Preclinical profile of the anticonvulsant remacemide and its enantiomers in the rat

Statistical principles in experimental design.

1962 • 27,228 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

BMDP Statistical Software 1981.

1984 • 5,347 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Manual of pharmacologic calculations with computer programs

1988 • 1,456 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations

1988 • 822 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

1975 • 637 citations

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

1988 • 517 citations

Antiepileptic Drug Development Program

1984 • 490 citations

The novel anticonvulsant MK‐801 binds to the activated state of the N‐methyl‐<scp>d</scp>‐aspartate receptor in rat brain

1987 • 452 citations

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

1983 • 437 citations

Influences ions, enzymes, and detergents on gamma-aminobutyric acid-receptor binding in synaptic membranes of rat brain.

1977 • 384 citations

Behavioral and neurochemical effects following neurotoxic lesions of a major cholinergic input to the cerebral cortex in the rat1

1983 • 371 citations

The FDA perspective on the development of stereoisomers

1989 • 280 citations

Excitatory amino acid synaptic mechanisms and neurological function

1986 • 231 citations

Results of a Nationwide Veterans Administration Cooperative Study Comparing the Efficacy and Toxicity of Carbamazepine, Phenobarbital, Phenytoin, and Primidone

1987 • 224 citations

The kindling model of epilepsy

1983 • 197 citations

On the inhibitory action of mersalyl on microsomal drug oxidation: A rigid organization of the electron transport chain

1971 • 188 citations

Micromolar Affinity Benzodiazepine Receptors: Identification and Characterization in Central Nervous System

1982 • 152 citations

Antiepileptic Drug Development Program: A Cooperative Effort of Government and Industry

1989 • 130 citations

Antiepileptic Drug Development: I. History and a Program for Progress

1978 • 97 citations

Glutamate and aspartate binding sites are enriched in synaptic junctions isolated from rat brain

1981 • 82 citations

Adverse Neuropsychiatric Effects of Anticonvulsant Drugs

1985 • 77 citations

Chromodacryorrhea in laboratory rats (Rattus norvegicus): etiologic considerations.

1980 • 75 citations

Psychomotor impairment and anticonvulsant therapy in adult epileptic patients

1987 • 73 citations

Chloride and calcium ions separte L-glutamate receptor populations in synaptic membranes

1983 • 72 citations

Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy

1983 • 70 citations

The Hippocampal Slice: A System for Studying the Pharmacology of Seizures and for Screening Anticonvulsant Drugs

1977 • 65 citations

Experimental Psychopharmacology

1987 • 47 citations

Site of anticonvulsant action on sodium channels: autoradiographic and electrophysiological studies in rat brain.

1987 • 43 citations

Preclinical profile of remacemide: A novel anticonvulsant effective against maximal electroshock seizures in mice

1990 • 37 citations

Preclinical profile of stereoisomers of the anticonvulsant remacemide in mice

1991 • 19 citations

Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding.

1985 • 18 citations

Pharmacological Effects of Enantiomers of 4‐Amino‐N‐(α‐methylbenzyl)Benzamide, a Chemically Novel Anticonvulsant

1988 • 15 citations

Differential anticonvulsant effects of carbamazepine as a function of stage and type of kindling

1986 • 12 citations

New antiepileptic agents.

2004 • 12 citations

Denzimol, a new anticonvulsant drug. II. General pharmacological activities.

1983 • 11 citations

Causes of treatment failure with antiepileptic drugs vary over time

1987 • 10 citations

Recent developments in the treatment of epilepsy in children

1986 • 2 citations