Toxic Drug Reactions

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

1974 • 3,074 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Clinical Aspects of Immunology.

1969 • 1,563 citations

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

Carcinogenic Nitroso Compounds

1967 • 1,109 citations

The Specificity of Serological Reactions

1945 • 1,104 citations

Acetaminophen-induced Hepatic Necrosis

1974 • 1,021 citations

The Clinical Aspects of Immunology.

1964 • 657 citations

PLASMA-PARACETAMOL HALF-LIFE AND HEPATIC NECROSIS IN PATIENTS WITH PARACETAMOL OVERDOSAGE

1971 • 610 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

The Role of Glutathione and Glutathione S‐Transferases in Mercapturic Acid Biosynthesis

1969 • 577 citations

Acetaminophen‐induced hepatic injury: Protective role of glutathione in man and rationale for therapy

1974 • 523 citations

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

1973 • 500 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

The Specificity of Serological Reactions

1945 • 484 citations

Possible Mechanism of Liver Necrosis Caused by Aromatic Organic Compounds

1971 • 382 citations

The toxic actions of pyrrolizidine (senecio) alkaloids.

1970 • 380 citations

Vaginal Cancer after Maternal Treatment with Synthetic Estrogens

1971 • 337 citations

Biochemical Mechanisms of Drug Toxicity

1974 • 337 citations

Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.

1973 • 328 citations

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

1967 • 324 citations

LIVER NECROSIS FROM PARACETAMOL

1966 • 304 citations

Acetaminophen-Induced Hepatic Necrosis V. Correlation of Hepatic Necrosis, Covalent Binding and Glutathione Depletion in Hamsters

1974 • 303 citations

The Coronary Drug Project

1973 • 298 citations

Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen

1974 • 290 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

DRUG-INDUCED HEMOLYTIC ANEMIA

1959 • 265 citations

HEPATIC DAMAGE AND DEATH FROM OVERDOSE OF PARACETAMOL

1973 • 244 citations

SUCCESSFUL TREATMENT OF SEVERE PARACETAMOL OVERDOSAGE WITH CYSTEAMINE

1974 • 237 citations

SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).

1964 • 234 citations

Pharmacogenetics. Heredity and the Response to Drugs.

1963 • 233 citations

Clear-Cell Adenocarcinoma of the Genital Tract in Young Females

1972 • 226 citations

The role of the liver in drug metabolism

1970 • 219 citations

Role of detoxifying enzymes in bromobenzene-induced liver necrosis.

1973 • 212 citations

Recurrent Hepatitis Attributable to Halothane Sensitization in an Anesthetist

1969 • 210 citations

Handbuch der experimentellen Pharmakologie

1936 • 209 citations

THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.

1964 • 202 citations

The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.

1966 • 196 citations

Chemical Carcinogenesis.

1963 • 180 citations

Specific Carcinogenic and Teratogenic Effects of ‘Indirect’ Alkylating Methyl and Ethyl compounds, and their Dependency on Stages of Ontogenic Developments

1973 • 173 citations

Pharmacology and the future of man

1974 • 167 citations

Isoniazid Hepatitis

1973 • 162 citations

Transitional Cell Tumors of the Renal Pelvis in Analgesic Abusers

1968 • 161 citations

Impairment of Drug Metabolism in Man by Allopurinol and Nortriptyline

1970 • 161 citations

Cytotoxic Drugs in Treatment of Nonmalignant Diseases

1972 • 156 citations

Serum Transaminase Elevations and Other Hepatic Abnormalities in Patients Receiving Isoniazid

1969 • 156 citations

Die chronisch-interstitielle Nephritis

1957 • 150 citations

Bromobenzene Metabolism and Hepatic Necrosis

1971 • 141 citations

Syndrome Associated with the Abuse of Analgesics

1968 • 136 citations

Carcinoma of the renal pelvis in renal papillary necrosis.

1965 • 135 citations

Drug metabolism as a cause of drug toxicity.

1973 • 133 citations

2,3-Dihydro-2,3-dihydroxy-aflatoxin B1: An acid hydrolysis product of an RNA-aflatoxin B1 adduct formed by hamster and rat liver microsomes in vitro

1973 • 128 citations

Principles and methods for the preparation of drug protein conjugates for immunological studies.

1973 • 125 citations

Acetylation Rates and Monthly Liver Function Tests during One Year of Isoniazid Preventive Therapy

1975 • 122 citations

Nitroreductase activity of mammalian liver aldehyde oxidase.

1973 • 121 citations

Spironolactone and Testicular Cytochrome P-450: Decreased Testosterone Formation inSeveral Species and Changes in Hepatic Drug Metabolism¹

1974 • 116 citations

Phenobarbital-induced protection against toxicity of toluene and benzene in the rat

1971 • 116 citations

The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene.

1973 • 116 citations

Potentiation by Previous Drug Therapy of Hepatotoxicity following Paracetamol Overdosage

1973 • 115 citations

A Renal Lesion Caused by Abuse of Phenacetin

1959 • 114 citations

RENAL PELVIC CARCINOMA IN A SWEDISH DISTRICT WITH ABUSE OF A PHENACETIN-CONTAINING DRUG

1969 • 107 citations

The production of carcinoma of the urinary bladder in rats by feeding N-[3-(5-nitro-2-furyl)-2-thiazolyl]formamide.

1967 • 106 citations

CARCINOGENIC EFFECTS OF CYCAD MEAL AND CYCASIN, METHYLAZOXYMETHANOL GLYCOSIDE, IN RATS AND EFFECTS OF CYCASIN IN GERMFREE RATS.

1964 • 105 citations

Bildung von Chloroform aus Tetrachlorkohlenstoff in Lebermikrosomen, Lipidperoxidation und Zerst�rung von Cytochrom P-450

1972 • 103 citations

Hepatic necrosis caused by furosemide

1974 • 101 citations

Conjugations with glutathione. Distribution of glutathione S-aryltransferase in vertebrate species

1964 • 98 citations

Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide.

1969 • 96 citations

Phenacetin, through the looking glass

1967 • 86 citations

Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine

1970 • 85 citations

Inhibition of phenacetin- and acetanilide-induced methemoglobinemia in the rat by the carboxylesterase inhibitor Bis-[p-nitrophenyl] phosphate

1969 • 84 citations

Studies on the metabolic basis for the genetically determined capacities for isoniazid inactivation in man.

1965 • 81 citations

Immunochemical Mechanisms of Drug Allergy

1966 • 78 citations

Toxicity from rifampicin plus isoniazid and rifampicin plus ethambutol therapy

1971 • 77 citations

ACETOPHENETIDIN‐INDUCED METHEMOGLOBINEMIA*

1968 • 76 citations

Kidney Damage in the Golden Hamster Following Chronic Administration of Diethylstilbestrol and Sesame Oil.

1947 • 75 citations

Induction of the Unspecific Microsomal Hydroxylase in the Human Liver

2015 • 75 citations

Effect of Rifampicin and Isoniazid on Liver Function

1972 • 74 citations

Pharmacogenetics: Heredity and the Response to Drugs.

1963 • 74 citations

Reduction of niridazole by rat liver xanthine oxidase

1971 • 74 citations

Sulphadimidine Acetylation Test for Classification of Patients as Slow or Rapid Inactivators of Isoniazid

1970 • 73 citations

Toxicity of Mould-damaged Sweet Potatoes (Ipomoea batatas)

1970 • 70 citations

Analgesie nephropathy‐A review of the literature, 1967–1970

1971 • 70 citations

Drug-induced destruction of cytochrome P-450.

1973 • 67 citations

Breakdown of cytochrome P-450 heme by secobarbital and other allyl-containing barbiturates.

1973 • 67 citations

Disturbed Hepatic Function during Isoniazid Chemoprophylaxis

1973 • 66 citations

A Lung Oedema Factor from Mouldy Sweet Potatoes (Ipomoea batatas)

1971 • 64 citations

The metabolism of acetophenetidine. Isolation and characterization of S-(1-acetamido-4-hydroxyphenyl)-cysteine, a metabolite of acetophenetidine

1964 • 60 citations

Isoniazid acetylatlon rate and development of antinuclear antibodies upon isoniazid treatment

1971 • 59 citations

Cardiac Arrhythmias, Increased Intracranial Pressure, and the Autonomic Nervous System

1972 • 55 citations

Isoniazid Toxicity

1972 • 55 citations

Some new aspects of the metabolism of phenacetin in the rat

1971 • 45 citations

Hepatocarcinogenicity of griseofulvin following parenteral administration to infant mice.

1967 • 45 citations

Icterus and Febrile Reactions in Response to Isonicotinic Acid Hydrazine

1959 • 45 citations

Aerospace Problems in Pharmacology and Toxicology

1970 • 43 citations

N-Hydroxylation of p-acetophenetidide as a factor in nephrotoxicity

1973 • 41 citations

Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A.

1971 • 39 citations

Carcinogenesis in Swiss mice by isonicotinic acid hydrazide.

1966 • 39 citations

Detection of 5-(3, 4-Dihydroxy-1, 5-Cyclohexadien-1-Yl) -5-Phenylsydantoin as a Major Metabolite of 5, 5-Diphenylhydantoin (Dilantin) in the Newborn Human

1971 • 38 citations

TOXIC HEPATIC NECROSIS (HEPATITIS) DUE TO ISONIAZID: REPORT OF A CASE WITH CIRRHOSIS AND DEATH DUE TO HEMORRHAGE FROM ESOPHAGEAL VARICES

1959 • 38 citations

Cephaloridine and the Kidneys

1970 • 37 citations

ACETOPHENETIDIN‐INDUCED METHEMOGLOBINEMIA*

1968 • 37 citations

N-Hydroxyphenacetin as a precursor of 3-subst1tuted 4-hydroxyacetanilide metabolites of phenacetin

1974 • 36 citations

Patient Tolerance to Extended Irradiation in Hodgkin's Disease

1969 • 35 citations

Induction of pulmonary tumors in mice with isonicotinic acid hydrazid.

1960 • 33 citations

Massive Hepatic Necrosis after Fluroxene Anesthesia — A Case of Drug Interaction?

1972 • 32 citations

Epidemiological study of analgesic intake and its relationship to urinary tract disorders in Switzerland.

1968 • 32 citations

Über die geschwulsterzeugende Wirkung des Isonicotinsäurehydrazid (INH)

1957 • 30 citations

DRUG‐INDUCED HEMOLYTIC ANEMIAS ASSOCIATED WITH GLUCOSE‐6‐PHOSPHATE DEHYDROGENASE DEFICIENCY: A GENETICALLY HETEROGENOUS TRAIT*

1965 • 29 citations

Hepatotoxicity in Rifampin-Isoniazid Treated Patients Related to Their Rate of Isoniazid Inactivation

1972 • 28 citations

Hypersensitivity to drugs

1971 • 28 citations

THE CONSUMPTION OF ANALGESICS BY AUSTRALIAN HOSPITAL PATIENTS

1966 • 27 citations

GUANETHIDINE AND RELATED AGENTS. II. METABOLISM BY HEPATIC MICROSOMES AND ITS INHIBITION BY DRUGS

1970 • 26 citations

On the Commonness, Causes and Detrimental Effects of the Use of Analgesics by Factory Workers and Hospital Patients

1962 • 24 citations

Effect of steroids on drug metabolism in male and female rats.

1973 • 24 citations

Drug Responses in Man.

1968 • 23 citations

�ber die harnausscheidung von furosemid bei gesunden und kranken mit lebercirrhose

1970 • 21 citations

Liver damage and isoniazid allergy.

1969 • 21 citations

Massive Lethal Hepatic Necrosis in Rats Anesthetized with Fluroxene, after Microsomal Enzyme Induction

1973 • 20 citations

Metabolische umwandlung von phenacetin und N-acetyl-p-aminophenol nach vorbehandlung mit phenobarbital

1967 • 19 citations

The toxicity of two synthetic 3-substituted furan carbamates

1973 • 19 citations

Failure to Demonstrate Transformation of Lymphocytes of Patients with Isoniazid-Associated Hepatitis

1972 • 18 citations

Experience with Lymphocyte Transformation Tests in Evaluating Allergy to Aminosalicylic Acid, Isoniazid and Streptomycin

1972 • 18 citations

ANALGESIC ABUSE AND TUMOURS OF RENAL PELVIS

1970 • 17 citations

Mechanisms of pyrrolizidine alkaloid toxicity

1972 • 17 citations

THE EFFECT OF SOLDACTONA® (CANRENOATE-POTASSIUM) ON PLASMA TESTOSTERONE AND ANDROSTENEDIONE AND URINARY 17-KETOSTEROIDS AND 17-HYDROXYCORTICOSTEROIDS

1972 • 14 citations

Reduction of Heterocyclic Nitro Compounds in the Rat Liver

1971 • 14 citations

Modification by para-aminosalicylic acid and sulfamethazine of the isoniazid inactivation in man.

1969 • 13 citations

Rifampin plus Isoniazid in Initial Therapy of Pulmonary Tuberculosis and Rifampin and Ethambutol in Retreatment Cases

1972 • 12 citations

Drug Induced Diseases, vol 3.

1969 • 12 citations

The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.

1972 • 11 citations

Metabolism of N,2-dimethyl-2-phenylsuccinimide (methsuximide) by the epoxide-diol pathway in rat, guinea pig and human.

1973 • 9 citations

Experiences of intensive coronary care in a regional hospital

1971 • 8 citations

Hypersensitivity to Drugs.

1973 • 8 citations

Drugs with Lactone Groups as Potential Carcinogens

1967 • 4 citations

Toxicity to Para-aminosalicylic Acid and Isoniazid

1960 • 4 citations

[Isonicotinic acid hydrazide (INH) as a "carcinogenic" factor in mice. I].

1961 • 3 citations

Analgesic Abuse and Tumours of the Renal Pelvis

1969 • 3 citations

The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450.

1973 • 3 citations

RECURRENT HEPATITIS ATTRIBUTABLE TO HALOTHANE SENSITIZATION IN AN ANESTHETIST

1970 • 2 citations

[Isonicotinic acid hydrazide (INH) as a "carcinogenic" wgent in mice. II].

1962 • 2 citations

Isoniazid: How Much a Carcinogen ?

1966 • 1 citations

Deleted Work

1955 • 0 citations