The Rotterdam Study: 2010 objectives and design update
Data up to Jan 2025
Total Citations Per Year
Abstract
References (229)
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The Rotterdam Study: objectives and design update
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Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
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Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults
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Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study
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The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation
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Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study
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The assessment of vertebral deformity: A method for use in population studies and clinical trials
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Coronary Calcification Improves Cardiovascular Risk Prediction in the Elderly
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Ultrasound-Based Transient Elastography for the Detection of Hepatic Fibrosis: Systematic Review and Meta-analysis
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Are Retinal Arteriolar or Venular Diameters Associated with Markers for Cardiovascular Disorders? The Rotterdam Study
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Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration
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Prevalence of Parkinson's disease in the elderly
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Incidence of dementia: does gender make a difference?
2001 • 447 citations
Cerebral White Matter Lesions and Depressive Symptoms in Elderly Adults
2000 • 424 citations
Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study
2002 • 382 citations
Disagreement between subjective and actigraphic measures of sleep duration in a population‐based study of elderly persons*
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Incidence of parkinsonism and Parkinson disease in a general population
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Age-related Macular Degeneration Is Associated with Atherosclerosis
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Universal risk factors for multifactorial diseases
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Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly
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Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular Degeneration
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Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration
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A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels
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Genetic Risk of Age-related Maculopathy
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Retinal Vessel Diameters and Risk of Hypertension
2005 • 321 citations
Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to Osteoporotic Fracture: The Rotterdam Study
2005 • 320 citations
White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population
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Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study
2000 • 311 citations
The Incidence of Vertebral Fractures in Men and Women: The Rotterdam Study
2002 • 309 citations
Bone Density in Non-Insulin-Dependent Diabetes Mellitus: The Rotterdam Study
1995 • 308 citations
Differential Genetic Effects of <EMPH TYPE="ITAL">ESR1</EMPH> Gene Polymorphisms on Osteoporosis Outcomes
2004 • 294 citations
Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study
2003 • 285 citations
Retinal vessel diameters and risk of stroke
2006 • 266 citations
Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes
2007 • 259 citations
A new marker for osteoarthritis: Cross‐sectional and longitudinal approach
2004 • 257 citations
The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis
2006 • 251 citations
Antihypertensive drugs and incidence of dementia: the Rotterdam Study
2001 • 246 citations
A road map for efficient and reliable human genome epidemiology
2006 • 241 citations
Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study
2005 • 240 citations
The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
2007 • 240 citations
Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study
2003 • 238 citations
Estrogen Receptor α Gene Polymorphisms and Risk of Myocardial Infarction
2004 • 225 citations
Genetic Variants Associated With Cardiac Structure and Function
2009 • 225 citations
Thiazide Diuretics and the Risk for Hip Fracture
2003 • 219 citations
Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight
2002 • 211 citations
Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study
1996 • 204 citations
White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging
2008 • 202 citations
Cigarette smoking and risk of atrial fibrillation: The Rotterdam Study
2008 • 199 citations
Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk
2003 • 195 citations
Association of Nonsteroidal Anti-inflammatory Drugs With First Occurrence of Heart Failure and With Relapsing Heart Failure
2002 • 192 citations
Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study (HUNT 2)
2007 • 188 citations
Incidence and Recurrence of Late-Life Depression
2008 • 186 citations
Actigraphic sleep duration and fragmentation are related to obesity in the elderly: the Rotterdam Study
2008 • 184 citations
Relationship Between Atherosclerosis and Late-Life Depression
2004 • 183 citations
The Generation R Study: design and cohort update until the age of 4 years
2008 • 180 citations
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases
2007 • 179 citations
Incidence of Open-Angle Glaucoma in a General Elderly Population
2005 • 175 citations
Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study
2007 • 171 citations
Markers of Inflammation and Cellular Adhesion Molecules in Relation to Insulin Resistance in Nondiabetic Elderly: The Rotterdam Study
2001 • 171 citations
Corticosteroids and the Risk of Atrial Fibrillation
2006 • 167 citations
Incidence and risk factors of disability in the elderly: The Rotterdam Study
2006 • 158 citations
High-Normal Thyroid Function and Risk of Atrial Fibrillation
2008 • 158 citations
Salivary Cortisol Is Related to Atherosclerosis of Carotid Arteries
2008 • 155 citations
Endogenous Sex Hormones, Sex Hormone-Binding Globulin, and the Risk of Incident Vertebral Fractures in Elderly Men and Women: The Rotterdam Study
2004 • 148 citations
Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly
2009 • 148 citations
Cerebral Microbleeds: Accelerated 3D T2*-weighted GRE MR Imaging versus Conventional 2D T2*-weighted GRE MR Imaging for Detection
2008 • 147 citations
Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart Rate and Blood Pressure in β-Blocker Users
2008 • 140 citations
New times, new needs; e-epidemiology
2007 • 139 citations
Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study
2007 • 138 citations
Retinal Vessel Diameters and Risk of Impaired Fasting Glucose or Diabetes
2006 • 124 citations
Osteoporosis in Men and Women: A Story About Bone Mineral Density Thresholds and Hip Fracture Risk
2002 • 119 citations
Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid
2007 • 119 citations
Age-associated changes in ultrasound measurements of the calcaneus in men and women: The rotterdam study
1994 • 117 citations
Bone Mineral Density and the Risk of Peripheral Arterial Disease: The Rotterdam Study
2002 • 117 citations
Subclinical Atherosclerosis and Risk of Atrial Fibrillation
2007 • 117 citations
Cytochrome P450 2C9 *2 and *3 Polymorphisms and the Dose and Effect of Sulfonylurea in Type II Diabetes Mellitus
2007 • 115 citations
Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants
2007 • 110 citations
EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
2007 • 108 citations
Associations between overall physical activity level and cardiovascular risk factors in an adult population
2007 • 108 citations
Relationship between Refraction and Prevalent as well as Incident Age-Related Maculopathy: The Rotterdam Study
2003 • 103 citations
The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon
2003 • 102 citations
Determinants of locomotor disability in people aged 55 years and over: the Rotterdam Study.
2001 • 102 citations
Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K
2008 • 100 citations
Chronic obstructive pulmonary disease and mortality following hip fracture: a population-based cohort study
2007 • 100 citations
Validity of self-reported total physical activity questionnaire among older women
2008 • 100 citations
Validity and reliability of three definitions of hip osteoarthritis: cross sectional and longitudinal approach
2004 • 97 citations
Does hand osteoarthritis predict future hip or knee osteoarthritis?
2005 • 97 citations
Individual-level measures of social capital as predictors of all-cause and cardiovascular mortality: a population-based prospective study of men and women in Finland
2007 • 97 citations
The Female Advantage in Cardiovascular Disease: Do Vascular Beds Contribute Equally?
2007 • 95 citations
The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon
2004 • 93 citations
High Serum C-Reactive Protein Level Is Not an Independent Predictor for Stroke
2006 • 92 citations
Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration
2008 • 89 citations
Diabetes and modifiable risk factors for cardiovascular disease: the prospective Million Women Study
2008 • 87 citations
C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study
2006 • 87 citations
C-reactive protein is related to extent and progression of coronary and extra-coronary atherosclerosis; results from the Rotterdam study
2007 • 87 citations
Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement
2003 • 84 citations
Estrogen Receptor β (ESR2) Polymorphisms in Interaction With Estrogen Receptor α (ESR1) and Insulin-Like Growth Factor I (IGF1) Variants Influence the Risk of Fracture in Postmenopausal Women
2006 • 84 citations
Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: The Rotterdam Study
2005 • 83 citations
Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis?: The rotterdam study
2005 • 82 citations
Fractures as predictors of excess mortality in the aged—A population-based study with a 12-year follow-up
2008 • 81 citations
C-reactive Protein Level and Risk of Aging Macula Disorder
2007 • 79 citations
Overanticoagulation Associated with Combined Use of Antibacterial Drugs and Acenocoumarol or Phenprocoumon Anticoagulants
2002 • 78 citations
Bone mineral density and the risk of breast cancer: the Rotterdam Study
2003 • 76 citations
The Influence of an Insulin-Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study
2004 • 75 citations
Long Sleep Duration is Associated With Serum Cholesterol in the Elderly: The Rotterdam Study
2008 • 73 citations
HMG-CoA Reductase Inhibitors and the Risk of Vertebral Fracture
2004 • 73 citations
Role of radiography in predicting progression of osteoarthritis of the hip: prospective cohort study
2005 • 72 citations
The Paris prospective birth cohort study: Which design and who participates?
2007 • 72 citations
Genetic and environmental factors in familial clustering in physical activity
2008 • 71 citations
Sleep in Depression and Anxiety Disorders
2009 • 71 citations
Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry
2007 • 69 citations
The risk of overanticoagulation in patients with heart failure on coumarin anticoagulants
2004 • 68 citations
Associations of birth size and duration of breast feeding with cardiorespiratory fitness in childhood: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)
2008 • 68 citations
Derivation and validation of a mortality-risk index from a cohort of frail elderly patients hospitalised in medical wards via emergencies: the SAFES study
2008 • 67 citations
Depressive symptoms and risk of stroke: the Rotterdam Study
2008 • 66 citations
Cataract Surgery and the Risk of Aging Macula Disorder: The Rotterdam Study
2008 • 66 citations
The burden of mortality of obesity at middle and old age is small. A life table analysis of the US Health and Retirement Survey
2008 • 65 citations
Who are we missing? Area deprivation and survey participation
2008 • 65 citations
A Common Polymorphism in theCYP3A7Gene Is Associated with a Nearly 50% Reduction in Serum Dehydroepiandrosterone Sulfate Levels
2005 • 64 citations
Periodontal disease and risk of myocardial infarction: the role of gender and smoking
2007 • 64 citations
Patients with an ApoE &epsiv;4 allele require lower doses of coumarin anticoagulants
2005 • 63 citations
Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults
2008 • 62 citations
Electrocardiographic criteria of left ventricular hypertrophy in general population
2008 • 61 citations
Two short questionnaires on leisure-time physical activity compared with serum lipids, anthropometric measurements and aerobic power in a suburban population from Oslo, Norway
2007 • 61 citations
Geographic distribution of amyotrophic lateral sclerosis through motor neuron disease mortality data
2007 • 60 citations
Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort
2008 • 60 citations
Forty-year coronary mortality trends and changes in major risk factors in the first 10 years of follow-up in the seven countries study
2007 • 59 citations
Optimizing the design of web-based questionnaires – experience from a population-based study among 50,000 women
2007 • 58 citations
Polymorphisms in the Vascular Endothelial Growth Factor Gene and Risk of Age-related Macular Degeneration
2008 • 58 citations
C-Reactive Protein Levels, Haplotypes, and the Risk of Incident Chronic Obstructive Pulmonary Disease
2008 • 58 citations
Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation
2008 • 58 citations
Reduced pulmonary function is associated with lower levels of endogenous total and free testosterone. The Tromsø Study
2007 • 57 citations
Validity of the Framingham point scores in the elderly: Results from the Rotterdam study
2007 • 56 citations
Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or β-blockers
2007 • 55 citations
Inter-scan reproducibility of coronary calcium measurement using Multi Detector-Row Computed Tomography (MDCT)
2007 • 54 citations
Echocardiographic parameters and all-cause mortality: The Rotterdam Study
2008 • 53 citations
Assessment of fracture risk: Who should be treated for osteoporosis?
2005 • 52 citations
Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants
2005 • 52 citations
Loss of independence in Katz’s ADL ability in connection with an acute hospitalization: early clinical markers in French older people
2007 • 50 citations
Cardiovascular and respiratory hospitalizations and mortality among users of tiotropium in Denmark
2007 • 50 citations
Comparison of allergic diseases, symptoms and respiratory infections between Finnish and Russian school children
2008 • 48 citations
Clinically defined vascular depression in the general population
2006 • 46 citations
Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism and Aortic Calcification
2008 • 44 citations
Variations in estrogen receptor α gene and risk of dementia, and brain volumes on MRI
2004 • 42 citations
Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea
2008 • 41 citations
Mortality in patients with hypertension on angiotensin-I converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion polymorphism
2005 • 41 citations
Inflammation a possible link between economical stress and coronary heart disease
2007 • 40 citations
Comparison of the Danish Physical Activity Questionnaire with a validated position and motion instrument
2008 • 38 citations
Vitamin E and depressive symptoms are not related. The Rotterdam Study
2002 • 37 citations
Medication use and the risk of breast cancer
2007 • 37 citations
Lipoprotein-associated phospholipase A2 activity and risk of heart failure: the Rotterdam Study
2006 • 36 citations
Cardiovascular risk factors and mortality in patients with coronary heart disease
2008 • 36 citations
Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: The Erasmus Rucphen Family Study
2007 • 35 citations
The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study
2008 • 34 citations
Reproducibility of the past year and historical self-administered total physical activity questionnaire among older women
2007 • 34 citations
Factors associated with morbidity during the 2003 heat wave in two population-based cohorts of elderly subjects: PAQUID and Three City
2008 • 32 citations
Exercise participation and self-rated health: Do common genes explain the association?
2006 • 32 citations
Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe
2007 • 31 citations
Heterogeneity of the genetic risk in age-related macular disease
2005 • 30 citations
Airborne particulate matter and premature deaths in urban Europe: the new WHO guidelines and the challenge ahead as illustrated by Spain
2006 • 30 citations
Comparison of relative and attributable risk of myocardial infarction and stroke according to C-reactive protein and low-density lipoprotein cholesterol levels
2007 • 30 citations
Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study
2008 • 29 citations
Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study
2007 • 28 citations
Problems in using incidence to analyze risk factors in follow-up studies
2008 • 28 citations
The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure
2006 • 28 citations
Differences in precision in bone mineral density measured by SXA and DXA: the NOREPOS study
2008 • 26 citations
Survival of patients discharged after acute myocardial infarction and evidence-based drug therapy
2007 • 26 citations
Country of birth and survival after a first myocardial infarction in Stockholm, Sweden
2008 • 25 citations
Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants*
2002 • 25 citations
Sex differential in mortality trends of old-aged Danes: a nation wide study of age, period and cohort effects
2008 • 24 citations
Overanticoagulation associated with combined use of lactulose and acenocoumarol or phenprocoumon
2004 • 24 citations
The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9
2007 • 23 citations
A prospective study on the association between hay fever among children and incidence of asthma in East Germany
2007 • 22 citations
Bone mass density, subsequent risk of colon cancer and survival in postmenopausal women
2008 • 22 citations
Income and recurrent events after a coronary event in women
2008 • 20 citations
Is the time right for translation research in genomics?
2008 • 19 citations
Alcohol Consumption and Risk of Aging Macula Disorder in a General Population
2008 • 19 citations
Appropriate epidemiologic methods as a prerequisite for valid study results
2008 • 18 citations
Drug-Gene Interaction Between the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Antihypertensive Therapy
2006 • 18 citations
Diuretic–gene interaction and the risk of myocardial infarction and stroke
2006 • 16 citations
A method to predict the metabolic effects of changes in insulin treatment in subgroups of a large population based patient cohort
2007 • 16 citations
Genetic polymorphism of MTHFR G1793A in Chinese populations
2008 • 15 citations
Acute myocardial infarction incidence and hospital mortality: routinely collected national data versus linkage of national registers
2007 • 15 citations
AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families
2007 • 14 citations
Pharmacogenetic interactions of three candidate gene polymorphisms with ACE‐inhibitors or β‐blockers and the risk of atherosclerosis
2007 • 13 citations
Insertion/deletion gene polymorphism of the angiotensin-converting enzyme and blood pressure changes in older adults. The Rotterdam study
2007 • 12 citations
Can small changes in cardiovascular risk factors predict large future reductions in coronary heart disease mortality in Ireland?
2007 • 12 citations
Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea
2008 • 10 citations
Familial aggregation of forearm bone mineral density in Chinese
2007 • 5 citations
Can we learn more about the etiology of cardiovascular disease?
2007 • 2 citations