Phenotype and Function of T Cells in HIV Disease

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

1994 • 2,529 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Manual of Clinical Laboratory Immunology

1992 • 1,243 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Programmed Death of T Cells in HIV-1 Infection

1992 • 932 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome

1985 • 737 citations

The isolation and characterization of the human helper inducer T cell subset.

1985 • 708 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging.

1989 • 637 citations

Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV

1994 • 611 citations

CD8 naive T cell counts decrease progressively in HIV-infected adults.

1995 • 495 citations

Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study.

1993 • 452 citations

Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs.

1988 • 450 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1

1983 • 431 citations

Quantitative analysis of the human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein-Barr virus in late disease.

1993 • 427 citations

Developmental and maturational changes in human blood lymphocyte subpopulations

1992 • 415 citations

Human CD38: a glycoprotein in search of a function

1994 • 360 citations

Programmed Cell Death in AIDS-Related HIV and SIV Infections

1993 • 316 citations

CD4 percentage, CD4 number, and CD4:CD8 ratio in HIV infection: which to choose and how to use.

1989 • 311 citations

Human immunodeficiency virus-type 1 replication can be increased in peripheral blood of seropositive patients after influenza vaccination

1995 • 306 citations

Natural History of Human Immunodeficiency Virus Infections in Hemophiliacs: Effects of T-Cell Subsets, Platelet Counts, and Age

1987 • 305 citations

T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study

1989 • 297 citations

Serial CD4 lymphocyte counts and development of AIDS

1991 • 296 citations

Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation

1988 • 281 citations

CD8+ cell anti-HIV activity correlates with the clinical state of the infected individual.

1991 • 279 citations

Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders

1984 • 272 citations

Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor

1989 • 256 citations

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

1994 • 252 citations

Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens.

1993 • 239 citations

Failure of T-cell homeostasis preceding AIDS in HIV-1 infection

1995 • 235 citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

1994 • 232 citations

Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals

1989 • 225 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.

1989 • 221 citations

Elevated IFN-gamma and decreased IL-2 gene expression are associated with HIV infection.

1993 • 217 citations

Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28− T cells

1994 • 215 citations

Leucocyte typing V. White cell differentiation antigens

1995 • 213 citations

Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.

1990 • 198 citations

Early effects of HIV on CD4 lymphocytes in vivo.

1987 • 197 citations

Amplification of HTLV-III/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic responses.

1987 • 194 citations

Cd8+ Lymphocyte Activation At Human Immunodeficiency Virus Type 1 Seroconversion: Development Of Hla-Dr+ Cd38- Cd8+ Cells Is Associated With Subsequent Stable Cd4+ Cell Levels

1994 • 189 citations

An Activated CD8+ T Cell Phenotype Correlates with Anti-HIV Activity and Asymptomatic Clinical Status

1993 • 189 citations

Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection

1992 • 182 citations

Cytotoxic T lymphocytes against HIV

1990 • 180 citations

The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value

1992 • 174 citations

Selective increase of activation antigens HLA-DR and CD38 on CD45RO+ T lymphocytes during HIV-1 infection

1994 • 171 citations

Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy.

1984 • 168 citations

CD38 signaling by agonistic monoclonal antibody prevents apoptosis of human germinal center B cells

1994 • 164 citations

Intracellular Glutathione Levels in T Cell Subsets Decrease in HIV-Infected Individuals

1992 • 161 citations

Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.

1995 • 160 citations

Virus Burden in Long-Term Survivors of Human Immunodeficiency Virus (HIV) Infection Is a Determinant of Anti-HIV CD8+ Lymphocyte Activity

1995 • 157 citations

Expression of Costimulatory Molecule CD28 on T Cells in Human Immunodeficiency Virus Type 1 Infection: Functional and Clinical Correlations

1994 • 156 citations

Comparative expression of T9, T10, and Ia antigens on activated human T cell subsets

1981 • 155 citations

In Vitro T Cell Function, Delayed-Type Hypersensitivity Skin Testing, and CD4+ T Cell Subset Phenotyping Independently Predict Survival Time in Patients Infected with Human Immunodeficiency Virus

1995 • 154 citations

Ligation of CD38 suppresses human B lymphopoiesis.

1995 • 150 citations

Selective loss of T cell functions in different stages of HIV infection Early loss ofanti‐CD3‐induced T cell proliferation followed by decreased anti‐CD3‐induced cytotoxic T lymphocyte generation in AIDS‐related complex and AIDS

1990 • 149 citations

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

1991 • 145 citations

Human lymphocyte differentiation antigens HB-10 and HB-11. II. Differential production of B cell growth and differentiation factors by distinct helper T cell subpopulations.

1985 • 145 citations

Elevated relative fluorescence intensity of CD38 antigen expression on CD8+ T cells is a marker of poor prognosis in HIV infection: Results of 6 years of follow-up

1996 • 141 citations

Conversion of logarithmic channel numbers into relative linear fluorescence intensity

1988 • 133 citations

HIV-infected humans, but not chimpanzees, have circulating cytotoxic T lymphocytes that lyse uninfected CD4+ cells.

1990 • 131 citations

Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. Expansion in vivo of a nonclonogenic CD3+CD8+DR+CD25- T cell population.

1990 • 131 citations

CD8+ T lymphocytes of patients with AIDS maintain normal broad cytolytic function despite the loss of human immunodeficiency virus-specific cytotoxicity.

1990 • 120 citations

Reduced ecto-5'-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity.

1985 • 108 citations

A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells

1987 • 107 citations

Low T-cell responsiveness to activation via CD3/TCR is a prognostic marker for acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus-1 (HIV-1)-infected men

1990 • 104 citations

Development of Clinical Standards for Flow Cytometry

1993 • 97 citations

Clinical flow cytometry

1993 • 93 citations

CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection

1992 • 90 citations

Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients.

1995 • 87 citations

Expression of the fas antigen in patients infected with human immunodeficiency virus

1995 • 85 citations

A lectin‐binding soluble factor released by CD8⁺CD57⁺ lymphocytes from AIDS patients inhibits T cell cytotoxicity

1991 • 81 citations

Changes in T and non-T lymphocyte subsets following seroconversion to HIV-1: stable CD3+ and declining CD3- populations suggest regulatory responses linked to loss of CD4 lymphocytes. The Multicenter AIDS Cohort Study.

1993 • 79 citations

T-cell homeostasis: implications in HIV infection .

1993 • 76 citations

T Helper Cell Immune Dysfunction in Asymptomatic, HIV-1-Seropositive Individuals: The Role of TH1-TH2 Cross-Regulation

1992 • 76 citations

Effects of primary HIV-1 infection on subsets of CD4+ and CD8+ T lymphocytes

1995 • 75 citations

Expansion of a CD8+CD28- cell population in the blood and lung of HIV-positive patients.

1993 • 74 citations

Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection.

1991 • 73 citations

Selective alterations in immunoregulatory lymphocyte subsets in early HIV (human T-lymphotropic virus type III/lymphadenopathy-associated virus) infection

1987 • 69 citations

Heparin specifically inhibits binding of V3 loop antibodies to HIV-1 gp120, an effect potentiated by CD4 binding

1994 • 69 citations

Deficient autologous mixed lymphocyte reaction in Kaposi's sarcoma associated with deficiency of Leu-3+ responder T cells.

1983 • 67 citations

Early expression of cytokines in lymph nodes after treatment in vivo with Staphylococcus enterotoxin B

1994 • 65 citations

Subset markers of CD8(+) cells and their relation to enhanced cytotoxic T-cell activity during human immunodeficiency virus infection

1991 • 57 citations

Lymphocyte activation in HIV-1 infection. I. Predominant proliferative defects among CD45RO+ cells of the CD4 and CD8 lineages

1993 • 56 citations

Defective protein tyrosine phosphorylation and altered levels of p59^fyn and p56^ick in CD4 T cells from HIV-1 infected patients

1994 • 54 citations

Study of activated T cell in man

1986 • 53 citations

Decline in the CD4⁺Lymphocyte Population in the Blood of SIV-Infected Macaques Is Not Reflected in Lymph Nodes

1993 • 52 citations

Defective expression of T cell-associated glycoprotein in severe combined immunodeficiency.

1986 • 52 citations

HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.

1990 • 51 citations

Interrelationships Between Serologic Markers of Immune Activation and T Lymphocyte Subsets in HIV Infection

1990 • 49 citations

Lymphocyte subset analysis to predict progression to AIDS in a cohort of homosexual men in San Francisco

1989 • 49 citations

Expression of CD28 on CD8⁺ and CD4⁺ Lymphocytes During HIV Infection

1994 • 49 citations

Late-phase IgE-mediated reactions

1988 • 48 citations

Serum increases and lymphoid cell surface losses of IL-2 receptor CD25 in HIV infection: Distinctive parameters of HIV-induced change

1991 • 47 citations

Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection.

1993 • 41 citations

Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS)

1988 • 37 citations

Immunodeficiency in HIV infection and AIDS

1992 • 35 citations

Increases in soluble CD8 antigen in plasma, and CD8+ and CD8+CD38+ cells in human immunodeficiency virus type-1 infection

1992 • 33 citations

Patients with HIV infection have a reduced proportion of lymphocytes expressing the IL2 receptor p55 chain (TAC, CD25)

1991 • 33 citations

Phenotypically defined memory CD4+ cells are not selectively decreased in chronic HIV disease.

1994 • 33 citations

Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens.

1983 • 31 citations

HIV-related alterations in CD8 cell subsets defined by in Vitro survival characteristics

1991 • 27 citations

Subpopulations of CD4+ (T4+) cells in homosexual/bisexual men with persistent generalized lymphadenopathy.

1987 • 25 citations

Comparison of activation marker and TCR Vβ gene product expression by CD4+ and CD8+ T cells in peripheral blood and lymph nodes from HIV-infected patients

1995 • 23 citations

The Impaired in Vitro Production of Interleukin-2 in HIV Infection Is Negatively Correlated to the Number of Circulating CD4+ DR+ T Cells and Is Reversed by Allowing T Cells to Rest in Culture: Arguments for in Vivo CD4+ T Cell Activation

1993 • 23 citations

Limiting dilution analysis of interleukin‐2‐producing T cells responsive to recall and alloantigens in human immunodeficiency virus‐infected and uninfected individuals

1993 • 22 citations

Quantitation of antigen-specific immune responses in human immunodeficiency virus (HIV)-infected individuals by limiting dilution analysis

1992 • 21 citations

CD4+ T-Cell Number at the Time of Acquired Immunodeficiency Syndrome

1995 • 16 citations

Quantitative changes in t helper inducer (cd4⁺ cd45ra⁻), t suppressor inducer (cd4⁺ cd45ra⁺), t suppressor (cd8⁺ cd11b⁺), and t cytotoxic (cd8⁺ cd11b⁻) subsets in human immunodeficiency virus infection

1991 • 15 citations

Study of Activated T Cells in Man

1984 • 13 citations

Expansion of activated T lymphocytes (CD3+HLA/DR+) detectable in early stages of HIV-1 infection

1990 • 11 citations

Selective Stimulation of CD4⁺Versus CD8⁺T-Cell Subsets in Symptomatic and Asymptomatic HIV-1-Infected Individuals

1991 • 10 citations

Preferential loss of Leu 8?, CD45R?, HLA-DR+ CD8 cell subsets duringin vitro culture of mononuclear cells from human immunodeficiency virus type I (HIV)-seropositive former blood donors

1989 • 10 citations

Regulation and Functional Significance of T-Cell Subsets

1992 • 9 citations

Activated CD8+ Cells in HIV-Related Diseases

2015 • 9 citations

γ-Interferon-induced monocyte major histocompatibility complex class II antigen expression in individuals with acquired immune deficiency syndrome

1989 • 5 citations

Signal transduction defect in the acquired immunodeficiency syndrome and AIDS-related complex.

1993 • 3 citations