Transcriptional activation by Myc is under negative control by the transcription factor AP-2.

The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins

1988 • 3,479 citations

POLYAMINES

1984 • 2,996 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

1983 • 2,350 citations

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

1991 • 1,650 citations

Transcription factor AP-2 mediates induction by two different signal-transduction pathways: Protein kinase C and cAMP

1987 • 1,391 citations

GAL4-VP16 is an unusually potent transcriptional activator

1988 • 1,379 citations

Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element

1990 • 1,326 citations

Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen

1987 • 969 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Sequence-Specific DNA Binding by the c-Myc Protein

1990 • 893 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

1993 • 786 citations

The ornithine decarboxylase gene is a transcriptional target of c-Myc.

1993 • 759 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

1993 • 711 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

Methylation-Sensitive Sequence-Specific DNA Binding by the c-Myc Basic Region

1991 • 596 citations

Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.

1991 • 593 citations

The MYC protein activates transcription of the alpha-prothymosin gene.

1991 • 589 citations

Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

1991 • 576 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Oncogenic activity of the c-Myc protein requires dimerization with Max

1993 • 543 citations

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice.

1993 • 536 citations

Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

1986 • 533 citations

Analysis of the DNA-binding and activation properties of the human transcription factor AP-2.

1991 • 519 citations

Myc and Max proteins possess distinct transcriptional activities

1992 • 478 citations

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

1989 • 475 citations

Definition of regions in human c-myc that are involved in transformation and nuclear localization.

1987 • 457 citations

Myc and Max associate in vivo.

1992 • 428 citations

An amino-terminal c-myc domain required for neoplastic transformation activates transcription.

1990 • 413 citations

Binding of myc proteins to canonical and noncanonical DNA sequences.

1993 • 375 citations

Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface.

1986 • 374 citations

Myc—Max—Mad: a transcription factor network controlling cell cycle progression, differentiation and death

1994 • 365 citations

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

1992 • 359 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus

1982 • 298 citations

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

1993 • 294 citations

Nuclear Localization and DNA Binding Properties of a Protein Expressed by Human c- myc Oncogene

1984 • 288 citations

Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29

1983 • 287 citations

Max: functional domains and interaction with c-Myc.

1992 • 280 citations

Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.

1993 • 275 citations

Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts.

1986 • 272 citations

Regulatory crosstalk at composite response elements

1991 • 261 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Nuclear location of the putative transforming protein of avian myelocytomatosis virus

1982 • 245 citations

Ornithine Decarboxylase Is a Mediator of c-Myc-Induced Apoptosis

1994 • 238 citations

Characterization of a Dimerization Motif in AP-2 and Its Function in Heterologous DNA-Binding Proteins

1991 • 234 citations

Transcription factor AP2 and its role in epidermal-specific gene expression.

1991 • 234 citations

High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.

1995 • 224 citations

Fibroblast lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneic animals

1984 • 212 citations

Nucleotide sequence analysis of the chicken c-myc gene reveals homologous and unique coding regions by comparison with the transforming gene of avian myelocytomatosis virus MC29, delta gag-myc.

1983 • 187 citations

c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif.

1993 • 186 citations

Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.

1983 • 184 citations

Determination of the c-MYC DNA-binding site.

1991 • 181 citations

An Amino-Terminal c-Myc Domain Required for Neoplastic Transformation Activates Transcription

1990 • 153 citations

c-Myc induces the expression and activity of ornithine decarboxylase.

1993 • 152 citations

Prothymosin alpha antisense oligomers inhibit myeloma cell division.

1991 • 145 citations

Regulation of a human epidermal keratin gene: sequences and nuclear factors involved in keratinocyte-specific transcription.

1990 • 144 citations

Sequence-specific DNA binding by Myc proteins.

1991 • 130 citations

An E-box element localized in the first intron mediates regulation of the prothymosin alpha gene by c-myc.

1994 • 127 citations

Apoptosis II: The Molecular Basis of Apoptosis in Disease

1994 • 126 citations

An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.

1993 • 124 citations

Sequence-Specific Transcriptional Activation by Myc and Repression by Max

1993 • 124 citations

Binding of Myc Proteins to Canonical and Noncanonical DNA Sequences

1993 • 123 citations

The pRSET family of T7 promoter expression vectors for Escherichia coli

1993 • 113 citations

A comparative analysis of N-myc and c-myc expression and cellular proliferation in mouse organogenesis

1991 • 107 citations

Definition of Regions in Human c-myc that are Involved in Transformation and Nuclear Localization

1987 • 106 citations

Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer.

1993 • 100 citations

Retinoid-mediated transcriptional regulation of keratin genes in human epidermal and squamous cell carcinoma cells.

1991 • 100 citations

N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation.

1994 • 93 citations

Transcription factor AP-2 is tissue-specific in Xenopus and is closely related or identical to Keratin Transcription Factor 1 (KTF-1)

1991 • 91 citations

Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product

1991 • 89 citations

Repression of Cyclin D1: a Novel Function of MYC

1994 • 84 citations

Behavior of myc and ras Oncogenes in Transformation of Rat Embryo Fibroblasts

1986 • 67 citations

Cloning of mid-G1 serum response genes and identification of a subset regulated by conditional myc expression.

1994 • 51 citations

Prothymosin alpha gene expression correlates with proliferation, not differentiation, of HL-60 cells

1993 • 42 citations

Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.

1994 • 39 citations

Functional differences between the Oct2 transactivation domains determine the transactivation potential of individual Oct2 isoforms

1994 • 38 citations

An Alternatively Spliced mRNA from the AP-2 Gene Encodes a Negative Regulator of Transcriptional Activation by AP-2

1993 • 28 citations

Differentiation-Linked Expression of Prothymosin α Gene in Human Myeloid Leukemic Cells

1993 • 24 citations

An E-Box Element Localized in the First Intron Mediates Regulation of the Prothymosin a Gene by c-myc

1994 • 22 citations