Drugs Under Clinical Trial

Epilepsy: A Comprehensive Textbook

2008 • 2,352 citations

Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs

1989 • 1,235 citations

The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel

1996 • 1,164 citations

Epilepsy: A Comprehensive Textbook

1998 • 506 citations

New Antiepileptic Drugs

1996 • 344 citations

Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats

1993 • 272 citations

The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes

1995 • 255 citations

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

1997 • 245 citations

D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures

1996 • 240 citations

Cognitive Consequences of Two‐Thirds Anterior Temporal Lobectomy on Verbal Memory in 144 Patients: A Three‐Month Follow‐Up Study

1996 • 232 citations

Predictors of Intractable Epilepsy in Childhood: A Case‐Control Study

1996 • 224 citations

ucb L059, a novel anti-convulsant drug: pharmacological profile in animais

1992 • 208 citations

Survey of Seizure Disorders in the French Southwest. I. Incidence of Epileptic Syndromes

1990 • 197 citations

Oxcarbazepine

1992 • 196 citations

Effects of levetiracetam, a novel antiepileptic drug, on convulsant activity in two genetic rat models of epilepsy

1995 • 193 citations

New Anticonvulsant Drugs

1994 • 191 citations

Photosensitive epilepsy: a model to study the effects of antiepileptic drugs. Evaluation of the piracetam analogue, levetiracetam

1996 • 175 citations

The new generation of antiepileptic drugs: advantages and disadvantages

1996 • 162 citations

Oxcarbazepine: Mechanisms of Action

1994 • 148 citations

Antiparkinsonian effects of remacemide hydrochloride, a glutamate antagonist, in rodent and primate models of Parkinson's disease

1994 • 147 citations

Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentin

1993 • 145 citations

D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures

1996 • 141 citations

Voltage‐Activated Calcium Channels: Targets of Antiepileptic Drug Therapy?

1997 • 136 citations

The new generation of antiepileptic drugs: advantages and disadvantages

1996 • 125 citations

Initial Human Experience with Ganaxolone, a Neuroactive Steroid with Antiepileptic Activity

1997 • 122 citations

Effects of polytherapy with phenytoin, carbamazepine, and stiripentol on formation of 4-ene-valproate, a hepatotoxic metabolite of valproic acid

1990 • 118 citations

Pharmacological and electrographic properties of epileptiform activity induced by elevated K2+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices

1993 • 111 citations

Stiripentol kinetics in epilepsy: Nonlinearity and interactions

1984 • 98 citations

Comprehensive Epileptology

1991 • 96 citations

Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant.

1994 • 82 citations

Biological profile of the metabolites and potential metabolites of the anticonvulsant remacemide

1992 • 80 citations

The pharmacokinetics of oxcarbazepine and its active metabolite 10‐hydroxy‐carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid

1993 • 79 citations

The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata

1996 • 74 citations

Cognitive effects of a new pyrrolidine derivative (levetiracetam) in patients with epilepsy

1995 • 71 citations

Stiripentol in Atypical Absence Seizures in Children: An Open Trial

1993 • 67 citations

A new type of anticonvulsant, stiripentol. Pharmacological profile and neurochemical study.

1984 • 65 citations

Occipital Paroxysmal Discharges Suppressed By Eye Opening: Variability in Clinical and Seizure Manifestations in Childhood

1995 • 60 citations

The effects of anticonvulsant agents on 4-aminopyridine induced epileptiform activity in rat hippocampus in vitro

1995 • 59 citations

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

1992 • 57 citations

Pharmacokinetics of Stiripentol in Normal Man: Evidence of Nonlinearity

1983 • 57 citations

Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat

1991 • 57 citations

Comparison of the effects of losigamone and its isomers on maximal electroshock induced convulsions in mice and on three different patterns of low magnesium induced epileptiform activity in slices of the rat temporal cortex

1992 • 52 citations

ucb L059, a novel anticonvulsant, reduces bicuculline-induced hyperexcitability in rat hippocampal CA3 in vivo

1995 • 44 citations

Efficacy and tolerability study of ucb L059 in patients with refractory epilepsy

1996 • 44 citations

Profile of SB‐204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures

1997 • 44 citations

New Antiepileptic Drugs

1992 • 42 citations

Carbamazepine Dose Requirements During Stiripentol Therapy: Influence of Cytochrome P‐450 Inhibition Stiripentol

1991 • 42 citations

Progress report on new antiepileptic drugs A summary of the Second Eilat Conference

1995 • 41 citations

Antiepileptic and neuroprotective potential of remacemide hydrochloride

1993 • 41 citations

Neuroprotective effect of remacemide hydrochloride in focal cerebral ischemia in the cat

1994 • 40 citations

The metabolic fate of stiripentol in man.

1986 • 39 citations

Comparative anticonvulsant potency and pharmacokinetics of (+)- and (−)-enantiomers of stiripentol

1992 • 39 citations

Preclinical profile of remacemide: A novel anticonvulsant effective against maximal electroshock seizures in mice

1990 • 37 citations

Effects of the Anticonvulsant Losigamone and Its Isomers on the GABA_A Receptor System

1995 • 37 citations

Pharmacokinetic Profile of a New Anticonvulsant, Stiripentol, in the Rhesus Monkey

1983 • 37 citations

Levetiracetam

1997 • 36 citations

Remacemide HC1 and its metabolite, FPL 12495AA, limit action potential firing frequency and block NMDA responses of mouse spinal cord neurons in cell culture

1996 • 36 citations

Stereoselective metabolism of a new anticonvulsant drug candidate, losigamone, by human liver microsomes.

1996 • 35 citations

Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference

1996 • 35 citations

D‐23129: A New Anticonvulsant Compound

1996 • 35 citations

Characterization of the binding of [³H]‐SB‐204269, a radiolabelled form of the new anticonvulsant SB‐204269, to a novel binding site in rat brain membranes

1997 • 34 citations

Classification of compounds for prevention of NMDLA-induced seizures/mortality, or maximal electroshock and pentylenetetrazol seizures in mice and antagonism of MK801 binding in vitro.

1992 • 34 citations

Michaelis‐Menten Kinetics of Stiripentol in Normal Humans

1984 • 33 citations

Effects of the tetronic acid derivatives AO33 (losigamone) and AO78 on epileptiform activity and on stimulus-induced calcium concentration changes in rat hippocampal slices

1990 • 27 citations

A New Surgical Method for the Treatment of Hemispheric Dysplastic Lesions.

1996 • 26 citations

[Neurophysiological and therapeutic evaluation of stiripentol in epilepsy. Preliminary results].

1988 • 25 citations

Intra- and inter-subject variabilities of CGP 33101 after replicate single oral doses of two 200-mg tablets and 400-mg suspension.

1995 • 24 citations

Mutual Interaction Between Remacemide Hydrochloride and Carbamazepine: Two Drugs with Active Metabolites

1996 • 23 citations

Losigamone decreases spontaneous synaptic activity in cultured hippocampal neurons

1997 • 22 citations

The effects of anticonvulsant compounds on 4-aminopyridine-induced de novo synthesis of neurotransmitter amino acids in rat hippocampus in vitro

1995 • 20 citations

Anticonvulsant effects of tetronic acid derivatives on picrotoxin induced epileptiform activity in rat hippocampal slices

1990 • 20 citations

Stiripentol in Acute/Chronic Efficacy Tests in Monkey Model

1985 • 19 citations

Preclinical profile of stereoisomers of the anticonvulsant remacemide in mice

1991 • 19 citations

The Early Phase of Cryogenic Lesions: An Experimental Model of Seizures Updated

1987 • 18 citations

Amygdaloid Kindling in the Japanese Monkey Macacafuscata: Pre‐ and Postictal Discharges.

1996 • 17 citations

Effects of losigamone on synaptic potentials and spike frequency habituation in rat entorhinal cortex and hippocarnpal CA1 neurones

1995 • 15 citations

Pharmacokinetics of losigamone, a new antiepileptic drug, in healthy male volunteers.

1996 • 14 citations

Dezinamide for partial seizures

1994 • 13 citations

Surgical Management of Epilepsy Associated with Cerebral Neurocytoma.

1996 • 11 citations

AWD 140–190: a new anticonvulsant with a very good margin of safety

1997 • 11 citations

Etude pharmacocinétique du3H-stiripentol chez le rat

1982 • 11 citations

Epilepsy Surgery in Children: Experience in Our Pediatric Department.

1996 • 10 citations

Complex Partial Seizures of Medial Frontal Cortex Origin: Report of Two Surgical Cases.

1996 • 9 citations

Recurrent Excitation of Dentate Granule Cells in Kindled Rat During Self‐sustained Seizure Activity Probably Via Sprouted Mossy Fibers.

1996 • 9 citations

High-performance liquid chromatographic method for the simultaneous measurement of remacemide (a novel anticonvulsant and cerebroprotectant) and an active metabolite in human plasma

1992 • 8 citations

The anticonvulsant action of AHR-11748 on kindled amygdaloid seizures in rats

1987 • 8 citations

Pathoetiology and Seizure Outcome After Surgical Treatment of Intractable Temporal Lobe Epilepsy.

1996 • 8 citations

Pharmacodynamics and pharmacokinetics of AHR-11748, a new antiepileptic agent, in rodents

1990 • 6 citations

Quantitation of the novel anticonvulsant remacemide in rat and dog plasma and urine: application of the plasma methodology to measure the plasma protein binding of remacemide

1992 • 6 citations

Expression of Major Histocompatibility Complex Class I and II Antigens in the Human Hippocampus with Temporal Lobe Epilepsy.

1996 • 5 citations

Pharmacokinetic and Dose Tolerability Study of ADD 94057 in Comedicated Patients with Partial Seizures

1992 • 4 citations

Failure of Chronic Treatment with Abecarnil to Induce Contingent and Noncontingent Tolerance in Pentylenetetrazol‐Kindled Rats

1996 • 3 citations

Epilepsy in Childhood with Frontal EEG Epileptiform Activity.

1996 • 2 citations

Spect findings in extratemporal focal cortical dysplasis

1997 • 1 citations

ChemInform Abstract: Synthesis of Novel trans‐4‐(Substituted‐benzamido)‐3,4‐dihydro‐2H‐ benzo(b)pyran‐3‐ol Derivatives as Potential Anticonvulsant Agents with a Distinctive Binding Profile.

1997 • 1 citations

Deleted Work

1955 • 0 citations