Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia

The biology of VEGF and its receptors

2003 • 9,272 citations

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

2003 • 3,707 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Preeclampsia: An excessive maternal inflammatory response to pregnancy

1999 • 1,855 citations

Phase II, Randomized Trial Comparing Bevacizumab Plus Fluorouracil (FU)/Leucovorin (LV) With FU/LV Alone in Patients With Metastatic Colorectal Cancer

2002 • 1,699 citations

J Soc Gynecol Investig

2005 • 1,243 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Etiology and pathogenesis of preeclampsia: Current concepts

1998 • 774 citations

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

2002 • 637 citations

Recent Insights into the Pathogenesis of Pre-eclampsia

2002 • 603 citations

Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria

2003 • 519 citations

Risk factors associated with preeclampsia in healthy nulliparous women

1997 • 485 citations

Placental Cytokines and the Pathogenesis of Preeclampsia

1997 • 476 citations

A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation1

1998 • 408 citations

Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia

2003 • 396 citations

VEGF165 mediates glomerular endothelial repair

1999 • 294 citations

Vascular Endothelial Growth Factor Governs Endothelial Nitric-oxide Synthase Expression via a KDR/Flk-1 Receptor and a Protein Kinase C Signaling Pathway

1999 • 292 citations

Colocalisation of Vascular Endothelial Growth Factor and Its Flt-1 Receptor in Human Placenta

1995 • 254 citations

Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1

1994 • 246 citations

The effect of placental syncytiotrophoblast microvillous membranes from normal and pre‐eclamptic women on the growth of endothelial cells in vitro

1993 • 232 citations

Release and Complex Formation of Soluble VEGFR-1 from Endothelial Cells and Biological Fluids

2000 • 217 citations

Phenotypic and metabolic characteristics of monocytes and granulocytes in preeclampsia

2001 • 179 citations

Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre‐eclampsia

1997 • 158 citations

Preeclampsia: The Endothelium, Circulating Factor(s) and Vascular Endothelial Growth Factor

1999 • 112 citations

Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors.

2001 • 107 citations

Maternal plasma vascular endothelial growth factor concentrations in normal and hypertensive pregnancies and their relationship to peripheral vascular resistance

2001 • 99 citations

Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor

1999 • 53 citations