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Principal Component Analysis

1988 • 8,927 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Comprehensive medicinal chemistry

1991 • 1,195 citations

Correlation of Biological Activity of Phenoxyacetic Acids with Hammett Substituent Constants and Partition Coefficients

1962 • 986 citations

MDCK (Madin-Darby Canine Kidney) Cells: A Tool for Membrane Permeability Screening

1999 • 895 citations

Chemometrics, mathematics and statistics in chemistry

1984 • 535 citations

Correlating partitioning and caco-2 cell permeability of structurally diverse small molecular weight compounds.

1998 • 429 citations

Correlation of Drug Absorption with Molecular Surface Properties

1996 • 408 citations

pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs.

1998 • 401 citations

Estimation of permeability by passive diffusion through Caco-2 cell monolayers using the drugs' lipophilicity and molecular weight

1998 • 336 citations

IAM chromatography: an in vitro screen for predicting drug membrane permeability

1995 • 264 citations

Partitioning of Ionizing Molecules between Aqueous Buffers and Phospholipid Vesicles

1995 • 168 citations

A new look at lipid-membrane structure in relation to drug research.

1998 • 159 citations

Immobilized-liposome chromatographic analysis of drug partitioning into lipid bilayers

1995 • 124 citations

Theoretical Calculation and Prediction of Brain–Blood Partitioning of Organic Solutes Using MolSurf Parametrization and PLS Statistics

1998 • 124 citations

A new algorithm for optimal, distance-based experimental design

1992 • 108 citations

Theoretical calculation and prediction of Caco-2 cell permeability using MolSurf parametrization and PLS statistics.

1997 • 101 citations

Immobilized liposome and biomembrane partitioning chromatography of drugs for prediction of drug transport

1998 • 96 citations

Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics

1999 • 92 citations

Immobilized liposome chromatography of drugs for model analysis of drug-membrane interactions

1997 • 91 citations

Computer-assisted lead finding and optimization, current tools for medicinal chemistry

1997 • 85 citations

The Importance of Drug‐Membrane Interaction in Drug Research and Development

1992 • 43 citations

Relationships between octanol-water partition data, chromatographic indices and their dependence on pH in a set of beta-adrenoceptor blocking agents.

1990 • 34 citations