response Pathway

1995 • 133 citations

C5a Receptor Activation

1999 • 124 citations

Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides

1998 • 123 citations

Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic Acid

1998 • 118 citations

Mutation of Asp¹⁷¹and Asp²⁶²of the Chemokine Receptor CXCR4 Impairs Its Coreceptor Function for Human Immunodeficiency Virus-1 Entry and Abrogates the Antagonistic Activity of AMD3100

2001 • 114 citations

T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure

1999 • 112 citations

Safe Use of the CXCR4 Inhibitor ALX40-4C in Humans

2001 • 109 citations

Caspase-Dependent Apoptosis of Cells Expressing the Chemokine Receptor CXCR4 Is Induced by Cell Membrane-Associated Human Immunodeficiency Virus Type 1 Envelope Glycoprotein (gp120)

2000 • 107 citations

Effect of Mutations in the Second Extracellular Loop of CXCR4 on Its Utilization by Human and Feline Immunodeficiency Viruses

1999 • 93 citations

Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1α: implications for development of selective CXCR4 antagonists

2001 • 83 citations

Use of G-protein fusions to monitor integral membrane protein–protein interactions in yeast

2000 • 70 citations

Chemically Synthesized SDF-1α Analogue, N33A, Is a Potent Chemotactic Agent for CXCR4/Fusin/LESTR-expressing Human Leukocytes

1997 • 66 citations

Strong in Vitro Synergy Between the Fusion Inhibitor T-20 and the CXCR4 Blocker AMD-3100

2000 • 63 citations

Single Amino Acid Substitutions and Deletions That Alter the G Protein Coupling Properties of the V2 Vasopressin Receptor Identified in Yeast by Receptor Random Mutagenesis

2001 • 58 citations

Functional expression of M₁, M₃ and M₅ muscarinic acetylcholine receptors in yeast

2001 • 58 citations

Structure-Activity Relationships of G Protein-Coupled Receptors

1999 • 57 citations

Genetic Mapping of the Human C5a Receptor

2000 • 56 citations

Yeast α Mating Factor Structure-Activity Relationship Derived from Genetically Selected Peptide Agonists and Antagonists of Ste2p

1996 • 53 citations

Expression and Functional Characterization of Mutant Human CXCR4 in Insect Cells: Role of Cysteinyl and Negatively Charged Residues in Ligand Binding

2000 • 39 citations

The Role of Positively Charged Residues in CXCR4 Recognition Probed with Synthetic Peptides

1999 • 24 citations