Plasma clearance, biodistribution and therapeutic properties of mitoxantrone encapsulated in conventional and sterically stabilized liposomes after intravenous administration in BDF1 mice

Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential

1985 • 2,037 citations

Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes

1990 • 1,962 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo

1991 • 1,370 citations

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

1988 • 1,103 citations

Association of blood proteins with large unilamellar liposomes in vivo. Relation to circulation lifetimes.

1992 • 454 citations

Long-circulating (sterically stabilized) liposomes for targeted drug delivery

1994 • 449 citations

Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes.

1992 • 422 citations

Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient

1986 • 363 citations

Influence of vesicle size, lipid composition, and drug-to-lipid ratio on the biological activity of liposomal doxorubicin in mice.

1989 • 351 citations

Liposomes with a large trapping capacity prepared by freezing and thawing of sonicated phospholipid mixtures

1981 • 342 citations

Mitoxantrone: A New Anticancer Drug with Significant Clinical Activity

1986 • 288 citations

Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.

1992 • 275 citations

Liposomes as in vivo carriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice.

1982 • 260 citations

The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey

1990 • 246 citations

Pharmacokinetics and Tissue Distribution of Doxorubicin Encapsulated in Stable Liposomes With Long Circulation Times

1989 • 210 citations

Characterization, toxicity and therapeutic efficacy of adrïamycin encapsulated in liposomes

1982 • 176 citations

Mitoxantrone (novantrone): a review of experimental and early clinical studies

1983 • 164 citations

Liposomal protection of adriamycin-induced cardiotoxicity in mice.

1980 • 158 citations

Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors.

1994 • 125 citations

Contribution of complement system on destabilization of liposomes composed of hydrogenated egg phosphatidylcholine in rat fresh plasma

1992 • 101 citations

Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor

1990 • 92 citations

Generating and loading of liposomal systems for drug-delivery applications

1989 • 91 citations

Technetium-labelled liposome imaging for deep-seated infection

1985 • 73 citations

Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice

1994 • 59 citations

The Use of Transmembrane pH Gradient-Driven Drug Encapsulation in the Pharmacodynamic Evaluation of Liposomal Doxorubicin

1994 • 48 citations

Differential uptake of gallium-67-labeled liposomes between tumors and inflammatory lesions in rats.

1986 • 40 citations

Evaluation of incorporation characteristics of mitoxantrone into unilamellar liposomes and analysis of their pharmacokinetic properties, acute toxicity, and antitumor efficacy

1991 • 31 citations

Phase I/II study of liposome-complexed mitoxantrone in patients with advanced breast cancer

1992 • 31 citations

Imaging in rheumatoid arthritis using liposomes labelled with technetium.

1986 • 28 citations

Spontaneous vesiculation of large multilamellar vesicles composed of saturated phosphatidylcholine and phosphatidylglycerol mixtures

1988 • 23 citations

Preclinical and Clinical Experience with Liposome-Encapsulated Mitoxantrone

1994 • 13 citations

Liposome-cell interactions in vitro

2005 • 5 citations