Vitamin neurotoxicity

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

1986 • 2,428 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Retinoic Acid Embryopathy

1985 • 1,921 citations

Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage

1988 • 1,745 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1991 • 1,298 citations

The HL-60 promyelocytic leukemia cell line: proliferation, differentiation, and cellular oncogene expression

1987 • 1,180 citations

Retinoic acid causes an anteroposterior transformation in the developing central nervous system

1989 • 885 citations

The Vitamin D Endocrine System: Steroid Metabolism, Hormone Receptors, and Biological Response (Calcium Binding Proteins)*

1982 • 698 citations

Sensory Neuropathy from Pyridoxine Abuse

1983 • 695 citations

Transport and Storage of Vitamin A

1990 • 618 citations

The Biochemical Functions of Ascorbic Acid

1986 • 540 citations

Association of the Ah receptor with the 90-kDa heat shock protein.

1988 • 511 citations

1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.

1991 • 475 citations

VITAMIN K-DEPENDENT CARBOXYLASE

1985 • 466 citations

Wernicke's Encephalopathy

1985 • 428 citations

Evaluation of vitamin A toxicity

1990 • 363 citations

Dietary folate as a risk factor for neural‐tube defects: evidence from a case‐control study in Western Australia

1989 • 353 citations

Cellular functions of ascorbic acid

1990 • 348 citations

DATATOP: A Multicenter Controlled Clinical Trial in Early Parkinson's Disease

1989 • 337 citations

Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells.

1991 • 328 citations

Vitamin A Transport in Human Vitamin A Toxicity

1976 • 325 citations

Excessive Intake of Vitamin A as a Cause of Congenital Anomalies in the Rat

1953 • 323 citations

γ-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase

1990 • 312 citations

Retinal photoreceptor-pigment epithelium interactions. Friedenwald lecture.

1985 • 291 citations

Neurologic sequelae of methotrexate and ionizing radiation: a new classification.

1981 • 271 citations

Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.

1983 • 266 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects

1989 • 256 citations

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

1991 • 253 citations

Assay Using Brain Homogenate for Measuring the Antioxidant Activity of Biological Fluids

1974 • 243 citations

Retinoid requirements for recovery of sensitivity after visual-pigment bleaching in isolated photoreceptors.

1989 • 241 citations

Safety of vitamin A

1989 • 239 citations

Sensory neuropathy with low‐dose pyridoxine

1985 • 209 citations

Calmodulin-stimulated dephosphorylation of p-nitrophenyl phosphate and free phosphotyrosine by calcineurin.

1983 • 198 citations

Nonenzymatic Covalent Posttranslational Modification of Proteins In Vivo

1985 • 197 citations

Evolution and the Need for Ascorbic Acid

1970 • 184 citations

Characterization of "Peak E," a Novel Amino Acid Associated with Eosinophilia-Myalgia Syndrome

1990 • 182 citations

Adverse reactions to isotretinoin

1988 • 181 citations

Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus

1990 • 180 citations

Transport of ascorbic acid and other water-soluble vitamins

1988 • 179 citations

Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate

1990 • 176 citations

Vitamin Homeostasis in the Central Nervous System

1977 • 170 citations

In vitro oxidation of ascorbic acid and its prevention by GSH

1987 • 170 citations

Vitamin E inhibits protein kinase c activity

1988 • 169 citations

Vitamin A and the role of the pigment epithelium during bleaching and regeneration of rhodopsin in the frog eye

1976 • 166 citations

Reaction of ascorbate with lysine and protein under autoxidizing conditions: formation of N.epsilon.-(carboxymethyl)lysine by reaction between lysine and products of autoxidation of ascorbate

1990 • 164 citations

Protein Modification in Aging

1988 • 160 citations

Interaction of folylpolyglutamates with enzymes in one-carbon metabolism

1989 • 153 citations

A toxicity study of parenteral thiamine hydrochloride

1989 • 140 citations

Clinical, genetic, and epidemiological factors in neural tube defects.

1988 • 139 citations

Transcriptional regulation of the glucokinase gene by biotin in starved rats

1991 • 134 citations

Pseudotumor Cerebri

1982 • 125 citations

Recommendations for vitamin A use during pregnancy

1987 • 123 citations

Restricted Transport of Vitamin D and A Derivatives Through the Rat Blood‐Brain Barrier

1985 • 121 citations

Physiological occurrence, biosynthesis and metabolism of retinoic acid: evidence for roles of Cellular Retinol-Binding Protein (CRBP) and Cellular Retinoic Acid-Binding Protein (CRABP) in the pathway of retinoic acid homeostasis

1991 • 120 citations

Differential regulation of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase.

1985 • 115 citations

Determination of the active portion of the folic acid molecule in cellular slime mold chemotaxis

1975 • 115 citations

Mechanism of Vitamin A Movement between Rod Outer Segments, Interphotoreceptor Retinoid-binding Protein, and Liposomes

1989 • 114 citations

THE DIABETOGENIC EFFECT OF DEHYDROASCORBIC AND DEHYDROISOASCORBIC ACIDS

1950 • 113 citations

Regional differences in extracellular ascorbic acid levels in the rat brain determined by high speed cyclic voltammetry

1984 • 112 citations

Severe hypervitaminosis A in siblings: Evidence of variable tolerance to retinol intake

1987 • 109 citations

Vitamin B₆ in Clinical Neurology

1990 • 107 citations

Interphotoreceptor retinoid-binding protein promotes rhodopsin regeneration in toad photoreceptors.

1990 • 104 citations

Dose‐dependent expression of neuronopathy after experimental pyridoxine intoxication

1989 • 100 citations

Controlled trial of vitamin-mineral supplementation: Effects of intelligence and performance

1991 • 99 citations

Perspective on Vitamin E as Therapy

1981 • 96 citations

A Ca2+ transport system associated with the plasma membrane of Dictyostelium discoideum is activated by different chemoattractant receptors.

1991 • 94 citations

Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90

1991 • 91 citations

Membrane effects of retinoids: Possible correlation with toxicity

1981 • 90 citations

Membrane phospholipids as an energy source in the operation of the visual cycle

1991 • 85 citations

Sequence analysis, cellular localization, and expression of a neuroretina adhesion and cell survival molecule

1987 • 83 citations

Decreased [3H]serotonin and [3H]spiperone binding consequent to lipid peroxidation in rat cortical membranes

1982 • 81 citations

Increased extracellular levels of ascorbate in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis

1988 • 78 citations

Maternal vitamin A supplementation in relation to selected birth defects

1990 • 77 citations

Ascorbic acid could be hazardous to your experiments: A commentary on dopamine receptor binding studies with speculation on a role for ascorbic acid in neuronal function

1983 • 74 citations

Role of folate binding proteins in folate metabolism.

1989 • 73 citations

Pyridoxine reversal of L-dopa effects in Parkinsonism.

1969 • 70 citations

Vitamin D ? Soltriol The heliogenic steroid hormone: Somatotrophic activator and modulator

1988 • 70 citations

Biotin

1989 • 70 citations

Inhibitory effects of pyridoxal phosphate, ascorbate and aminoguanidine on nonenzymatic glycosylation

1988 • 68 citations

Treatment of Massive Intrathecal Methotrexate Overdose by Ventriculolumbar Perfusion

1984 • 67 citations

Rapid changes in striatal ascorbate in response to tail-pinch monitored by constant potential voltammetry

1989 • 67 citations

Immunosuppressive activity of 13-cis-retinoic acid and prevention of experimental autoimmune encephalomyelitis in rats.

1991 • 66 citations

Controlled Trial of Pyridoxine in the Premenstrual Syndrome

1985 • 65 citations

[13] Preparation and properties of hemoglobin modified with derivatives of pyridoxal

1981 • 63 citations

Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics

1975 • 62 citations

Protracted Hypervitaminosis A Following Long-term, Low-Level Intake

1982 • 61 citations

Pharmacokinetics and biochemical effects of a fatal intrathecal methotrexate overdose

1982 • 59 citations

The role of hemoglobin in the etiology of cerebral vasospasm

1983 • 58 citations

Proliferation of glial‐derived cells in defined media

1982 • 57 citations

A possible etiological role for ascorbate in calculi formation.

1986 • 57 citations

ACUTE HYPERVITAMINOSIS A OF THE INFANT<subtitle>Its Clinical Manifestation with Benign Acute Hydrocephalus and Pronounced Bulge of the Fontanel; a Clinical and Biologic Study</subtitle>

1954 • 57 citations

Chronic Vitamin A Intoxication in Infants Fed Chicken Liver

1980 • 55 citations

Lessons From the E-Ferol Tragedy

1986 • 54 citations

A possible etiological role for ascorbate in calculi formation.

1986 • 54 citations

Vitamin B6 influences glucocorticoid receptor-dependent gene expression.

1990 • 54 citations

Subacute toxicity of pyridoxine hydrochloride in the beagle dog

1978 • 54 citations

1 alpha,25-dihydroxyvitamin D3-induced regulation of protein kinase C gene expression during HL-60 cell differentiation.

1991 • 53 citations

Biosynthesis of 11-cis-retinoids and retinyl esters by bovine pigment epithelium membranes

1987 • 53 citations

Pharmacokinetics and biochemical effects of a fatal intrathecal methotrexate overdose

1982 • 52 citations

Modulation of neostriatal activity by iontophoresis of ascorbic acid

1985 • 52 citations

Reversible Binding of the Chemoattractant Folic Acid to Cells of Dictyostelium discoideum

1980 • 52 citations

Intrastriatal folic acid mimics the distant but not local brain damaging properties of kainic acid

1981 • 52 citations

Mortality among health-conscious elderly Californians.

1982 • 51 citations

Ascorbic acid levels in mammalian tissues and its metabolic significance

1972 • 50 citations

PROVOCATION OF CEREBRAL SEIZURES BY DERANGEMENT OF THE NATURAL BALANCE BETWEEN GLUTAMIC ACID AND γ‐AMINOBUTYRIC ACID

1966 • 50 citations

Modification of iron uptake and lipid peroxidation by hypoxia, ascorbic acid, and alpha-tocopherol in iron-loaded rat myocardial cell cultures.

1987 • 48 citations

An evaluation of the anticonvulsant effects of vitamin E

1990 • 48 citations

EXPERIMENTAL STUDY OF THE EFFECTS PRODUCED BY LARGE DOSES OF VITAMIN B6

1942 • 46 citations

Multiple Comparisons Emphasizing Selected Contrasts: An Extension and Generalization of Dunnett's Procedure

1977 • 45 citations

Substrate requirement and media supplements necessary for the long-term survival of chick sympathetic and sensory neurons cultured without serum

1982 • 45 citations

Changes in the intracellular levels of pyridoxal 5′-phosphate affect the induction of tyrosine aminotransferase by glucocorticoids

1981 • 44 citations

The effect of glutathione and vitamins A, C, and E on acute skin flap survival

1987 • 43 citations

High Pyridoxine Diet in the Rat: Possible Implications for Megavitamin Therapy

1973 • 43 citations

SPECTROFLUORIMETRIC ASSAY OF VITAMIN B₆ ANALOGUES IN BRAIN TISSUE

1969 • 43 citations

γ‐Aminobutyric Acid Stimulates the Release of Endogenous Ascorbic Acid from Rat Striatal Tissue

1984 • 42 citations

Circadian changes in extracellular ascorbate in rat cortex, accumbens, striatum and hippocampus: Correlations with motor activity

1985 • 41 citations

Micronutrients and Susceptibility to Infection

1990 • 40 citations

Suppression of the Cerebral Vasospastic Actions of Oxyhemoglobin by Ascorbic Acid

1991 • 39 citations

Lessons from the E-Ferol tragedy.

1986 • 38 citations

Association between the expression of the c-myc oncogene mRNA and the expression of the receptor protein for 1,25-dihydroxyvitamin D3.

1987 • 37 citations

On the Mechanism of Pyridoxine Responsive Homocystinuria. II. Properties of Normal and Mutant Cystathionine β-Synthase from Cultured Fibroblasts

1974 • 37 citations

Recent progress in vitamin A research: nuclear retinoic acid receptors and their interaction with gene elements

1990 • 36 citations

Pharmacology of Antineoplastic Agents in Cerebrospinal Fluid

1980 • 35 citations

Disposition of 13-cis-retinoic acid and N-(2-hydroxyethyl)retinamide in mice after oral doses.

1982 • 35 citations

Retinoid metabolism in cultured human retinal pigment epithelium

1988 • 35 citations

Suppression of the cerebral vasospastic actions of oxyhemoglobin by ascorbic acid

1991 • 34 citations

The distribution and chemical nature of radioactive folates in rat liver cells and rat liver mitochondria

1979 • 33 citations

Thiamin-responsive maple-syrup-urine disease: decreased affinity of the mutant branched-chain alpha-keto acid dehydrogenase for alpha-ketoisovalerate and thiamin pyrophosphate.

1982 • 33 citations

Lack of Difference Between Retinoic Acid and Retinol in Stimulating Progesterone Production by Luteinizing Granulosa Cellsin Vitro

1987 • 33 citations

Incorporation of retinoic acid into proteins via retinoyl-CoA

1989 • 33 citations

Guanine nucleotides modulate the ligand binding properties of cell surface folate receptors in Dictyostelium discoideum

1985 • 29 citations

The influence of folic acid on the frequency of epileptic attacks

1981 • 29 citations

Response of the rat kidney to folic acid administration. II. Morphologic studies.

1972 • 29 citations

Retinoids and acne

1988 • 28 citations

The epileptogenic effects of folate derivatives in the rat

1973 • 27 citations

Some behavioural and EEG effects of ascorbic acid in rats

1986 • 27 citations

DISEASES OF THE NERVOUS SYSTEM

1942 • 26 citations

Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines

1990 • 26 citations

Vitamin E (tocopherols) in human cerebrospinal fluid

1991 • 26 citations

What is a retinoid?

1985 • 24 citations

Alteration of Amino Acid Metabolism in Epileptogenic Mice by Elevation of Brain Pyridoxal Phosphate

1985 • 22 citations

Effects of high level of vitamin C on tissue antioxidant status of guinea pigs.

1979 • 21 citations

A DOUBLE BLIND STUDY OFVITAMIN B₆ IN DOWN'S SYNDROME INFANTS. PART 1—CLINICAL AND BIOCHEMICAL RESULTS

1985 • 20 citations

Neurochemical and behavioral effects of diet related perinatal folic acid restriction

1976 • 20 citations

Necessity of ascorbic acid in the radioligand binding assay for [3H]5-hydroxytryptamine

1986 • 19 citations

Developmental toxicity evaluation of Bendectin in CD rats

1988 • 18 citations

Folic acid has a disinhibitory action in the rat hippocampal slice preparation

1985 • 17 citations

Chronic ascorbate potentiates the effects of chronic haloperidol on behavioral supersensitivity but not D2 dopamine receptor binding

1991 • 17 citations

Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis.

1990 • 15 citations

Antinociceptive Effects of Pyridoxine, Thiamine, and Cyanocobalamin in Rats

1990 • 15 citations

Guanyl nucleotide interactions with dopaminergic binding sites labeled by [3H]spiroperidol in human caudate and putamen: guanyl nucleotides enhance ascorbate-induced lipid peroxidation and cause an apparent loss of high affinity binding sites.

1988 • 14 citations

The Role of Vitamin E Therapy in High-Risk Neonates

1988 • 14 citations

Megadose Effects of Vitamin C on Vitamin B-12 Status in the Rat

1989 • 13 citations

Vitamin D: Is the brain a target?

1987 • 12 citations

Vitamin A intoxication presenting with ascites and a normal vitamin A level.

1988 • 12 citations

Neuronal Intermediate Filament Expression During Neurite Outgrowth from Explanted Goldfish Retina: Effect of Retinoic Acid

1990 • 12 citations

The influence of large doses of vitamin C on psychological functioning

1981 • 12 citations

Folates: epileptogenic effects and enhancing effects on [3H]TBOB binding to the GABAA-receptor complex

1990 • 11 citations

A relationship between vitamin B12, folic acid, ascorbic acid, and mercury uptake and methylation

1990 • 10 citations

Specific binding of fluorescein labelled serum retinol-binding protein to its cell surface receptor in isolated, purified bovine pigment epithelial cells

1980 • 9 citations

Effect of Single Oral Doses of Ascorbic Acid on Body Temperature in Healthy Guinea Pigs

1989 • 7 citations

[Neurological disorders in hyper- and hypovitaminosis].

1980 • 6 citations

Dietary Folic Acid and The Activity of Brain Cholinergic and γ-Aminobutyric Acid (GABA) Enzymes

1980 • 6 citations

Structure-activity relationships of retinoids as inhibitors of calmodulin-dependent human erythrocyte Ca2+-ATPase activity and calmodulin binding to membranes

1991 • 6 citations

An emerging view of vitamin D

1990 • 6 citations

Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E

1987 • 6 citations

Regulation of cellular retinol binding protein type II by 1,25-dihydroxyvitamin D3

1990 • 6 citations

Effects of Change in Dietary Folic Acid Content on Pentylenetetrazol Seizure Threshold in Rat

1977 • 6 citations

Developmental Pattern of DNA and Proteins in Brain, Liver, Lung and Heart of Rats Given Excess Vitamin A Postnatally

1983 • 6 citations

Pharmacologic doses of ascorbic acid prolong the effects of pentobarbital anesthesia.

1990 • 6 citations

Pyridoxal Phosphate as a Regulator of the Glucocorticoid Receptor^a

1990 • 5 citations

SOME ASPECTS OF THIAMINE TOXICITY

1948 • 5 citations

Action of Thiamine Applied Directly to the Cerebral Cortex

1947 • 5 citations

1 alpha,25-dihydroxyvitamin D3-induced regulation of protein kinase C gene expression during HL-60 cell differentiation.

1991 • 4 citations

Accumulation of ascorbate in rat cerebellum.

1988 • 4 citations

Vitamins: An evolutionary perspective

1985 • 3 citations

Brains and vitamins.

1991 • 1 citations