Factors in Selection of New Anthracyclines

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.

1979 • 492 citations

Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).

1980 • 357 citations

Spin-trapping and direct electron spin resonance investigations of the redox metabolism of quinone anticancer drugs

1980 • 317 citations

Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents

1977 • 258 citations

Diminished superoxide anion generation by reduced 5-iminodaunorubicin relative to daunorubicin and the relationship to cardiotoxicity of the anthracycline antitumor agents

1979 • 99 citations

Structure-activity relationships of anthracyclines relative to effects on macromolecular syntheses.

1978 • 96 citations

5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline

1979 • 94 citations

Model Systems for Cardiotoxic Effects of Anthracyclines

2015 • 64 citations

Adriamycin analogs. 3. Synthesis of N-alkylated anthracyclines with enhanced efficacy and reduced cardiotoxicity

1979 • 59 citations

Synthesis and preliminary antitumor evaluation of 5-iminodoxorubicin

1981 • 46 citations

The clinical evaluation of analogs ? III. Anthracyclines

1980 • 33 citations

Synthesis and antitumor activity of 7-O-(3,4-di-O-acetyl-2,6-dideoxy-α-l-lyxo-hexopyranosyl)adriamycinone

1981 • 25 citations

Effects of 5-iminodaunorubicin on nucleoli of rats

1980 • 19 citations