Pharmacogenetics: Clinical and Experimental Studies in Man

A familial disorder of uric acid metabolism and central nervous system function

1964 • 1,448 citations

Basic Mechanisms of the Epilepsies.

1970 • 1,131 citations

THE BEHAVIOR OF CHILDREN RECEIVING BENZEDRINE

1937 • 1,033 citations

The Schizophrenia-like Psychoses of Epilepsy

1963 • 952 citations

Psychiatric Disorders in Foster Home Reared Children of Schizophrenic Mothers

1966 • 786 citations

Manic Depressive Illness.

1970 • 720 citations

INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT

1969 • 705 citations

Aryl Hydrocarbon Hydroxylase Inducibility and Bronchogenic Carcinoma

1973 • 601 citations

HANDBOOK OF ABNORMAL PSYCHOLOGY

1961 • 561 citations

Genetic theory and abnormal behavior.

1970 • 531 citations

Psychiatric Illness in the Families of Hyperactive Children

1972 • 491 citations

The Greek Myths

1955 • 468 citations

Principles of Human Genetics

1950 • 465 citations

Oxford University Press

1968 • 427 citations

A family study of the hyperactive child syndrome.

1971 • 409 citations

Malignant hyperthermia: A statistical review

1970 • 408 citations

Blood platelets as a model for monoamine-containing neurones

1973 • 407 citations

A rapid microfluorimetric determination of monoamine oxidase

1965 • 406 citations

The Oxford University Press

2000 • 375 citations

Ethnic Differences in Alcohol Sensitivity

1972 • 373 citations

OUTCOME IN OFFSPRING OF CHRONIC ALCOHOLIC WOMEN

1974 • 367 citations

Basic mechanisms of the epilepsies

1970 • 322 citations

Monozygotic Twins. (Brought up apart and brought up together.)

1963 • 312 citations

Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia

1973 • 300 citations

A comparison of the capacities of isomers of amphetamine, deoxypipradrol and methylphenidate to inhibit the uptake of tritiated catecholamines into rat cerebral cortex slices, synaptosomal preparations of rat cerebral cortex, hypothalamus and striatum and into adrenergic nerves of rabbit aorta.

1972 • 296 citations

The Psychiatric Status of the Legal Families of Adopted Hyperactive Children

1973 • 272 citations

Monozygotic Twins, Brought up Apart and Brought up Together

1964 • 272 citations

PLASMA CONCENTRATION OF AMITRIPTYLINE AND CLINICAL RESPONSE

1972 • 263 citations

Metabolic Interactions Among Environmental Chemicals and Drugs

1972 • 261 citations

Relationship of acetyl transferase activity to antinuclear antibodies and toxic symptoms in hypertensive patients treated with hydralazine.

1970 • 257 citations

Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes.

1973 • 248 citations

An improved and simplified method of detecting the acetylator phenotype.

1969 • 238 citations

METABOLISM, TRANSFER AND STORAGE OF 5‐HYDROXYTRYPTAMINE IN BLOOD PLATELETS*

1968 • 237 citations

Mental Illness in the Biological and Adoptive Families of Adopted Schizophrenics

1971 • 229 citations

Genetic Control of Drug Levels in Man: Antipyrine

1968 • 225 citations

The genetic basis of the normal human electroencephalogram (EEG)

1970 • 223 citations

The Role of Brain Dopamine in Behavioral Regulation and the Actions of Psychotropic Drugs

1970 • 216 citations

Genetic and environmental factors affecting ethanol metabolism in man

1971 • 207 citations

PRINCIPLES OF HUMAN GENETICS

1961 • 204 citations

Chlorpromazie and Dopamine: Conformational Similarities that Correlate with the Antischizophrenic Activity of Phenothiazine Drugs

1971 • 199 citations

Handbook of Abnormal Psychology

1961 • 198 citations

Physiological Studies of the Hyperkinetic Child: I

1972 • 189 citations

Genetic Control of Drug Levels in Man: Phenylbutazone

1968 • 178 citations

Neuropsychopharmacology and the Affective Disorders

1969 • 168 citations

Linkage studies with X-chromosome markers in bipolar (manic-depressive) and unipolar (depressive) illnesses.

1974 • 166 citations

DIFFERENTIATION OF TWO GENETICALLY SPECIFIC TYPES OF DEPRESSION BY THE RESPONSE TO ANTI-DEPRESSANTS

1962 • 165 citations

Brain Sensitivity to Alcohol in Inbred Mouse Strains

1966 • 162 citations

Vasomotor sensitivity to alcohol in diverse Mongoloid populations.

1973 • 157 citations

Genetic control of dicumarol levels in man

1968 • 156 citations

Familial dysautonomia.

1955 • 145 citations

Benzedrine and dexedrine in the treatment of children's behavior disorders.

1950 • 133 citations

Reduced Catechol- O -Methyltransferase Activity in Red Blood Cells of Women with Primary Affective Disorder

1970 • 131 citations

DEPRESSION AND ANXIETY OCCURRING DURING RAUWOLFIA THERAPY

1955 • 127 citations

Comparative Psychotomimetic Effects of Stereoisomers of Amphetamine

1971 • 125 citations

Ethanol Metabolism in Various Racial Groups

1976 • 125 citations

Studies on the properties of the human alcohol dehydrogenase isozymes determined by the different loci ADH₁, ADH₂, ADH₃

1973 • 125 citations

INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK

1969 • 123 citations

On the Biological Role of Cyclic AMP

1970 • 122 citations

Affective disorder—VII: Alcoholism and affective disorder

1966 • 121 citations

Methemoglobinemia Provoked by Malarial Chemoprophylaxis in Vietnam

1968 • 119 citations

A new modification for studying 5-HT uptake by blood platelets: a re-evaluation of tricyclic antidepressants as uptake inhibitors

1974 • 117 citations

ATYPICAL HUMAN LIVER ALCOHOL DEHYDROGENASE

1968 • 116 citations

Toward a Biology of Affective Disorders

1971 • 114 citations

BENZEDRINE® AND DEXEDRINE® IN THE TREATMENT OF CHILDREN'S BEHAVIOR DISORDERS

1950 • 113 citations

Pharmacokinetics of desmethylimipramine and nortriptyline in man after single and multiple oral doses ? A cross-over study

1972 • 112 citations

The "One Child, One Drug" Myth of Stimulants in Hyperkinesis

1971 • 111 citations

EFFECTS OF URINARY pH ON AMPHETAMINE METABOLISM

1971 • 111 citations

BIOCHEMICAL AND GENETIC FACTORS REGULATING DILANTIN METABOLISM IN MAN*

1971 • 109 citations

The Genetics of Neurological Disorders

1967 • 107 citations

PSYCHOTROPIC EFFECTS OF CAFFEINE IN MAN. I. INDIVIDUAL DIFFERENCES IN SENSITIVITY TO CAFFEINE-INDUCED WAKEFULNESS.

1965 • 107 citations

Differentiation of two genetically specific types of depression by the response to antidepressant drugs.

1971 • 103 citations

Use of L-Dopa in the Detection of Presymptomatic Huntington's Chorea

1972 • 102 citations

Manic Depressive Illness

2023 • 100 citations

Levoamphetamine and Dextroamphetamine: Comparative Efficacy in the Hyperkinetic Syndrome

1972 • 99 citations

Genetic control of plasma dopamine- β -hydroxylase

1973 • 97 citations

Malignant hyperthermia: an investigation of five patients

1973 • 96 citations

The influence of acetylator phenotype on the effects of treating depression with phenelzine

1965 • 95 citations

Differential Catechol-O-Methyltransferase Activity in Unipolar and Bipolar Affective Illness

1971 • 91 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Genetic control of nortriptyline kinetics in man: a study of relatives of propositi with high plasma concentrations.

1971 • 86 citations

Ethanol metabolism in subiects possessing typical and atypical liver alcohol dehydrogenase

1967 • 84 citations

Inheritance of very low serum dopamine-beta-hydroxylase activity.

1975 • 82 citations

ACETYLATOR STATUS AND RESPONSE TO PHENELZINE IN DEPRESSED PATIENTS

1973 • 82 citations

A pseudocholinesterase variant (E Cynthiana) associated with elevated plasma enzyme activity.

1969 • 76 citations

Induction of Abortion by Extra-amniotic Administration of Prostaglandins E2 and F2

1972 • 76 citations

ATYPICAL HUMAN LIVER ALCOHOL DEHYDROGENASE

1968 • 73 citations

Genetic Control of Phenylbutazone Metabolism in Man

1970 • 72 citations

Variability of Human Drug Response

1989 • 72 citations

Anaesthetic-induced Malignant Hyperpyrexia: A Suggested Method of Treatment

1971 • 71 citations

Correlation of erythrocyte catechol-O-methyltransferase activity between siblings

1974 • 67 citations

Plasma levels of chlorpromazine and some of its relatively non-polar metabolites in psychiatric patients

1968 • 67 citations

Acute effects of diphenylhydantoin in relation to plasma levels: Behavioural and psychophysiological studies

1972 • 62 citations

COMMENT

1957 • 60 citations

Restricted Variation in the Glycolytic Enzymes of Human Brain and Erythrocytes

1973 • 58 citations

PLASMA UPTAKE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE AND PLASMA-CATECHOLAMINE LEVELS IN PATIENTS WITH HUNTINGTON'S CHOREA

1974 • 58 citations

Current trends in chemical carcinogenesis.

1973 • 56 citations

Isoniazid-Induced Acne and Pellagra

1974 • 56 citations

Time relations of the effects of alcohol compared to placebo

1968 • 52 citations

Hereditary Predisposition in Drug-Induced Parkinsonism

1962 • 52 citations

INDIVIDUAL DIFFERENCES IN THE PHARMACOKINETICS OF MONOMETHYLATED TRICYCLIC ANTIDEPRESSANTS: ROLE OF GENETIC AND ENVIRONMENTAL FACTORS AND CLINICAL IMPORTANCE*

1971 • 52 citations

Glutethimide Poisoning

1975 • 48 citations

Serotonin and Platelet Function in Duchenne Muscular Dystrophy

1973 • 48 citations

Porphyria and King George III

1969 • 48 citations

Wakefulness caused by caffeine

1964 • 44 citations

The effect of electroconvulsive shock on the cerebral metabolism of dopamine and 5-hydroxytryptamine

1968 • 40 citations

Liver alcohol dehydrogenase in a Japanese population.

1972 • 38 citations

Drug Plasma Levels and Clinical Effect [Abridged]

1971 • 35 citations

Choice of Antipsychotic Drugs

1970 • 34 citations

Electroencephalographic changes in man during use and withdrawal of barbiturates in moderate dosage

1958 • 34 citations

Clinical and Metabolic Studies with Imipramine in Man

1971 • 34 citations

GENETICS AS A TOOL IN ALCOHOL RESEARCH

1972 • 33 citations

Annotation: human ecology, an expanding role for the human geneticist.

1971 • 32 citations

Decrease of the 3,4-Dihydroxyphenylalanine (DOPA) Decarboxylase Activities in Human Erythrocytes and Mouse Tissues after Administration of DOPA

1971 • 31 citations

Variability in Human Drug Response

1974 • 30 citations

Genetic issues in the syndrome of minimal brain dysfunction.

1973 • 28 citations

A BIOCHEMICAL AND GENETIC APPROACH TO ALCOHOLISM

1972 • 26 citations

Predicting Amphetamine Response in Hyperkinetic Children by Electronic Pupillography

1973 • 24 citations

Taste sensitivity may be used to predict pharmacological effects

1968 • 17 citations

Hereditary malignant hyperpyrexia associated with muscle adenylate kinase deficiency

1974 • 17 citations

Use of CNS Stimulant Medication in Averaged Electroencephalic Audiometru with Children with MBD

1975 • 17 citations

N-Acetyl-transferase and Serotonin Metabolism in Man and, other Species, I

1969 • 17 citations

Inter-patient variation in chlorpromazine metabolism.

1965 • 16 citations

Interpatient variation and significance of plasma levels of chlorpromazine in psychotic patients.

1972 • 14 citations

Urinary d-glucaric acid excretion in normal and G-6-PD-deficient children with favism

1974 • 13 citations

ALTERED DRUG RESPONSE IN FAMILIAL DYSAUTONOMIA

1968 • 13 citations

Experimental pharmacogenetics : physiopathology of heredity and pharmacologic responses

1963 • 12 citations

Clinical implications of the relation between taste sensitivity and the appearance of extrapyramidal side effects.

1966 • 12 citations

Acetylation of serotonin in vitro by a human N-acetyltransferase

1969 • 12 citations

Alcoholism: a pharmacogenetic disorder.

1975 • 12 citations

Chlorpromazine Metabolism V: Disposition of Free and Conjugated Metabolites in Blood Fractions of Schizophrenic Patients

1972 • 11 citations

Isoniazid-induced acne and pellagra. Occurrence in slow inactivators of isoniazid

1974 • 11 citations

The metabolism of 5-hydroxytryptamine by blood platelets from children with mongolism

1973 • 10 citations

Decarboxylation of 3,4-Dihydroxyphenylalanine (DOPA) by Erythrocytes: A Reaction Promoted by Methemoglobin and Other Ferriheme Proteins

1972 • 8 citations

THE CHILDREN OF ADDICTS: WHAT DO THEY INHERIT?

1972 • 7 citations

Chemotherapy of Mental Depression

1970 • 3 citations

On the forensic-psychiatric significance of alcohol loading tests under EEG control.

1971 • 2 citations