The role of IL-10 in crossregulation of TH1 and TH2 responses

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

DNA sequence and expression of the B95-8 Epstein—Barr virus genome

1984 • 2,039 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

1990 • 1,155 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

1990 • 977 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-gamma.

1986 • 727 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1

1990 • 539 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.

1988 • 359 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10

1990 • 347 citations

The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones.

1989 • 304 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

Regulation of T‐Cell Activation; Differences among T‐Cell Subsets

1989 • 271 citations

Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay.

1990 • 247 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

1989 • 237 citations

T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.

1986 • 218 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

1989 • 206 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Production of lymphokine mRNA by CD45R+ and CD45R- helper T cells from human peripheral blood and by human CD4+ T cell clones.

1989 • 169 citations

Separation of events mediating B cell proliferation and Ig production by using T cell membranes and lymphokines.

1990 • 150 citations

Analysis of the defects responsible for the impaired regulation of Epstein-Barr virus-induced B cell proliferation by rheumatoid arthritis lymphocytes. I. Diminished gamma interferon production in response to autologous stimulation.

1983 • 146 citations

CD4+ T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro.

1990 • 141 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

Selectively increased production of interferon-gamma by subsets of Lyt-2+ and L3T4+ T cells identified by expression of Pgp-1.

1987 • 120 citations

One-signal requirement for interferon-gamma production by human large granular lymphocytes.

1987 • 116 citations

Regulation of Epstein‐Barr virus infection by recombinant interferons. Selected sensitivity to interferon‐γ

1985 • 105 citations

Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4.

1990 • 103 citations

Murine CD4+ T cell subsets defined.

1988 • 102 citations

Large granular lymphocytes inhibit the in vitro growth of autologous Epstein-Barr virus-infected B cells

1983 • 101 citations

The short unique region of the B95-8 Epstein-Barr virus genome

1985 • 90 citations

Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.

1989 • 71 citations

Cognate interactions between helper T cells and B cells. II. Dissection of cognate help by using a class II-restricted, antigen-specific, IL-2-dependent helper T cell clone.

1989 • 44 citations

Differential interleukin-2 and interferon-γ production by human lymphocyte cultures exceptionally resistant to Epstein-Barr virus immortalization

1989 • 25 citations