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The Rotterdam Study: 2010 objectives and design update

Data up to Jan 2025

Published2009
Citations239
References229

Total Citations Per Year

Abstract

References (229)

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Body mass index as a predictor of fracture risk: A meta-analysis

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Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study

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The Rotterdam Study: objectives and design update

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Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

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Subclinical Hypothyroidism Is an Independent Risk Factor for Atherosclerosis and Myocardial Infarction in Elderly Women: The Rotterdam Study

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Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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Dietary Intake of Antioxidants and Risk of Alzheimer Disease

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Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study.

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Age-Specific Prevalence and Causes of Blindness and Visual Impairment in an Older Population

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Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

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The Prevalence of Age-related Maculopathy in the Rotterdam Study

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Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults

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Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study

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The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation

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Prevalence and risk factors of cerebral microbleeds

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Predictive Value of Noninvasive Measures of Atherosclerosis for Incident Myocardial Infarction

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Alcohol consumption and risk of dementia: the Rotterdam Study

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Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study

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Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study.

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Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam study

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The assessment of vertebral deformity: A method for use in population studies and clinical trials

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Coronary Calcification Improves Cardiovascular Risk Prediction in the Elderly

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Ultrasound-Based Transient Elastography for the Detection of Hepatic Fibrosis: Systematic Review and Meta-analysis

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Are Retinal Arteriolar or Venular Diameters Associated with Markers for Cardiovascular Disorders? The Rotterdam Study

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Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration

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Prevalence of Parkinson's disease in the elderly

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Incidence of dementia: does gender make a difference?

2001 • 447 citations

Cerebral White Matter Lesions and Depressive Symptoms in Elderly Adults

2000 • 424 citations

Vitamin B12, Folate, and Homocysteine in Depression: The Rotterdam Study

2002 • 382 citations

Disagreement between subjective and actigraphic measures of sleep duration in a population‐based study of elderly persons*

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Incidence of parkinsonism and Parkinson disease in a general population

2004 • 360 citations

Age-related Macular Degeneration Is Associated with Atherosclerosis

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Universal risk factors for multifactorial diseases

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Carotid Plaques Increase the Risk of Stroke and Subtypes of Cerebral Infarction in Asymptomatic Elderly

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Complement Factor H Polymorphism, Complement Activators, and Risk of Age-Related Macular Degeneration

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Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration

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A Polymorphism in the Glucocorticoid Receptor Gene, Which Decreases Sensitivity to Glucocorticoids In Vivo, Is Associated With Low Insulin and Cholesterol Levels

2002 • 325 citations

Genetic Risk of Age-related Maculopathy

1998 • 323 citations

Retinal Vessel Diameters and Risk of Hypertension

2005 • 321 citations

Promoter and 3′-Untranslated-Region Haplotypes in the Vitamin D Receptor Gene Predispose to Osteoporotic Fracture: The Rotterdam Study

2005 • 320 citations

White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population

2009 • 317 citations

Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study

2000 • 311 citations

The Incidence of Vertebral Fractures in Men and Women: The Rotterdam Study

2002 • 309 citations

Bone Density in Non-Insulin-Dependent Diabetes Mellitus: The Rotterdam Study

1995 • 308 citations

Differential Genetic Effects of <EMPH TYPE="ITAL">ESR1</EMPH> Gene Polymorphisms on Osteoporosis Outcomes

2004 • 294 citations

Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study

2003 • 285 citations

Retinal vessel diameters and risk of stroke

2006 • 266 citations

Genetic Variation, C-Reactive Protein Levels, and Incidence of Diabetes

2007 • 259 citations

A new marker for osteoarthritis: Cross‐sectional and longitudinal approach

2004 • 257 citations

The Association between Common Vitamin D Receptor Gene Variations and Osteoporosis: A Participant-Level Meta-Analysis

2006 • 251 citations

Antihypertensive drugs and incidence of dementia: the Rotterdam Study

2001 • 246 citations

A road map for efficient and reliable human genome epidemiology

2006 • 241 citations

Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study

2005 • 240 citations

The Generation R Study Biobank: a resource for epidemiological studies in children and their parents

2007 • 240 citations

Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study

2003 • 238 citations

Estrogen Receptor α Gene Polymorphisms and Risk of Myocardial Infarction

2004 • 225 citations

Genetic Variants Associated With Cardiac Structure and Function

2009 • 225 citations

Thiazide Diuretics and the Risk for Hip Fracture

2003 • 219 citations

Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight

2002 • 211 citations

Case-control analysis of bone resorption markers, disability, and hip fracture risk: the Rotterdam study

1996 • 204 citations

White matter atrophy and lesion formation explain the loss of structural integrity of white matter in aging

2008 • 202 citations

Cigarette smoking and risk of atrial fibrillation: The Rotterdam Study

2008 • 199 citations

Association of 5' estrogen receptor alpha gene polymorphisms with bone mineral density, vertebral bone area and fracture risk

2003 • 195 citations

Association of Nonsteroidal Anti-inflammatory Drugs With First Occurrence of Heart Failure and With Relapsing Heart Failure

2002 • 192 citations

Reliability and validity of self-reported physical activity in the Nord-Trøndelag Health Study (HUNT 2)

2007 • 188 citations

Incidence and Recurrence of Late-Life Depression

2008 • 186 citations

Actigraphic sleep duration and fragmentation are related to obesity in the elderly: the Rotterdam Study

2008 • 184 citations

Relationship Between Atherosclerosis and Late-Life Depression

2004 • 183 citations

The Generation R Study: design and cohort update until the age of 4 years

2008 • 180 citations

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

2007 • 179 citations

Incidence of Open-Angle Glaucoma in a General Elderly Population

2005 • 175 citations

Sodium and potassium intake and risk of cardiovascular events and all-cause mortality: the Rotterdam Study

2007 • 171 citations

Markers of Inflammation and Cellular Adhesion Molecules in Relation to Insulin Resistance in Nondiabetic Elderly: The Rotterdam Study

2001 • 171 citations

Corticosteroids and the Risk of Atrial Fibrillation

2006 • 167 citations

Incidence and risk factors of disability in the elderly: The Rotterdam Study

2006 • 158 citations

High-Normal Thyroid Function and Risk of Atrial Fibrillation

2008 • 158 citations

Salivary Cortisol Is Related to Atherosclerosis of Carotid Arteries

2008 • 155 citations

Endogenous Sex Hormones, Sex Hormone-Binding Globulin, and the Risk of Incident Vertebral Fractures in Elderly Men and Women: The Rotterdam Study

2004 • 148 citations

Prevalence, Incidence, and Lifetime Risk for the Development of COPD in the Elderly

2009 • 148 citations

Cerebral Microbleeds: Accelerated 3D T2*-weighted GRE MR Imaging versus Conventional 2D T2*-weighted GRE MR Imaging for Detection

2008 • 147 citations

Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart Rate and Blood Pressure in β-Blocker Users

2008 • 140 citations

New times, new needs; e-epidemiology

2007 • 139 citations

Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study

2007 • 138 citations

Retinal Vessel Diameters and Risk of Impaired Fasting Glucose or Diabetes

2006 • 124 citations

Osteoporosis in Men and Women: A Story About Bone Mineral Density Thresholds and Hip Fracture Risk

2002 • 119 citations

Rapid declines in coronary heart disease mortality in Eastern Europe are associated with increased consumption of oils rich in alpha-linolenic acid

2007 • 119 citations

Age-associated changes in ultrasound measurements of the calcaneus in men and women: The rotterdam study

1994 • 117 citations

Bone Mineral Density and the Risk of Peripheral Arterial Disease: The Rotterdam Study

2002 • 117 citations

Subclinical Atherosclerosis and Risk of Atrial Fibrillation

2007 • 117 citations

Cytochrome P450 2C9 *2 and *3 Polymorphisms and the Dose and Effect of Sulfonylurea in Type II Diabetes Mellitus

2007 • 115 citations

Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants

2007 • 110 citations

EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries

2007 • 108 citations

Associations between overall physical activity level and cardiovascular risk factors in an adult population

2007 • 108 citations

Relationship between Refraction and Prevalent as well as Incident Age-Related Maculopathy: The Rotterdam Study

2003 • 103 citations

The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon

2003 • 102 citations

Determinants of locomotor disability in people aged 55 years and over: the Rotterdam Study.

2001 • 102 citations

Association of hip fracture incidence and intake of calcium, magnesium, vitamin D, and vitamin K

2008 • 100 citations

Chronic obstructive pulmonary disease and mortality following hip fracture: a population-based cohort study

2007 • 100 citations

Validity of self-reported total physical activity questionnaire among older women

2008 • 100 citations

Validity and reliability of three definitions of hip osteoarthritis: cross sectional and longitudinal approach

2004 • 97 citations

Does hand osteoarthritis predict future hip or knee osteoarthritis?

2005 • 97 citations

Individual-level measures of social capital as predictors of all-cause and cardiovascular mortality: a population-based prospective study of men and women in Finland

2007 • 97 citations

The Female Advantage in Cardiovascular Disease: Do Vascular Beds Contribute Equally?

2007 • 95 citations

The risk of bleeding complications in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon

2004 • 93 citations

High Serum C-Reactive Protein Level Is Not an Independent Predictor for Stroke

2006 • 92 citations

Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration

2008 • 89 citations

Diabetes and modifiable risk factors for cardiovascular disease: the prospective Million Women Study

2008 • 87 citations

C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study

2006 • 87 citations

C-reactive protein is related to extent and progression of coronary and extra-coronary atherosclerosis; results from the Rotterdam study

2007 • 87 citations

Cholesterol lowering drugs and risk of age related maculopathy: prospective cohort study with cumulative exposure measurement

2003 • 84 citations

Estrogen Receptor β (ESR2) Polymorphisms in Interaction With Estrogen Receptor α (ESR1) and Insulin-Like Growth Factor I (IGF1) Variants Influence the Risk of Fracture in Postmenopausal Women

2006 • 84 citations

Bone mineral density and vertebral fracture history are associated with incident and progressive radiographic knee osteoarthritis in elderly men and women: The Rotterdam Study

2005 • 83 citations

Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis?: The rotterdam study

2005 • 82 citations

Fractures as predictors of excess mortality in the aged—A population-based study with a 12-year follow-up

2008 • 81 citations

C-reactive Protein Level and Risk of Aging Macula Disorder

2007 • 79 citations

Overanticoagulation Associated with Combined Use of Antibacterial Drugs and Acenocoumarol or Phenprocoumon Anticoagulants

2002 • 78 citations

Bone mineral density and the risk of breast cancer: the Rotterdam Study

2003 • 76 citations

The Influence of an Insulin-Like Growth Factor I Gene Promoter Polymorphism on Hip Bone Geometry and the Risk of Nonvertebral Fracture in the Elderly: The Rotterdam Study

2004 • 75 citations

Long Sleep Duration is Associated With Serum Cholesterol in the Elderly: The Rotterdam Study

2008 • 73 citations

HMG-CoA Reductase Inhibitors and the Risk of Vertebral Fracture

2004 • 73 citations

Role of radiography in predicting progression of osteoarthritis of the hip: prospective cohort study

2005 • 72 citations

The Paris prospective birth cohort study: Which design and who participates?

2007 • 72 citations

Genetic and environmental factors in familial clustering in physical activity

2008 • 71 citations

Sleep in Depression and Anxiety Disorders

2009 • 71 citations

Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registry

2007 • 69 citations

The risk of overanticoagulation in patients with heart failure on coumarin anticoagulants

2004 • 68 citations

Associations of birth size and duration of breast feeding with cardiorespiratory fitness in childhood: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC)

2008 • 68 citations

Derivation and validation of a mortality-risk index from a cohort of frail elderly patients hospitalised in medical wards via emergencies: the SAFES study

2008 • 67 citations

Depressive symptoms and risk of stroke: the Rotterdam Study

2008 • 66 citations

Cataract Surgery and the Risk of Aging Macula Disorder: The Rotterdam Study

2008 • 66 citations

The burden of mortality of obesity at middle and old age is small. A life table analysis of the US Health and Retirement Survey

2008 • 65 citations

Who are we missing? Area deprivation and survey participation

2008 • 65 citations

A Common Polymorphism in theCYP3A7Gene Is Associated with a Nearly 50% Reduction in Serum Dehydroepiandrosterone Sulfate Levels

2005 • 64 citations

Periodontal disease and risk of myocardial infarction: the role of gender and smoking

2007 • 64 citations

Patients with an ApoE ϵ4 allele require lower doses of coumarin anticoagulants

2005 • 63 citations

Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults

2008 • 62 citations

Electrocardiographic criteria of left ventricular hypertrophy in general population

2008 • 61 citations

Two short questionnaires on leisure-time physical activity compared with serum lipids, anthropometric measurements and aerobic power in a suburban population from Oslo, Norway

2007 • 61 citations

Geographic distribution of amyotrophic lateral sclerosis through motor neuron disease mortality data

2007 • 60 citations

Occupational social class, risk factors and cardiovascular disease incidence in men and women: a prospective study in the European Prospective Investigation of Cancer and Nutrition in Norfolk (EPIC-Norfolk) cohort

2008 • 60 citations

Forty-year coronary mortality trends and changes in major risk factors in the first 10 years of follow-up in the seven countries study

2007 • 59 citations

Optimizing the design of web-based questionnaires – experience from a population-based study among 50,000 women

2007 • 58 citations

Polymorphisms in the Vascular Endothelial Growth Factor Gene and Risk of Age-related Macular Degeneration

2008 • 58 citations

C-Reactive Protein Levels, Haplotypes, and the Risk of Incident Chronic Obstructive Pulmonary Disease

2008 • 58 citations

Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation

2008 • 58 citations

Reduced pulmonary function is associated with lower levels of endogenous total and free testosterone. The Tromsø Study

2007 • 57 citations

Validity of the Framingham point scores in the elderly: Results from the Rotterdam study

2007 • 56 citations

Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or β-blockers

2007 • 55 citations

Inter-scan reproducibility of coronary calcium measurement using Multi Detector-Row Computed Tomography (MDCT)

2007 • 54 citations

Echocardiographic parameters and all-cause mortality: The Rotterdam Study

2008 • 53 citations

Assessment of fracture risk: Who should be treated for osteoporosis?

2005 • 52 citations

Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants

2005 • 52 citations

Loss of independence in Katz’s ADL ability in connection with an acute hospitalization: early clinical markers in French older people

2007 • 50 citations

Cardiovascular and respiratory hospitalizations and mortality among users of tiotropium in Denmark

2007 • 50 citations

Comparison of allergic diseases, symptoms and respiratory infections between Finnish and Russian school children

2008 • 48 citations

Clinically defined vascular depression in the general population

2006 • 46 citations

Vitamin K Epoxide Reductase Complex Subunit 1 (VKORC1) Polymorphism and Aortic Calcification

2008 • 44 citations

Variations in estrogen receptor α gene and risk of dementia, and brain volumes on MRI

2004 • 42 citations

Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea

2008 • 41 citations

Mortality in patients with hypertension on angiotensin-I converting enzyme (ACE)-inhibitor treatment is influenced by the ACE insertion/deletion polymorphism

2005 • 41 citations

Inflammation a possible link between economical stress and coronary heart disease

2007 • 40 citations

Comparison of the Danish Physical Activity Questionnaire with a validated position and motion instrument

2008 • 38 citations

Vitamin E and depressive symptoms are not related. The Rotterdam Study

2002 • 37 citations

Medication use and the risk of breast cancer

2007 • 37 citations

Lipoprotein-associated phospholipase A2 activity and risk of heart failure: the Rotterdam Study

2006 • 36 citations

Cardiovascular risk factors and mortality in patients with coronary heart disease

2008 • 36 citations

Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: The Erasmus Rucphen Family Study

2007 • 35 citations

The effect of catechol-O-methyltransferase Met/Val functional polymorphism on smoking cessation: retrospective and prospective analyses in a cohort study

2008 • 34 citations

Reproducibility of the past year and historical self-administered total physical activity questionnaire among older women

2007 • 34 citations

Factors associated with morbidity during the 2003 heat wave in two population-based cohorts of elderly subjects: PAQUID and Three City

2008 • 32 citations

Exercise participation and self-rated health: Do common genes explain the association?

2006 • 32 citations

Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe

2007 • 31 citations

Heterogeneity of the genetic risk in age-related macular disease

2005 • 30 citations

Airborne particulate matter and premature deaths in urban Europe: the new WHO guidelines and the challenge ahead as illustrated by Spain

2006 • 30 citations

Comparison of relative and attributable risk of myocardial infarction and stroke according to C-reactive protein and low-density lipoprotein cholesterol levels

2007 • 30 citations

Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study

2008 • 29 citations

Timing of blood extraction in epidemiologic and proteomic studies: results and proposals from the PANKRAS II Study

2007 • 28 citations

Problems in using incidence to analyze risk factors in follow-up studies

2008 • 28 citations

The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure

2006 • 28 citations

Differences in precision in bone mineral density measured by SXA and DXA: the NOREPOS study

2008 • 26 citations

Survival of patients discharged after acute myocardial infarction and evidence-based drug therapy

2007 • 26 citations

Country of birth and survival after a first myocardial infarction in Stockholm, Sweden

2008 • 25 citations

Overanticoagulation associated with combined use of antifungal agents and coumarin anticoagulants*

2002 • 25 citations

Sex differential in mortality trends of old-aged Danes: a nation wide study of age, period and cohort effects

2008 • 24 citations

Overanticoagulation associated with combined use of lactulose and acenocoumarol or phenprocoumon

2004 • 24 citations

The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9

2007 • 23 citations

A prospective study on the association between hay fever among children and incidence of asthma in East Germany

2007 • 22 citations

Bone mass density, subsequent risk of colon cancer and survival in postmenopausal women

2008 • 22 citations

Income and recurrent events after a coronary event in women

2008 • 20 citations

Is the time right for translation research in genomics?

2008 • 19 citations

Alcohol Consumption and Risk of Aging Macula Disorder in a General Population

2008 • 19 citations

Appropriate epidemiologic methods as a prerequisite for valid study results

2008 • 18 citations

Drug-Gene Interaction Between the Insertion/Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Antihypertensive Therapy

2006 • 18 citations

Diuretic–gene interaction and the risk of myocardial infarction and stroke

2006 • 16 citations

A method to predict the metabolic effects of changes in insulin treatment in subgroups of a large population based patient cohort

2007 • 16 citations

Genetic polymorphism of MTHFR G1793A in Chinese populations

2008 • 15 citations

Acute myocardial infarction incidence and hospital mortality: routinely collected national data versus linkage of national registers

2007 • 15 citations

AHSG gene polymorphisms are associated with bone mineral density in Caucasian nuclear families

2007 • 14 citations

Pharmacogenetic interactions of three candidate gene polymorphisms with ACE‐inhibitors or β‐blockers and the risk of atherosclerosis

2007 • 13 citations

Insertion/deletion gene polymorphism of the angiotensin-converting enzyme and blood pressure changes in older adults. The Rotterdam study

2007 • 12 citations

Can small changes in cardiovascular risk factors predict large future reductions in coronary heart disease mortality in Ireland?

2007 • 12 citations

Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea

2008 • 10 citations

Familial aggregation of forearm bone mineral density in Chinese

2007 • 5 citations

Can we learn more about the etiology of cardiovascular disease?

2007 • 2 citations

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