Selective Expansion of Alveolar Macrophages In Vivo by Adenovirus-Mediated Transfer of the Murine Granulocyte-Macrophage Colony-Stimulating Factor cDNA

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1993 • 1,767 citations

Chronic Granulomatous Disease: Report on a National Registry of 368 Patients

2000 • 1,680 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Involvement of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Homeostasis

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Stepwise dismantling of adenovirus 2 during entry into cells

1993 • 810 citations

Manipulation of Adenovirus Vectors

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Adenovirus-Mediated Transfer of a Recombinant α1-Antitrypsin Gene to the Lung Epithelium in Vivo

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1982 • 705 citations

A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells

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Molecular physiology of granulocyte-macrophage colony-stimulating factor

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The alveolar macrophage

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Molecular physiology of granulocyte-macrophage colony-stimulating factor

1991 • 505 citations

Innate Immune Mechanisms Dominate Elimination of Adenoviral Vectors FollowingIn VivoAdministration

1997 • 497 citations

Induction of Macrophage Tumoricidal Activity by Granulocyte-Macrophage Colony-Stimulating Factor

1986 • 418 citations

Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF

1986 • 405 citations

Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage

1987 • 384 citations

Upregulation of integrins alpha v beta 3 and alpha v beta 5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery

1995 • 292 citations

Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis

1983 • 256 citations

Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells

1996 • 237 citations

Transfer of granulocyte-macrophage colony-stimulating factor gene to rat lung induces eosinophilia, monocytosis, and fibrotic reactions.

1996 • 229 citations

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1994 • 223 citations

Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung.

1984 • 219 citations

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

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A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor.

1989 • 198 citations

Comparison of the effects of IL-3, granulocyte-macrophage colony-stimulating factor, and macrophage colony-stimulating factor in supporting monocyte differentiation in culture. Analysis of macrophage antibody-dependent cellular cytotoxicity.

1990 • 197 citations

Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages.

1987 • 194 citations

Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone marrow transduced by a retroviral vector.

1992 • 183 citations

Receptor-mediated gene transfer into macrophages.

1996 • 176 citations

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1995 • 158 citations

Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector.

1995 • 149 citations

Gene Transfer by DNA/Glycosylated Polylysine Complexes into Human Blood Monocyte-Derived Macrophages

1996 • 142 citations

Role of Alveolar Macrophages in Rapid Elimination of Adenovirus Vectors Administered to the Epithelial Surface of the Respiratory Tract

1997 • 133 citations

The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters.

1985 • 129 citations

Role of granulocyte/macrophage colony-stimulating factor in the regulation of murine alveolar macrophage proliferation and differentiation.

1988 • 128 citations

Organ specific cytokine therapy. Local activation of mononuclear phagocytes by delivery of an aerosol of recombinant interferon-gamma to the human lung.

1991 • 127 citations

Granulocyte-macrophage colony-stimulating factor promotes the proliferation of human alveolar macrophages in vitro.

1991 • 110 citations

GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice

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Macrophage depletion increases the safety, efficacy and persistence of adenovirus-mediated gene transfer in vivo

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Alveolar macrophage dysfunction in human bone marrow transplant recipients

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1994 • 78 citations

Effect of Adenoviral Vector Infection on Cell Proliferation in Cultured Primary Human Airway Epithelial Cells

1995 • 77 citations

Tropism of human adenovirus type 5-based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus

1996 • 73 citations

Persistent infection of human adenovirus type 5 in human monocyte cell lines

1992 • 69 citations

Maintenance of the normal rat alveolar macrophage cell population. The roles of monocyte influx and alveolar macrophage proliferation in situ.

1987 • 69 citations

Efficient Adenovirus-Mediated Gene Transfer into Human Blood Monocyte-Derived Macrophages

1993 • 64 citations

Adenoviral Transfection of Isolated Pancreatic Islets: A Study of Programmed Cell Death (Apoptosis) and Islet Function

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Mechanisms of Macrophage Accumulation in the Lungs of Asbestos-Exposed Subjects

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Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia.

1982 • 58 citations

Granulocyte-Macrophage Colony Stimulating Factor and Pneumocystis carinii Pneumonia in Mice

1995 • 56 citations

Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis.

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Activation of alveolar macrophages and lung host defenses using transfer of the interferon-gamma gene

1997 • 54 citations

Targeted gene delivery to alveolar macrophages via Fc receptor-mediated endocytosis.

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Expression of HLA Class II Genes in Alveolar Macrophages of Patients with Sarcoidosis

1989 • 40 citations

Adenovirus-mediated gene transfer into monocyte-derived macrophages of patients with X-linked chronic granulomatous disease: ex vivo correction of deficient respiratory burst

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Use of an autonomous parvovirus vector for selective transfer of a foreign gene into transformed human cells of different tissue origins and its expression therein

1994 • 38 citations

Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector

1997 • 36 citations

Effects of granulocyte and granulocyte-macrophage colony-stimulating factors in a neutropenic murine model of trichosporonosis

1997 • 34 citations

Alveolar Macrophage Dysfunction in Systemic Lupus Erythematosus

1987 • 33 citations

The Effect of Aerosolized Recombinant Human Granulocyte Macrophage Colony-stimulating Factor on Lung Leukocytes in Nonhuman Primates

1992 • 28 citations

Granulocyte-macrophage colony stimulating factor and Pneumocystis carinii pneumonia in mice.

1995 • 27 citations

Retroviral-mediated gene expression in human myelomonocytic cells: a comparison of hematopoietic cell promoters to viral promoters

1995 • 27 citations

Pulmonary bacterial clearance and alveolar macrophage function in septic shock lung.

1984 • 23 citations

Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA

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Gene transfer to primary chronic granulomatous disease monocytes

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Delivery of Human Interferon-γ via Gene TransferIn Vitro:Prolonged Expression and Induction of Macrophage Antimicrobial Activity

1996 • 17 citations

Localization of Inflammation and Virions in Canine Adenovirus Type 2 Bronchiolitis

1990 • 14 citations

Replication-incompetent herpesvirus vector delivery of an interferon alpha gene inhibits human immunodeficiency virus replication in human monocytes.

1993 • 12 citations

Micromethods for Analyzing Axon-Target Interactions in Vitro

1994 • 10 citations

The effects of cortisone treatment and burn injury on plasma and lung lavage cortisol concentrations and alveolar macrophage activity.

1981 • 9 citations

Murine Hypersensitivity Pneumonitis: Production and Importance of Colony-stimulating Factors in the Course of a Lung Inflammatory Reaction

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Effects of two adenoviruses (type 1 and type 8) on functional properties of bovine alveolar macrophages in vitro.

1992 • 6 citations

Effects of two adenoviruses (type 1 and type 8) on functional properties of bovine alveolar macrophages in vitro

1992 • 6 citations