Mechanism of Calcium Channel Modulation by Dihydropyridine Agonists and Antagonists

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists

1984 • 1,292 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels

1983 • 1,010 citations

Sodium and calcium channels in bovine chromaffin cells

1982 • 983 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state.

1984 • 834 citations

Calcium Channels in Excitable Cell Membranes

1983 • 725 citations

A reinterpretation of mammalian sodium channel gating based on single channel recording

1983 • 675 citations

Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.

1984 • 553 citations

β-Adrenergic modulation of calcium channels in frog ventricular heart cells

1984 • 387 citations

Properties of single calcium channels in cardiac cell culture

1982 • 342 citations

Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells.

1984 • 323 citations

Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells

1983 • 304 citations

Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644.

1985 • 285 citations

The agonist effect of dihydropyridines on Ca channels

1984 • 264 citations

Calcium antagonism in heart and smooth muscle

1984 • 258 citations

Elementary currents through Ca2+ channels in Guinea pig myocytes

1983 • 220 citations

?-Adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp

1984 • 210 citations

High selectivity of calcium channels in single dialysed heart cells of the guinea‐pig.

1984 • 186 citations

Thromboxane synthesis by sources other than platelets in association with complement-induced pulmonary leukostasis and pulmonary hypertension in sheep.

1983 • 124 citations

Solubilization of the calcium antagonist receptor from rat brain.

1983 • 115 citations

SIMULTANEOUS ASSESSMENT OF EFFECTS OF CORONARY VASODILATORS ON THE CORONARY BLOOD FLOW AND THE MYOCARDIAL CONTRACTILITY BY USING THE BLOOD-PERFUSED CANINE PAPILLARY MUSCLE

1976 • 113 citations

The effects of insulin and anoxia on the metabolism of isolated mature rat cardiac myocytes

1980 • 110 citations

Solubilization and partial purification of putative calcium channels labelled with [3H]-nimodipine

1983 • 105 citations

The suction pipette method for internal perfusion and voltage clamp of small excitable cells

1980 • 103 citations

Molecular properties of the slow inward calcium channel. Molecular weight determinations by radiation inactivation and covalent affinity labeling.

1983 • 99 citations

Determination of the molecular size of the nitrendipine-sensitive Ca2+ channel by radiation inactivation

1983 • 69 citations

Prolongation of calcium channel open time by the dihydropyridine derivative BAY K 8644 in cardiac myocytes.

1984 • 58 citations

Photoalteration of calcium channel blockade in the cardiac Purkinje fiber

1984 • 39 citations

Correlation of nitrendipine and bay k 8644 binding to isolated canine heart sarcolemma with their pharmacological effects on the canine heart

1984 • 28 citations

Single Ion-Channel Current Measurements from Rat Brain Synaptosomes in Planar Lipid Bilayers

1984 • 16 citations