Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation

Markers of Inflammation and Cardiovascular Disease

2003 • 6,067 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

2003 • 4,975 citations

C-reactive protein: a critical update

2003 • 3,447 citations

C-reactive protein: a critical update

2003 • 3,027 citations

C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease

2004 • 2,914 citations

Plasma Triglyceride Level is a Risk Factor for Cardiovascular Disease Independent of High-Density Lipoprotein Cholesterol Level: A Metaanalysis of Population-Based Prospective Studies

1996 • 2,037 citations

Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses

2000 • 1,703 citations

Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies

1996 • 1,658 citations

Effect of Statin Therapy on C-Reactive Protein Levels

2001 • 1,627 citations

Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study

1996 • 1,106 citations

A Self-Fulfilling Prophecy

2002 • 1,039 citations

MARKERS OF INFLAMMATION AND CARDIOVASCULAR DISEASE

2003 • 1,029 citations

Lipoprotein(a) and Coronary Heart Disease

2000 • 945 citations

Mendelian randomization as an instrumental variable approach to causal inference

2007 • 851 citations

Targeting C-reactive protein for the treatment of cardiovascular disease

2006 • 659 citations

Homocysteine and stroke: evidence on a causal link from mendelian randomisation

2005 • 394 citations

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study

2005 • 332 citations

Human CRP Gene Polymorphism Influences CRP Levels

2003 • 304 citations

Association of Polymorphisms in the CRP Gene With Circulating C-Reactive Protein Levels and Cardiovascular Events

2006 • 265 citations

A road map for efficient and reliable human genome epidemiology

2006 • 241 citations

C-Reactive Protein and Risk of Cardiovascular Disease in Men and Women From the Framingham Heart Study

2005 • 241 citations

C-reactive protein in atherosclerosis: A causal factor?

2006 • 213 citations

Vascular smooth muscle cell activation by C-reactive protein

2003 • 212 citations

C-reactive protein comes of age

2005 • 211 citations

Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis

2002 • 210 citations

Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

2008 • 187 citations

The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases

2007 • 179 citations

Insight into the nature of the CRP–coronary event association using Mendelian randomization

2006 • 170 citations

C-Reactive Protein–Induced In Vitro Endothelial Cell Activation Is an Artefact Caused by Azide and Lipopolysaccharide

2005 • 160 citations

Genetic Variation Is Associated With C-Reactive Protein Levels in the Third National Health and Nutrition Examination Survey

2006 • 145 citations

Proinflammatory Effects of Bacterial Recombinant Human C-Reactive Protein Are Caused by Contamination With Bacterial Products, Not by C-Reactive Protein Itself

2005 • 134 citations

Interleukin-6, Fibrin D-Dimer, and Coagulation Factors VII and XIIa in Prediction of Coronary Heart Disease

2004 • 126 citations

The Emergence of Networks in Human Genome Epidemiology

2006 • 92 citations

C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study

2006 • 87 citations

C-Reactive Protein (CRP) Gene Polymorphisms, CRP Levels, and Risk of Incident Coronary Heart Disease in Two Nested Case-Control Studies

2008 • 86 citations

Estimation of Bias in Nongenetic Observational Studies Using “Mendelian Triangulation”

2006 • 77 citations

Bayesian Meta-Analysis of Genetic Association Studies with Different Sets of Markers

2008 • 60 citations

Genetic epidemiological studies of coronary heart disease

2002 • 56 citations