Trisomy 21 (Down syndrome): studying nondisjunction and meiotic recombination by using cytogenetic and molecular polymorphisms that span chromosome 21.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.

1977 • 1,372 citations

A cytogenetic study of 1000 spontaneous abortions

1980 • 671 citations

Chiasma Frequency and Maternal Age in Mammals

1968 • 439 citations

Functional Aspects of Satellite DNA and Heterochromatin

1979 • 425 citations

Purification of genomic sequences from bacteriophage libraries by recombination and selectionin vivo

1983 • 221 citations

Meiosis in the foetal mouse ovary

1982 • 182 citations

Further studies on bivalent chiasma frequency in human males with normal karyotypes

1985 • 160 citations

The Origin Of Humankind

1982 • 141 citations

Non‐disjunction in trisomy 21: study of chromosomal heteromorphisms in 110 families

1980 • 115 citations

Satellite DNA and heterochromatin variants: The case for unequal mitotic crossing over

1979 • 109 citations

Chiasmata, meiotic univalents, and age in relation to aneuploid imbalance in mice

1976 • 104 citations

Parental origin of autosomal trisomies

1984 • 103 citations

Isolation of polymorphic DNA fragments from human chromosome 4

1987 • 100 citations

Maternal-age effect in aneuploidy: does altered embryonic selection play a role?

1982 • 96 citations

Human cytoplasmic superoxide dismutase cDNA clone: a probe for studying the molecular biology of Down syndrome.

1982 • 95 citations

Effect of maternal age on autosomal trisomies

1980 • 93 citations

Cloned DNA probes regionally mapped to human Chromosome 21 and their use in determining the origin of nondisjunction

1985 • 93 citations

Origin of nondisjunction in trisomy 21 syndrome: All studies compiled, parental age analysis, and international comparisons

1983 • 92 citations

The effects of ageing on the meiotic chromosomes of male and female mice

1977 • 88 citations

Parental origin of the extra chromosome in Down's syndrome

1977 • 83 citations

Regional localization of DNA sequences on chromosome 21 using somatic cell hybrids.

1986 • 82 citations

Tooth sizes in two males with deletions of the long arm of the Y‐chromosome

1981 • 68 citations

Chiasma and univalent frequencies in aging female mice

1973 • 66 citations

Use of a chromosome 21 cloned DNA probe for the analysis of non-disjunction in Down syndrome

1984 • 60 citations

The origin of the extra chromosome 21 in Down syndrome

1978 • 55 citations

Absence of correlation between univalent formation and meiotic nondisjunction in aged female Chinese hamsters

1983 • 52 citations

Origin of the extra chromosome No. 21 in Down's syndrome

1976 • 52 citations

Meiosis in the foetal mouse ovary

1983 • 50 citations

Analyses of diplotene chiasma frequencies in mouse oocytes and spermatocytes in relation to ageing and sexual dimorphism

1979 • 42 citations

Human chromosome 21-encoded cDNA clones

1986 • 38 citations

Down syndrome rates and relaxed selection at older maternal ages.

1983 • 38 citations

ATTRITION OF TRISOMIES AS A MATERNAL SCREENING DEVICE

1986 • 36 citations

Maternal age and origin of non-disjunction in trisomy 21.

1980 • 29 citations

Trisomy 21: Origin of non-disjunction

1982 • 29 citations

Recent evolution of DNA sequence homology in the pericentromeric regions of human acrocentric chromosomes

1984 • 28 citations

The 724 family of DNA sequences is interspersed about the pericentromeric regions of human acrocentric chromosomes

1986 • 27 citations

Down syndrome and maternal age: the effect of erroneous assignment of parental origin.

1987 • 27 citations

Analysis of nucleolar organizing regions in parents of trisomic spontaneous abortions

1987 • 22 citations

Reduced Recombination Rate on Chromosomes 21 That Have Undergone Nondisjunction

1986 • 21 citations

Retrieval of human DNA from rodent-human genomic libraries by a recombination process

1983 • 19 citations

Comparison of sequence repetitiveness of human cDNA and genomic DNA using the miniplasmid vector, piVX

1983 • 13 citations

The study of chromosome non-disjunction in man

1981 • 3 citations